Cilia and Obesity

Modulation of leptin resistance by food compounds

(2016) Gerard Aragonès et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Primary Cilia and Mammalian Hedgehog Signaling

(2016) Fiona Bangs et al.   Cold Spring Harbor Perspectives in Biology

Ciliopathies

(2016) Daniela A. Braun et al.   Cold Spring Harbor Perspectives in Biology

The BBSome Controls Energy Homeostasis by Mediating the Transport of the Leptin Receptor to the Plasma Membrane

(2016) Deng-Fu Guo et al.   PLoS Genetics

Proteomics of Primary Cilia by Proximity Labeling

(2015) David U. Mick et al.   DEVELOPMENTAL CELL

Pro-Opiomelanocortin (POMC) Neurones, POMC-Derived Peptides, Melanocortin Receptors and Obesity: How Understanding of this System has Changed Over the Last Decade

(2015) K. G. Mountjoy   JOURNAL OF NEUROENDOCRINOLOGY

G-protein-independent coupling of MC4R to Kir7.1 in hypothalamic neurons

(2015) Masoud Ghamari-Langroudi et al.   NATURE

A neural basis for melanocortin-4 receptor–regulated appetite

(2015) Alastair S Garfield et al.   NATURE NEUROSCIENCE

Adipogenic Differentiation of hMSCs is Mediated by Recruitment of IGF-1r Onto the Primary Cilium Associated With Cilia Elongation

(2015) Melis T. Dalbay et al.   STEM CELLS

Hypomorphism for RPGRIP1L, a Ciliary Gene Vicinal to the FTO Locus, Causes Increased Adiposity in Mice

(2014) George Stratigopoulos et al.   Cell Metabolism

The Intraflagellar Transport Protein IFT27 Promotes BBSome Exit from Cilia through the GTPase ARL6/BBS3

(2014) Gerald M. Liew et al.   DEVELOPMENTAL CELL

Impaired kisspeptin signaling decreases metabolism and promotes glucose intolerance and obesity

(2014) Kristen P. Tolson et al.   JOURNAL OF CLINICAL INVESTIGATION

Obesity-associated variants within FTO form long-range functional connections with IRX3

(2014) Scott Smemo et al.   NATURE

Structural basis for membrane targeting of the BBSome by ARL6

(2014) André Mourão et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Gain-of-Function Mutation in Adenylate Cyclase 3 Protects Mice from Diet-Induced Obesity

(2014) Jeffrey L. Pitman et al.   PLoS One

Primary cilia enhance kisspeptin receptor signaling on gonadotropin-releasing hormone neurons

(2014) A. I. Koemeter-Cox et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long-range transcriptional regulation by the p110 CUX1 homeodomain protein on the ENCODE array

(2013) Charles Vadnais et al.   BMC GENOMICS

BBS7 is required for BBSome formation and its absence in mice results in Bardet-Biedl syndrome phenotypes and selective abnormalities in membrane protein trafficking

(2013) Q. Zhang et al.   JOURNAL OF CELL SCIENCE

The endocrinology of food intake

(2013) Denovan P. Begg et al.   Nature Reviews Endocrinology

Leptin resistance is a secondary consequence of the obesity in ciliopathy mutant mice

(2013) N. F. Berbari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuropeptide Y Family Receptors Traffic via the Bardet-Biedl Syndrome Pathway to Signal in Neuronal Primary Cilia

(2013) Alexander V. Loktev et al.   Cell Reports

Hedgehog Partial Agonism Drives Warburg-like Metabolism in Muscle and Brown Fat

(2012) Raffaele Teperino et al.   CELL

BBS-Induced Ciliary Defect Enhances Adipogenesis, Causing Paradoxical Higher-Insulin Sensitivity, Glucose Usage, and Decreased Inflammatory Response

(2012) Vincent Marion et al.   Cell Metabolism

AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In Vivo

(2012) Brandon Faubert et al.   Cell Metabolism

A truncating mutation of Alms1 reduces the number of hypothalamic neuronal cilia in obese mice

(2012) Déborah Heydet et al.   Developmental Neurobiology

Bardet–Biedl syndrome

(2012) Elizabeth Forsythe et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Differential function of Akt1 and Akt2 in human adipocytes

