The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction

Defective Leukocyte Adhesion and Chemotaxis Contributes to Combined Immunodeficiency in Humans with Autosomal Recessive MST1 Deficiency

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The first trial of CIM331, a humanized antihuman interleukin-31 receptor A antibody, in healthy volunteers and patients with atopic dermatitis to evaluate safety, tolerability and pharmacokinetics of a single dose in a randomized, double-blind, placebo-co

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STK4 (MST1) deficiency in two siblings with autoimmune cytopenias: A novel mutation

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The extended clinical phenotype of 64 patients with dedicator of cytokinesis 8 deficiency

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Coincidental loss of DOCK8 function in NLRP10-deficient and C3H/HeJ mice results in defective dendritic cell migration

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Regulation of mammalian Ste20 (Mst) kinases

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Antipruritic mechanisms of topical E6005, a phosphodiesterase 4 inhibitor: Inhibition of responses to proteinase-activated receptor 2 stimulation mediated by increase in intracellular cyclic AMP

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DOCK8 regulates lymphocyte shape integrity for skin antiviral immunity

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Therapeutic Effects and Immunomodulation of Suanbo Mineral Water Therapy in a Murine Model of Atopic Dermatitis

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DOCK8 is critical for the survival and function of NKT cells

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Enhanceosomes as integrators of hypoxia inducible factor (HIF) and other transcription factors in the hypoxic transcriptional response

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Genetic, Clinical, and Laboratory Markers for DOCK8 Immunodeficiency Syndrome

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Clinical Manifestations of Hyper IgE Syndromes

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T Cell-Positive Selection Uses Self-Ligand Binding Strength to Optimize Repertoire Recognition of Foreign Antigens

(2013) Judith N. Mandl et al.   IMMUNITY

Defective actin accumulation impairs human natural killer cell function in patients with dedicator of cytokinesis 8 deficiency

(2013) Melissa C. Mizesko et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A sensory neuron–expressed IL-31 receptor mediates T helper cell–dependent itch: Involvement of TRPV1 and TRPA1

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Transcription Factors Sp1 and Hif2α Mediate Induction of the Copper-transporting ATPase ( Atp7a ) Gene in Intestinal Epithelial Cells during Hypoxia

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Allosteric inhibition of hypoxia inducible factor-2 with small molecules

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Acute eosinophilic pneumonia occurring in a dedicator of cytokinesis 8 (DOCK8) deficient patient

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DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses

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Hypoxia-Inducible Factors in Physiology and Medicine

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DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation

(2012) Haifa H Jabara et al.   NATURE IMMUNOLOGY

HIF2α-Sp1 interaction mediates a deacetylation-dependent FVII- gene activation under hypoxic conditions in ovarian cancer cells

(2012) Shiro Koizume et al.   NUCLEIC ACIDS RESEARCH

An update on the hyper-IgE syndromes

(2012) Patrick FK Yong et al.   ARTHRITIS RESEARCH & THERAPY

MST1 mutations in autosomal recessive primary immunodeficiency characterized by defective naive T-cell survival

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Signaling by IL-31 and functional consequences

(2011) Christian Cornelissen et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

DOCK8 is essential for T-cell survival and the maintenance of CD8+ T-cell memory

(2011) Teresa Lambe et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice

(2011) Katrina L. Randall et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Genome-wide Profiling of Interleukin-4 and STAT6 Transcription Factor Regulation of Human Th2 Cell Programming

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Transcriptional regulation of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis development

(2010) Taku Saito et al.   NATURE MEDICINE

Hypoxia-inducible factor-2α is a catabolic regulator of osteoarthritic cartilage destruction

(2010) Siyoung Yang et al.   NATURE MEDICINE

FM19G11, a New Hypoxia-inducible Factor (HIF) Modulator, Affects Stem Cell Differentiation Status

(2009) Victoria Moreno-Manzano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Guidelines for management of atopic dermatitis

(2009) Hidehisa SAEKI et al.   JOURNAL OF DERMATOLOGY

Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production

(2009) Katrina L Randall et al.   NATURE IMMUNOLOGY

Combined Immunodeficiency Associated withDOCK8Mutations

(2009) Qian Zhang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Correlation of IL-31 serum levels with severity of atopic dermatitis

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Atopic Dermatitis

(2008) Thomas Bieber   NEW ENGLAND JOURNAL OF MEDICINE