Discovery of potent human lactate dehydrogenase A (LDHA) inhibitors with antiproliferative activity against lung cancer cells: virtual screening and biological evaluation
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Title
Discovery of potent human lactate dehydrogenase A (LDHA) inhibitors with antiproliferative activity against lung cancer cells: virtual screening and biological evaluation
Authors
Keywords
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Journal
MedChemComm
Volume 8, Issue 3, Pages 599-605
Publisher
Royal Society of Chemistry (RSC)
Online
2017-01-14
DOI
10.1039/c6md00670a
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- Identification of N-acylhydrazone derivatives as novel lactate dehydrogenase A inhibitors
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- Targeting Lactate Dehydrogenase-A Inhibits Tumorigenesis and Tumor Progression in Mouse Models of Lung Cancer and Impacts Tumor-Initiating Cells
- (2014) Han Xie et al. Cell Metabolism
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- (2014) J. Cui et al. CLINICAL CANCER RESEARCH
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- Design and Synthesis of Novel Lactate Dehydrogenase A Inhibitors by Fragment-Based Lead Generation
- (2012) Richard A. Ward et al. JOURNAL OF MEDICINAL CHEMISTRY
- LDH-A silencing suppresses breast cancer tumorigenicity through induction of oxidative stress mediated mitochondrial pathway apoptosis
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- Discovery ofN-Hydroxyindole-Based Inhibitors of Human Lactate Dehydrogenase Isoform A (LDH-A) as Starvation Agents against Cancer Cells
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- Interfering with pH regulation in tumours as a therapeutic strategy
- (2011) Dario Neri et al. NATURE REVIEWS DRUG DISCOVERY
- Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression
- (2010) A. Le et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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