(2012) Pamela Fischer-Posovszky et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Caenorhabditis elegans ciliary protein NPHP-8, the homologue of human RPGRIP1L, is required for ciliogenesis and chemosensation

(2011) Lin Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MKS and NPHP modules cooperate to establish basal body/transition zone membrane associations and ciliary gate function during ciliogenesis

(2011) Corey L. Williams et al.   JOURNAL OF CELL BIOLOGY

Loss of Bardet-Biedl syndrome protein-8 (BBS8) perturbs olfactory function, protein localization, and axon targeting

(2011) A. L. D. Tadenev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bardet-Biedl syndrome 3 (Bbs3) knockout mouse model reveals common BBS-associated phenotypes and Bbs3 unique phenotypes

(2011) Q. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Conserved Bardet-Biedl Syndrome Proteins Assemble a Coat that Traffics Membrane Proteins to Cilia

(2010) Hua Jin et al.   CELL

Dopamine receptor 1 localizes to neuronal cilia in a dynamic process that requires the Bardet-Biedl syndrome proteins

(2010) Jacqueline S. Domire et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cut-like Homeobox 1 (CUX1) Regulates Expression of the Fat Mass and Obesity-associated and Retinitis Pigmentosa GTPase Regulator-interacting Protein-1-like (RPGRIP1L) Genes and Coordinates Leptin Receptor Signaling

(2010) George Stratigopoulos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Centriolar Association of ALMS1 and Likely Centrosomal Functions of the ALMS Motif–containing Proteins C10orf90 and KIAA1731

(2010) Victoria J. Knorz et al.   MOLECULAR BIOLOGY OF THE CELL

Primary cilia regulate mTORC1 activity and cell size through Lkb1

(2010) Christopher Boehlke et al.   NATURE CELL BIOLOGY

Alström syndrome: insights into the pathogenesis of metabolic disorders

(2010) Dorothée Girard et al.   Nature Reviews Endocrinology

DISC1 Regulates Primary Cilia That Display Specific Dopamine Receptors

(2010) Aaron Marley et al.   PLoS One

Sonic Hedgehog Influences the Balance of Osteogenesis and Adipogenesis in Mouse Adipose-Derived Stromal Cells

(2010) Aaron W. James et al.   TISSUE ENGINEERING PART A

Obesity and leptin resistance: distinguishing cause from effect

(2010) Martin G. Myers et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Prevalence of Loss-of-Function FTO Mutations in Lean and Obese Individuals

(2009) D. Meyre et al.   DIABETES

Food-anticipatory circadian rhythms: concepts and methods

(2009) Ralph E. Mistlberger   EUROPEAN JOURNAL OF NEUROSCIENCE

Deficiency of the E3 ubiquitin ligase TRIM32 in mice leads to a myopathy with a neurogenic component

(2009) Elena Kudryashova et al.   HUMAN MOLECULAR GENETICS

Requirement of Bardet-Biedl syndrome proteins for leptin receptor signaling

(2009) Seongjin Seo et al.   HUMAN MOLECULAR GENETICS

Growth arrest induces primary-cilium formation and sensitizes IGF-1-receptor signaling during differentiation induction of 3T3-L1 preadipocytes

(2009) D. Zhu et al.   JOURNAL OF CELL SCIENCE

Adult Type 3 Adenylyl Cyclase–Deficient Mice Are Obese

(2009) Zhenshan Wang et al.   PLoS One

Transient ciliogenesis involving Bardet-Biedl syndrome proteins is a fundamental characteristic of adipogenic differentiation

(2009) Vincent Marion et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leptin resistance contributes to obesity and hypertension in mouse models of Bardet-Biedl syndrome

(2008) Kamal Rahmouni et al.   JOURNAL OF CLINICAL INVESTIGATION

Bardet-Biedl syndrome proteins are required for the localization of G protein-coupled receptors to primary cilia

(2008) N. F. Berbari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hedgehog Signaling Alters Adipocyte Maturation of Human Mesenchymal Stem Cells

(2008) Coralie Fontaine et al.   STEM CELLS