Journal
ARCHIVES OF PHARMACAL RESEARCH
Volume 39, Issue 8, Pages 1062-1074Publisher
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/s12272-016-0812-y
Keywords
FXR; Energy metabolism; Autophagy; Mitochondria; Cell viability
Categories
Funding
- Korea Institute of Oriental Medicine [K16820]
- Bio and Medical Technology Development Program of the NRF - Korean government, MSIP [2015M3A9B6074045]
Ask authors/readers for more resources
Maintenance of energy homeostasis is crucial for survival of organism. There exists a close link between energy metabolism and cell survival, which are coordinately regulated by common signaling pathways. Farnesoid X receptor (FXR) serves as a ligand-mediated transcription factor to regulate diverse genes involved in bile acid, lipid, and glucose metabolism, controlling cellular and systemic energy metabolism. Another important aspect on FXR biology is related to its beneficial effect on cell survival. FXR exerts antioxidative and cytoprotective effect, which is closely associated with the ability of FXR to regulate mitochondrial function. To maintain complex biological processes under homeostasis, FXR activity needs to be dynamically and tightly controlled by different signaling pathways and modifications. In this review, we discuss the role of FXR in the regulation of energy metabolism and cell survival, with the goal of understanding molecular basis for FXR regulation in physiological and pathological conditions. This information may be of assistance in understanding recent advancements of FXR research and strategies for the prevention and treatment of metabolic disorders.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available