Ras activation by SOS: Allosteric regulation by altered fluctuation dynamics

Encoding and Decoding Cellular Information through Signaling Dynamics

(2013) Jeremy E. Purvis et al.   CELL

Higher-Order Assemblies in a New Paradigm of Signal Transduction

(2013) Hao Wu   CELL

Regulation of Small GTPases by GEFs, GAPs, and GDIs

(2013) Jacqueline Cherfils et al.   PHYSIOLOGICAL REVIEWS

Direct single molecule measurement of TCR triggering by agonist pMHC in living primary T cells

(2013) Geoff P O'Donoghue et al.   eLife

Allostery and the Monod-Wyman-Changeux Model After 50 Years

(2012) Jean-Pierre Changeux   Annual Review of Biophysics

N-Ras Forms Dimers at POPC Membranes

(2012) Jörn Güldenhaupt et al.   BIOPHYSICAL JOURNAL

Monitoring Lipid Anchor Organization in Cell Membranes by PIE-FCCS

(2012) Sara B. Triffo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein activity regulation by conformational entropy

(2012) Shiou-Ru Tzeng et al.   NATURE

Signaling from the Living Plasma Membrane

(2011) Hernán E. Grecco et al.   CELL

Signaling clusters in the cell membrane

(2011) Niña C Hartman et al.   CURRENT OPINION IN CELL BIOLOGY

Using patterned supported lipid membranes to investigate the role of receptor organization in intercellular signaling

(2011) Pradeep M Nair et al.   Nature Protocols

T-cell triggering thresholds are modulated by the number of antigen within individual T-cell receptor clusters

(2011) B. N. Manz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signalling ballet in space and time

(2010) Boris N. Kholodenko et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular mechanisms in signal transduction at the membrane

(2010) Jay T Groves et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Role of the histone domain in the autoinhibition and activation of the Ras activator Son of Sevenless

(2010) Jodi Gureasko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Allosteric gating of Son of sevenless activity by the histone domain

(2010) Kamlesh K. Yadav et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induced fit, conformational selection and independent dynamic segments: an extended view of binding events

(2010) Peter Csermely et al.   TRENDS IN BIOCHEMICAL SCIENCES

Rasosomes spread Ras signals from plasma membrane ‘hotspots’

(2009) Merav Kofer-Geles et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Digital Signaling and Hysteresis Characterize Ras Activation in Lymphoid Cells

(2009) Jayajit Das et al.   CELL

Bayesian Detection of Intensity Changes in Single Molecule and Molecular Dynamics Trajectories

(2009) Daniel L. Ensign et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Dynamic activation of an allosteric regulatory protein

(2009) Shiou-Ru Tzeng et al.   NATURE

The role of dynamic conformational ensembles in biomolecular recognition

(2009) David D Boehr et al.   Nature Chemical Biology

Sending Signals Dynamically

(2009) R. G. Smock et al.   SCIENCE

Cell Signaling in Space and Time: Where Proteins Come Together and When They're Apart

(2009) J. D. Scott et al.   SCIENCE

Differences in Flexibility Underlie Functional Differences in the Ras Activators Son of Sevenless and Ras Guanine Nucleotide Releasing Factor 1

(2009) Tanya S. Freedman et al.   STRUCTURE

The Origin of Allosteric Functional Modulation: Multiple Pre-existing Pathways

(2009) Antonio del Sol et al.   STRUCTURE

Fluorescence Imaging of Membrane Dynamics

(2008) Jay T. Groves et al.   Annual Review of Biomedical Engineering

Membrane-dependent signal integration by the Ras activator Son of sevenless

(2008) Jodi Gureasko et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Internal dynamics control activation and activity of the autoinhibited Vav DH domain

(2008) Pilong Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Stochastic Single-Molecule Event Triggers Phenotype Switching of a Bacterial Cell

(2008) P. J. Choi et al.   SCIENCE

Using plasma membrane nanoclusters to build better signaling circuits

(2008) Angus S. Harding et al.   TRENDS IN CELL BIOLOGY