Pro-Opiomelanocortin (POMC) Neurones, POMC-Derived Peptides, Melanocortin Receptors and Obesity: How Understanding of this System has Changed Over the Last Decade

G-protein-independent coupling of MC4R to Kir7.1 in hypothalamic neurons

(2015) Masoud Ghamari-Langroudi et al.   NATURE

Hypothalamic POMC neurons promote cannabinoid-induced feeding

(2015) Marco Koch et al.   NATURE

The Melanocortin-4 Receptor Is Expressed in Enteroendocrine L Cells and Regulates the Release of Peptide YY and Glucagon-like Peptide 1 In Vivo

(2014) Brandon L. Panaro et al.   Cell Metabolism

Insulin Excites Anorexigenic Proopiomelanocortin Neurons via Activation of Canonical Transient Receptor Potential Channels

(2014) Jian Qiu et al.   Cell Metabolism

Visualization of arrestin recruitment by a G-protein-coupled receptor

(2014) Arun K. Shukla et al.   NATURE

An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger

(2014) Michael J. Krashes et al.   NATURE

Melanocortin 4 receptors in autonomic neurons regulate thermogenesis and glycemia

(2014) Eric D Berglund et al.   NATURE NEUROSCIENCE

Activation of MAPK by inverse agonists in six naturally occurring constitutively active mutant human melanocortin-4 receptors

(2013) Xiu-Lei Mo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Parallel, Redundant Circuit Organization for Homeostatic Control of Feeding Behavior

(2013) J. Nicholas Betley et al.   CELL

Melanocortin 4 Receptors Reciprocally Regulate Sympathetic and Parasympathetic Preganglionic Neurons

(2013) Jong-Woo Sohn et al.   CELL

Glutamate Mediates the Function of Melanocortin Receptor 4 on Sim1 Neurons in Body Weight Regulation

(2013) Yuanzhong Xu et al.   Cell Metabolism

Hypothalamic and brainstem neuronal circuits controlling homeostatic energy balance

(2013) Marc Schneeberger et al.   JOURNAL OF ENDOCRINOLOGY

hMRAPa increases αMSH-induced hMC1R and hMC3R functional coupling and hMC4R constitutive activity

(2013) Emma I Kay et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

hMRAPa specifically alters hMC4R molecular mass and N-linked complex glycosylation in HEK293 cells

(2013) Emma I Kay et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Loss of NSCL-2 in Gonadotropin Releasing Hormone Neurons Leads to Reduction of Pro-Opiomelanocortin Neurons in Specific Hypothalamic Nuclei and Causes Visceral Obesity

(2013) T. Schmid et al.   JOURNAL OF NEUROSCIENCE

5-HT2C Receptor Agonist Anorectic Efficacy Potentiated by 5-HT1B Receptor Agonist Coapplication: An Effect Mediated via Increased Proportion of Pro-Opiomelanocortin Neurons Activated

(2013) B. Doslikova et al.   JOURNAL OF NEUROSCIENCE

Acute and Long-Term Suppression of Feeding Behavior by POMC Neurons in the Brainstem and Hypothalamus, Respectively

(2013) C. Zhan et al.   JOURNAL OF NEUROSCIENCE

Developmental Control of the Melanocortin-4 Receptor by MRAP2 Proteins in Zebrafish

(2013) J. A. Sebag et al.   SCIENCE

Loss of Function of the Melanocortin 2 Receptor Accessory Protein 2 Is Associated with Mammalian Obesity

(2013) M. Asai et al.   SCIENCE

Hypothalamic control of energy balance: insights into the role of synaptic plasticity

(2013) Marcelo O. Dietrich et al.   TRENDS IN NEUROSCIENCES

Loss of Autophagy in Pro-opiomelanocortin Neurons Perturbs Axon Growth and Causes Metabolic Dysregulation

(2012) Bérengère Coupé et al.   Cell Metabolism

Gsα Deficiency in the Paraventricular Nucleus of the Hypothalamus Partially Contributes to Obesity Associated with Gsα Mutations

(2012) Min Chen et al.   ENDOCRINOLOGY

Role of Hypothalamic Proopiomelanocortin Neuron Autophagy in the Control of Appetite and Leptin Response

(2012) Wenying Quan et al.   ENDOCRINOLOGY

AgRP Innervation onto POMC Neurons Increases with Age and Is Accelerated with Chronic High-Fat Feeding in Male Mice

(2012) A. Jamila Newton et al.   ENDOCRINOLOGY

Weight-Independent Effects of Roux-en-Y Gastric Bypass on Glucose Homeostasis via Melanocortin-4 Receptors in Mice and Humans

(2012) Juliet F. Zechner et al.   GASTROENTEROLOGY

Deconstruction of a neural circuit for hunger

(2012) Deniz Atasoy et al.   NATURE

Fasting Activation of AgRP Neurons Requires NMDA Receptors and Involves Spinogenesis and Increased Excitatory Tone

