The interplay between extracellular matrix remodelling and kinase signalling in cancer progression and metastasis

A Phase II, Randomized, Double‐Blind, Placebo‐Controlled Study of Simtuzumab in Combination with FOLFIRI for the Second‐Line Treatment of MetastaticKRASMutant Colorectal Adenocarcinoma

(2017) J. Randolph Hecht et al.   ONCOLOGIST

A Phase II Randomized, Double‐Blind, Placebo‐Controlled Study of Simtuzumab or Placebo in Combination with Gemcitabine for the First‐Line Treatment of Pancreatic Adenocarcinoma

(2017) Al B. Benson et al.   ONCOLOGIST

Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface

(2017) HaoRan Tang et al.   Nature Communications

Mesenchymal Stem Cell-Induced DDR2 Mediates Stromal-Breast Cancer Interactions and Metastasis Growth

(2017) Maria E. Gonzalez et al.   Cell Reports

Integrins as Therapeutic Targets: Successes and Cancers

(2017) Sabine Raab-Westphal et al.   Cancers

Targeted inhibition of Focal Adhesion Kinase Attenuates Cardiac Fibrosis and Preserves Heart Function in Adverse Cardiac Remodeling

(2017) Jie Zhang et al.   Scientific Reports

Economic sustainability of anti-PD-1 agents nivolumab and pembrolizumab in cancer patients: Recent insights and future challenges

(2016) Francesca Tartari et al.   CANCER TREATMENT REVIEWS

ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth

(2016) Nicola Rath et al.   EMBO Molecular Medicine

Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression

(2016) Hanane Laklai et al.   NATURE MEDICINE

Integrin-based therapeutics: biological basis, clinical use and new drugs

(2016) Klaus Ley et al.   NATURE REVIEWS DRUG DISCOVERY

Periostin expression in cancer-associated fibroblasts of invasive ductal breast carcinoma

(2016) Katarzyna Ratajczak-Wielgomas et al.   ONCOLOGY REPORTS

The Elastin Receptor Complex: A Unique Matricellular Receptor with High Anti-tumoral Potential

(2016) Amandine Scandolera et al.   Frontiers in Pharmacology

TGFβ3-mediated induction of Periostin facilitates head and neck cancer growth and is associated with metastasis

(2016) Xing Qin et al.   Scientific Reports

The potential of Src inhibitors

(2015) Daniel Elias et al.   Aging-US

Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy

(2015) Bryan W Miller et al.   EMBO Molecular Medicine

Proteomic database mining opens up avenues utilizing extracellular protein phosphorylation for novel therapeutic applications

(2015) Garif Yalak et al.   Journal of Translational Medicine

The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase

(2015) Thomas R. Cox et al.   NATURE

Targeting the TGFβ pathway for cancer therapy

(2015) Cindy Neuzillet et al.   PHARMACOLOGY & THERAPEUTICS

Tumour-derived SPARC drives vascular permeability and extravasation through endothelial VCAM1 signalling to promote metastasis

(2015) Mélanie Tichet et al.   Nature Communications

A secretory kinase complex regulates extracellular protein phosphorylation

(2015) Jixin Cui et al.   eLife

Targeting ECM Disrupts Cancer Progression

(2015) Freja A. Venning et al.   Frontiers in Oncology

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

(2014) Berna C. Özdemir et al.   CANCER CELL

Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma

(2014) Andrew D. Rhim et al.   CANCER CELL

A Secreted Tyrosine Kinase Acts in the Extracellular Environment

(2014) Mattia R. Bordoli et al.   CELL

Targeting FAK in human cancer: from finding to first clinical trials

(2014) Vita Golubovskaya   Frontiers in Bioscience-Landmark

Discoidin Domain Receptor 2 Signaling Networks and Therapy in Lung Cancer

(2014) Leo S. Payne et al.   Journal of Thoracic Oncology

FAK Inhibition Disrupts a  5 Integrin Signaling Axis Controlling Anchorage-Independent Ovarian Carcinoma Growth

(2014) I. Tancioni et al.   MOLECULAR CANCER THERAPEUTICS

Remodelling the extracellular matrix in development and disease

(2014) Caroline Bonnans et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Periostin suppression induces decorin secretion leading to reduced breast cancer cell motility and invasion

