Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase

Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis

(2017) Ann L. Walker et al.   JOURNAL OF MEDICINAL CHEMISTRY

Kynurenine-3-monooxygenase: a review of structure, mechanism, and inhibitors

(2016) Jason R. Smith et al.   DRUG DISCOVERY TODAY

The novel KMO inhibitor CHDI-340246 leads to a restoration of electrophysiological alterations in mouse models of Huntington's disease

(2016) Vahri Beaumont et al.   EXPERIMENTAL NEUROLOGY

Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis

(2016) Damian J Mole et al.   NATURE MEDICINE

Current Evidence for a Role of the Kynurenine Pathway of Tryptophan Metabolism in Multiple Sclerosis

(2016) Michael D. Lovelace et al.   Frontiers in Immunology

Increased levels of 3-hydroxykynurenine parallel disease severity in human acute pancreatitis

(2016) Christos Skouras et al.   Scientific Reports

The drug–target residence time model: a 10-year retrospective

(2015) Robert A. Copeland   NATURE REVIEWS DRUG DISCOVERY

Crystallographic Evidence of Drastic Conformational Changes in the Active Site of a Flavin-Dependent N-Hydroxylase

(2014) Jeremy W. Setser et al.   BIOCHEMISTRY

How good are my data and what is the resolution?

(2013) Philip R. Evans et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Activation of NAD(P)H Oxidase by Tryptophan-Derived 3-Hydroxykynurenine Accelerates Endothelial Apoptosis and Dysfunction In Vivo

(2013) Qiongxin Wang et al.   CIRCULATION RESEARCH

Crystal Structure of 3-Hydroxybenzoate 6-Hydroxylase Uncovers Lipid-assisted Flavoprotein Strategy for Regioselective Aromatic Hydroxylation

(2013) Stefania Montersino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis of kynurenine 3-monooxygenase inhibition

(2013) Marta Amaral et al.   NATURE

Structural Insight into the Mechanism of Oxygen Activation and Substrate Selectivity of Flavin-Dependent N-Hydroxylating Monooxygenases

(2012) Stefano Franceschini et al.   BIOCHEMISTRY

Form Follows Function: Structural and Catalytic Variation in the Class A Flavoprotein Monooxygenases

(2012) Karen Crozier-Reabe et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Kynurenines in the CNS: recent advances and new questions

(2012) László Vécsei et al.   NATURE REVIEWS DRUG DISCOVERY

Data processing and analysis with theautoPROCtoolbox

(2011) Clemens Vonrhein et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

iMOSFLM: a new graphical interface for diffraction-image processing withMOSFLM

(2011) T. Geoff G. Battye et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

REFMAC5 for the refinement of macromolecular crystal structures

(2011) Garib N. Murshudov et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Kynurenine 3-Monooxygenase Inhibition in Blood Ameliorates Neurodegeneration

(2011) Daniel Zwilling et al.   CELL

Two Structures of anN-Hydroxylating Flavoprotein Monooxygenase

(2011) Jose Olucha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Are pyridazines privileged structures?

(2011) Camille G. Wermuth   MedChemComm

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Incidence of individual organ dysfunction in fatal acute pancreatitis: analysis of 1024 death records

(2010) Damian J. Mole et al.   HPB

Control of catalysis in flavin-dependent monooxygenases

(2009) Bruce A. Palfey et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Structural Insights into Regioselectivity in the Enzymatic Chlorination of Tryptophan

(2009) Xiaofeng Zhu et al.   JOURNAL OF MOLECULAR BIOLOGY

FitSpace Explorer: An algorithm to evaluate multidimensional parameter space in fitting kinetic data

(2008) Kenneth A. Johnson et al.   ANALYTICAL BIOCHEMISTRY

Global Kinetic Explorer: A new computer program for dynamic simulation and fitting of kinetic data

(2008) Kenneth A. Johnson et al.   ANALYTICAL BIOCHEMISTRY

Kynurenine 3-Monooxygenase fromPseudomonas fluorescens: Substrate-like Inhibitors both Stimulate Flavin Reduction and Stabilize the Flavin−Peroxo Intermediate yet Result in the Production of Hydrogen Peroxide

(2008) Karen R. Crozier-Reabe et al.   BIOCHEMISTRY

Residence Time of Receptor−Ligand Complexes and Its Effect on Biological Function

(2008) Peter J. Tummino et al.   BIOCHEMISTRY