(2012) Tiemin Liu et al.   NEURON

Hunger States Switch a Flip-Flop Memory Circuit via a Synaptic AMPK-Dependent Positive Feedback Loop

(2011) Yunlei Yang et al.   CELL

Autophagy in Hypothalamic AgRP Neurons Regulates Food Intake and Energy Balance

(2011) Susmita Kaushik et al.   Cell Metabolism

Melanocortin-4 Receptors Expressed by Cholinergic Neurons Regulate Energy Balance and Glucose Homeostasis

(2011) Jari Rossi et al.   Cell Metabolism

Defining POMC Neurons Using Transgenic Reagents: Impact of TransientPomcExpression in Diverse Immature Neuronal Populations

(2011) Stephanie L. Padilla et al.   ENDOCRINOLOGY

Simultaneous POMC gene transfer to hypothalamus and brainstem increases physical activity, lipolysis and reduces adult-onset obesity

(2011) Yi Zhang et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Genetic Dissection of the Functions of the Melanocortin-3 Receptor, a Seven-transmembrane G-protein-coupled Receptor, Suggests Roles for Central and Peripheral Receptors in Energy Homeostasis

(2011) Karima Begriche et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training

(2011) Yexica Aponte et al.   NATURE NEUROSCIENCE

Serotonin 2C Receptor Activates a Distinct Population of Arcuate Pro-opiomelanocortin Neurons via TRPC Channels

(2011) Jong-Woo Sohn et al.   NEURON

Leptin Action on GABAergic Neurons Prevents Obesity and Reduces Inhibitory Tone to POMC Neurons

(2011) Linh Vong et al.   NEURON

Expression of genes involved in energy homeostasis in the duodenum and liver of Holstein-Friesian and Jersey cows and their F1 hybrid

(2011) Tanweer Alam et al.   PHYSIOLOGICAL GENOMICS

Homeostastic and non-homeostatic functions of melanocortin-3 receptors in the control of energy balance and metabolism

(2011) Karima Begriche et al.   PHYSIOLOGY & BEHAVIOR

Functions for pro-opiomelanocortin-derived peptides in obesity and diabetes

(2010) Kathleen G. Mountjoy   BIOCHEMICAL JOURNAL

An intrinsic gut leptin-melanocortin pathway modulates intestinal microsomal triglyceride transfer protein and lipid absorption

(2010) Jahangir Iqbal et al.   JOURNAL OF LIPID RESEARCH

Segregation of Acute Leptin and Insulin Effects in Distinct Populations of Arcuate Proopiomelanocortin Neurons

(2010) K. W. Williams et al.   JOURNAL OF NEUROSCIENCE

Pro-opiomelanocortin gene transfer to the nucleus of the solitary track but not arcuate nucleus ameliorates chronic diet-induced obesity

(2010) Y. Zhang et al.   NEUROSCIENCE

Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity

(2010) T. L. Horvath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of G Protein-Coupled Receptor Signaling: Specific Dominant-Negative Effects of Melanocortin 2 Receptor Accessory Protein 2

(2010) J. A. Sebag et al.   Science Signaling

Stirring Up New Ideas About the Regulation of the Hypothalamic-Pituitary-Interrenal Axis in Zebrafish (Danio rerio)

(2010) Meghan L.M. Fuzzen et al.   Zebrafish

Central Nervous System Imprinting of the G Protein Gsα and Its Role in Metabolic Regulation

(2009) Min Chen et al.   Cell Metabolism

New ligands for melanocortin receptors

(2009) C B Kaelin et al.   INTERNATIONAL JOURNAL OF OBESITY

Opposite Effects of the Melanocortin-2 (MC2) Receptor Accessory Protein MRAP on MC2 and MC5 Receptor Dimerization and Trafficking

(2009) Julien A. Sebag et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pertussis Toxin-sensitive Signaling of Melanocortin-4 Receptors in Hypothalamic GT1-7 Cells Defines Agouti-related Protein as a Biased Agonist

(2009) Thomas R. H. Büch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proopiomelanocortin Expression in both GABA and Glutamate Neurons

(2009) S. T. Hentges et al.   JOURNAL OF NEUROSCIENCE

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

The genetic contribution to non-syndromic human obesity

(2009) Andrew J. Walley et al.   NATURE REVIEWS GENETICS

MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family

(2009) L. F. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

UCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicals

(2008) Zane B. Andrews et al.   NATURE

Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance

(2008) Qingchun Tong et al.   NATURE NEUROSCIENCE

Starvation after AgRP neuron ablation is independent of melanocortin signaling

(2008) Q. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Collective and Individual Functions of Leptin Receptor Modulated Neurons Controlling Metabolism and Ingestion

(2007) Esther van de Wall et al.   ENDOCRINOLOGY