Regulation of lipid metabolism by obeticholic acid in hyperlipidemic hamsters

Effects of obeticholic acid on lipoprotein metabolism in healthy volunteers

(2016) R. Pencek et al.   DIABETES OBESITY & METABOLISM

Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease

(2016) Paolo Zanoni et al.   SCIENCE

MAFG Is a Transcriptional Repressor of Bile Acid Synthesis and Metabolism

(2015) Thomas Q. de Aguiar Vallim et al.   Cell Metabolism

Future therapeutic targets for the treatment and prevention of cholesterol gallstones

(2015) Ibrahim Guillermo Castro-Torres et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Efficacy of Obeticholic Acid in Patients With Primary Biliary Cirrhosis and Inadequate Response to Ursodeoxycholic Acid

(2015) Gideon M. Hirschfield et al.   GASTROENTEROLOGY

Discovery of 6-(4-{[5-Cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl]methoxy}piperidin-1-yl)-1-methyl-1H-indole-3-carboxylic Acid: A Novel FXR Agonist for the Treatment of Dyslipidemia

(2015) Michael J. Genin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial

(2015) Brent A Neuschwander-Tetri et al.   LANCET

Dysfunctional HDL and atherosclerotic cardiovascular disease

(2015) Robert S. Rosenson et al.   Nature Reviews Cardiology

The Effects of Diet on Occlusive Coronary Artery Atherosclerosis and Myocardial Infarction in Scavenger Receptor Class B, Type 1/Low-Density Lipoprotein Receptor Double Knockout Mice

(2014) Mark Fuller et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

CETP inhibitors downregulate hepatic LDL receptor and PCSK9 expression in vitro and in vivo through a SREBP2 dependent mechanism

(2014) Bin Dong et al.   ATHEROSCLEROSIS

Cholesterol efflux is LXRα isoform-dependent in human macrophages

(2014) A Zhi Sha Ma et al.   BMC Cardiovascular Disorders

Inhibition ofPCSK9Transcription by Berberine Involves Down-regulation of Hepatic HNF1α Protein Expression through the Ubiquitin-Proteasome Degradation Pathway

(2014) Bin Dong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Scavenger Receptor class B type I (SR-BI): A versatile receptor with multiple functions and actions

(2014) Wen-Jun Shen et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Genome-Wide Binding and Transcriptome Analysis of Human Farnesoid X Receptor in Primary Human Hepatocytes

(2014) Le Zhan et al.   PLoS One

New developments in selective cholesteryl ester uptake

(2013) Jason M. Meyer et al.   CURRENT OPINION IN LIPIDOLOGY

Efficacy and Safety of the Farnesoid X Receptor Agonist Obeticholic Acid in Patients With Type 2 Diabetes and Nonalcoholic Fatty Liver Disease

(2013) Sunder Mudaliar et al.   GASTROENTEROLOGY

High-fructose diet downregulates long-chain acyl-CoA synthetase 3 expression in liver of hamsters via impairing LXR/RXR signaling pathway

(2013) Bin Dong et al.   JOURNAL OF LIPID RESEARCH

Differential regulation of bile acid and cholesterol metabolism by the farnesoid X receptor inLdlr−/−mice versus hamsters

(2013) Christophe Gardès et al.   JOURNAL OF LIPID RESEARCH

Farnesoid X receptor targeting to treat nonalcoholic steatohepatitis

(2012) Luciano Adorini et al.   DRUG DISCOVERY TODAY

Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR

(2012) Anna C. Calkin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Farnesoid X Receptor Induces Murine Scavenger Receptor Class B Type I via Intron Binding

(2012) Guodong Li et al.   PLoS One

Chenodeoxycholic acid stabilization of LDL receptor mRNA depends on 3′-untranslated region and AU-rich element-binding protein

(2011) Takuya Yashiro et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Novel mutations in scavenger receptor BI associated with high HDL cholesterol in humans

(2011) LR Brunham et al.   CLINICAL GENETICS

Janus kinase activation by cytokine oncostatin M decreases PCSK9 expression in liver cells

(2011) Aiqin Cao et al.   JOURNAL OF LIPID RESEARCH

Studies in mice, hamsters, and rats demonstrate that repression of hepatic apoA-I expression by taurocholic acid in mice is not mediated by the farnesoid-X-receptor

(2011) Christophe Gardès et al.   JOURNAL OF LIPID RESEARCH

Genetic Variant of the Scavenger Receptor BI in Humans

(2011) Menno Vergeer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Upregulation of scavenger receptor class B type I expression by activation of FXR in hepatocyte

(2010) Fan Chao et al.   ATHEROSCLEROSIS

Evaluation of anti-atherosclerotic activities of PPAR-α, PPAR-γ, and LXR agonists in hyperlipidemic atherosclerosis-susceptible F1B hamsters

(2010) Rai Ajit K. Srivastava   ATHEROSCLEROSIS

Biliary Sterol Secretion Is Required for Functional In Vivo Reverse Cholesterol Transport in Mice

(2010) Niels Nijstad et al.   GASTROENTEROLOGY

Anti-hyperlipidemic and insulin sensitizing activities of fenofibrate reduces aortic lipid deposition in hyperlipidemic Golden Syrian hamster

(2010) Rai Ajit K. Srivastava et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

A synthetic farnesoid X receptor (FXR) agonist promotes cholesterol lowering in models of dyslipidemia

(2009) Mark J. Evans et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Genome-wide tissue-specific farnesoid X receptor binding in mouse liver and intestine

(2009) Ann M. Thomas et al.   HEPATOLOGY

Scavenger receptor class B type I mediates biliary cholesterol secretion independent of ATP-binding cassette transporter g5/g8 in mice

(2009) Harmen Wiersma et al.   HEPATOLOGY

Hepatocyte Nuclear Factor 1α Plays a Critical Role inPCSK9Gene Transcription and Regulation by the Natural Hypocholesterolemic Compound Berberine

(2009) Hai Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Novel Pathways That Control Farnesoid X Receptor-mediated Hypocholesterolemia

(2009) Yanqiao Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FXR activation reverses insulin resistance and lipid abnormalities and protects against liver steatosis in Zucker (fa/fa) obese rats

(2009) Sabrina Cipriani et al.   JOURNAL OF LIPID RESEARCH

Activation of the farnesoid X receptor represses PCSK9 expression in human hepatocytes

(2008) Cédric Langhi et al.   FEBS LETTERS