(2014) Toshiyuki Ishiba et al.   Scientific Reports

LOX-Mediated Collagen Crosslinking Is Responsible for Fibrosis-Enhanced Metastasis

(2013) T. R. Cox et al.   CANCER RESEARCH

Tumor-Secreted LOXL2 Activates Fibroblasts through FAK Signaling

(2013) H. E. Barker et al.   MOLECULAR CANCER RESEARCH

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

Lysyl Oxidase Plays a Critical Role in Endothelial Cell Stimulation to Drive Tumor Angiogenesis

(2012) A.-M. Baker et al.   CANCER RESEARCH

Elastin-derived peptides increase invasive capacities of lung cancer cells by post-transcriptional regulation of MMP-2 and uPA

(2012) Simon Toupance et al.   CLINICAL & EXPERIMENTAL METASTASIS

The extracellular matrix: A dynamic niche in cancer progression

(2012) Pengfei Lu et al.   JOURNAL OF CELL BIOLOGY

Lysyl oxidase enzymatic function increases stiffness to drive colorectal cancer progression through FAK

(2012) A-M Baker et al.   ONCOGENE

Secreted Kinase Phosphorylates Extracellular Proteins That Regulate Biomineralization

(2012) V. S. Tagliabracci et al.   SCIENCE

Knockdown of aberrantly expressed nuclear localized decorin attenuates tumour angiogenesis related mediators in oral cancer progression model in vitro

(2012) Nyla Dil et al.   Head and Neck Optical Diagnostics Society

Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth

(2011) Michael S. Samuel et al.   CANCER CELL

Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer

(2011) T. R. Cox et al.   Disease Models & Mechanisms

The Role of Lysyl Oxidase in SRC-Dependent Proliferation and Metastasis of Colorectal Cancer

(2011) Ann-Marie Baker et al.   JNCI-Journal of the National Cancer Institute

Interactions between cancer stem cells and their niche govern metastatic colonization

(2011) Ilaria Malanchi et al.   NATURE

Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs

(2011) Thordur Oskarsson et al.   NATURE MEDICINE

Extracellular Matrix Degradation and Remodeling in Development and Disease

(2011) P. Lu et al.   Cold Spring Harbor Perspectives in Biology

Elastin-derived peptides enhance melanoma growth in vivo by upregulating the activation of Mcol-A (MMP-1) collagenase

(2010) J Devy et al.   BRITISH JOURNAL OF CANCER

Hyaluronan-CD44 Interaction Promotes c-Src-mediated Twist Signaling, MicroRNA-10b Expression, and RhoA/RhoC Up-regulation, Leading to Rho-kinase-associated Cytoskeleton Activation and Breast Tumor Cell Invasion

(2010) Lilly Y. W. Bourguignon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The extracellular matrix at a glance

(2010) C. Frantz et al.   JOURNAL OF CELL SCIENCE

The biological role and regulation of versican levels in cancer

(2009) Carmela Ricciardelli et al.   CANCER AND METASTASIS REVIEWS

Hypoxia-Induced Lysyl Oxidase Is a Critical Mediator of Bone Marrow Cell Recruitment to Form the Premetastatic Niche

(2009) Janine T. Erler et al.   CANCER CELL

Proteinases involved in matrix turnover during cartilage and bone breakdown

(2009) Tim E. Cawston et al.   CELL AND TISSUE RESEARCH

Osteoclast migration on phosphorylated osteopontin is regulated by endogenous tartrate-resistant acid phosphatase

(2009) Barbro Ek-Rylander et al.   EXPERIMENTAL CELL RESEARCH

The biomechanical integrin

(2009) Erin L. Baker et al.   JOURNAL OF BIOMECHANICS

The Extracellular Matrix: Not Just Pretty Fibrils

(2009) R. O. Hynes   SCIENCE

Periostin deposition in the stroma of invasive and intraductal neoplasms of the pancreas

(2008) Noriyoshi Fukushima et al.   MODERN PATHOLOGY

Expression of periostin in human breast cancer

(2007) F Puglisi et al.   JOURNAL OF CLINICAL PATHOLOGY