Inactivation of class II PI3K-C2α induces leptin resistance, age-dependent insulin resistance and obesity in male mice
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Title
Inactivation of class II PI3K-C2α induces leptin resistance, age-dependent insulin resistance and obesity in male mice
Authors
Keywords
Food intake, Glucose homeostasis, Insulin, Insulin resistance, Knock-in leptin, Leptin resistance, Mouse gene targeting, Obesity, PI3K
Journal
DIABETOLOGIA
Volume 59, Issue 7, Pages 1503-1512
Publisher
Springer Nature
Online
2016-04-30
DOI
10.1007/s00125-016-3963-y
References
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Note: Only part of the references are listed.- Essential role of class II PI3K-C2 in platelet membrane morphology
- (2015) C. Valet et al. BLOOD
- PI3K-C2α: One enzyme for two products coupling vesicle trafficking and signal transduction
- (2015) Carlo C. Campa et al. FEBS LETTERS
- Ceramide limits phosphatidylinositol-3-kinase C2β-controlled cell motility in ovarian cancer: potential of ceramide as a metastasis-suppressor lipid
- (2015) K Kitatani et al. ONCOGENE
- PI3K-C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling
- (2015) Laura Braccini et al. Nature Communications
- PI3K-C2α Knockdown Results in Rerouting of Insulin Signaling and Pancreatic Beta Cell Proliferation
- (2015) Barbara Leibiger et al. Cell Reports
- Inactivation of the Class II PI3K-C2β Potentiates Insulin Signaling and Sensitivity
- (2015) Samira Alliouachene et al. Cell Reports
- PI3K Class II α Controls Spatially Restricted Endosomal PtdIns3P and Rab11 Activation to Promote Primary Cilium Function
- (2014) Irene Franco et al. DEVELOPMENTAL CELL
- Classes of phosphoinositide 3-kinases at a glance
- (2014) S. Jean et al. JOURNAL OF CELL SCIENCE
- Leptin-promoted cilia assembly is critical for normal energy balance
- (2014) Yu Mi Han et al. JOURNAL OF CLINICAL INVESTIGATION
- Involvement of Class II Phosphoinositide 3-Kinase α-Isoform in Antigen-Induced Degranulation in RBL-2H3 Cells
- (2014) Kiyomi Nigorikawa et al. PLoS One
- Bardet–Biedl syndrome proteins control the cilia length through regulation of actin polymerization
- (2013) Victor Hernandez-Hernandez et al. HUMAN MOLECULAR GENETICS
- Reduced Ciliary Polycystin-2 in Induced Pluripotent Stem Cells from Polycystic Kidney Disease Patients with PKD1 Mutations
- (2013) B. S. Freedman et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate
- (2013) York Posor et al. NATURE
- Leptin resistance is a secondary consequence of the obesity in ciliopathy mutant mice
- (2013) N. F. Berbari et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Regulation and cellular functions of class II phosphoinositide 3-kinases
- (2012) Marco Falasca et al. BIOCHEMICAL JOURNAL
- Endothelial PI3K-C2α, a class II PI3K, has an essential role in angiogenesis and vascular barrier function
- (2012) Kazuaki Yoshioka et al. NATURE MEDICINE
- Patients with Bardet-Biedl Syndrome Have Hyperleptinemia Suggestive of Leptin Resistance
- (2011) Penelope P. Feuillan et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Specific Roles of the p110α Isoform of Phosphatidylinsositol 3-Kinase in Hepatic Insulin Signaling and Metabolic Regulation
- (2010) Victoria Rotter Sopasakis et al. Cell Metabolism
- Insulin-feedback via PI3K-C2α activated PKBα/Akt1 is required for glucose-stimulated insulin secretion
- (2010) Barbara Leibiger et al. FASEB JOURNAL
- Class II Phosphoinositide 3-Kinase Regulates Exocytosis of Insulin Granules in Pancreatic β Cells
- (2010) Veronica Dominguez et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Requirement for Class II Phosphoinositide 3-Kinase C2 in Maintenance of Glomerular Structure and Function
- (2010) D. P. Harris et al. MOLECULAR AND CELLULAR BIOLOGY
- The emerging mechanisms of isoform-specific PI3K signalling
- (2010) Bart Vanhaesebroeck et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Recent advances in understanding leptin signaling and leptin resistance
- (2009) David L. Morris et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Dominant Role of the p110β Isoform of PI3K over p110α in Energy Homeostasis Regulation by POMC and AgRP Neurons
- (2009) Hind Al-Qassab et al. Cell Metabolism
- Requirement of Bardet-Biedl syndrome proteins for leptin receptor signaling
- (2009) Seongjin Seo et al. HUMAN MOLECULAR GENETICS
- Leptin resistance contributes to obesity and hypertension in mouse models of Bardet-Biedl syndrome
- (2008) Kamal Rahmouni et al. JOURNAL OF CLINICAL INVESTIGATION
- Angiogenesis selectively requires the p110α isoform of PI3K to control endothelial cell migration
- (2008) Mariona Graupera et al. NATURE
- The p110 isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110
- (2008) J. Guillermet-Guibert et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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