Development of small molecular compounds targeting cancer stem cells

T-LAK Cell-Originated Protein Kinase (TOPK) as a Prognostic Factor and a Potential Therapeutic Target in Ovarian Cancer

(2016) Y. Ikeda et al.   CLINICAL CANCER RESEARCH

Effective growth-suppressive activity of maternal embryonic leucine-zipper kinase (MELK) inhibitor against small cell lung cancer

(2016) Hiroyuki Inoue et al.   Oncotarget

Preclinical evaluation of biomarkers associated with antitumor activity of MELK inhibitor

(2016) Suyoun Chung et al.   Oncotarget

Oncogenic roles of TOPK and MELK, and effective growth suppression by small molecular inhibitors in kidney cancer cells

(2016) Taigo Kato et al.   Oncotarget

Therapeutic strategies targeting cancer stem cells

(2015) Go J. Yoshida et al.   CANCER SCIENCE

Discovery of Imidazo[1,2-b]pyridazine Derivatives: Selective and Orally Available Mps1 (TTK) Kinase Inhibitors Exhibiting Remarkable Antiproliferative Activity

(2015) Ken-ichi Kusakabe et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Discovery of Orally Bioavailable Tyrosine Threonine Kinase (TTK) Inhibitors: 3-(4-(heterocyclyl)phenyl)-1H-indazole-5-carboxamides as Anticancer Agents

(2015) Yong Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting PBK/TOPK decreases growth and survival of glioma initiating cells in vitro and attenuates tumor growth in vivo

(2015) Mrinal Joel et al.   Molecular Cancer

Targeting Mitosis in Cancer: Emerging Strategies

(2015) Carmen Dominguez-Brauer et al.   MOLECULAR CELL

Targeting Notch, Hedgehog and Wnt pathways in cancer stem cells: clinical update

(2015) Naoko Takebe et al.   Nature Reviews Clinical Oncology

T-LAK cell-originated protein kinase presents a novel therapeutic target in FLT3-ITD mutated acute myeloid leukemia

(2015) Houda Alachkar et al.   Oncotarget

Combined expressional analysis, bioinformatics and targeted proteomics identify new potential therapeutic targets in glioblastoma stem cells

(2015) Biljana Stangeland et al.   Oncotarget

Maternal embryonic leucine zipper kinase serves as a poor prognosis marker and therapeutic target in gastric cancer

(2015) Shen Li et al.   Oncotarget

Development of an orally-administrative MELK-targeting inhibitor that suppresses the growth of various types of human cancer

(2015) Suyoun Chung et al.   Oncotarget

Preclinical efficacy of maternal embryonic leucine-zipper kinase (MELK) inhibition in acute myeloid leukemia

(2015) Houda Alachkar et al.   Oncotarget

Evolution of the Cancer Stem Cell Model

(2014) Antonija Kreso et al.   Cell Stem Cell

Tackling the cancer stem cells — what challenges do they pose?

(2014) Diwakar R. Pattabiraman et al.   NATURE REVIEWS DRUG DISCOVERY

TOPK inhibitor induces complete tumor regression in xenograft models of human cancer through inhibition of cytokinesis

(2014) Y. Matsuo et al.   Science Translational Medicine

ALDH1 activity identifies tumor-initiating cells and links to chromosomal instability signatures in multiple myeloma

(2013) W Zhou et al.   LEUKEMIA

MELK-Dependent FOXM1 Phosphorylation is Essential for Proliferation of Glioma Stem Cells

(2013) Kaushal Joshi et al.   STEM CELLS

Molecular features of triple negative breast cancer cells by genome-wide gene expression profiling analysis

(2012) MASATO KOMATSU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Multicenter, phase II clinical trial of cancer vaccination for advanced esophageal cancer with three peptides derived from novel cancer-testis antigens

(2012) Koji Kono et al.   Journal of Translational Medicine

Cancer stromal targeting (CAST) therapy

(2011) Yasuhiro Matsumura   ADVANCED DRUG DELIVERY REVIEWS

Characterization of an Opa interacting protein 5 involved in lung and esophageal carcinogenesis

(2011) Junkichi Koinuma et al.   CANCER SCIENCE

Concise Review: Cancer Stem Cells and Minimal Residual Disease

(2011) Gabriel Ghiaur et al.   STEM CELLS

Maternal Embryonic Leucine Zipper Kinase Is Upregulated and Required in Mammary Tumor-Initiating Cells In vivo

(2010) L. W. Hebbard et al.   CANCER RESEARCH

Using a Stem Cell-Based Signature to Guide Therapeutic Selection in Cancer

(2010) I. Shats et al.   CANCER RESEARCH

Critical roles of LGN/GPSM2 phosphorylation by PBK/TOPK in cell division of breast cancer cells

(2010) Chikako Fukukawa et al.   GENES CHROMOSOMES & CANCER

The therapeutic promise of the cancer stem cell concept

(2010) Natasha Y. Frank et al.   JOURNAL OF CLINICAL INVESTIGATION

Vaccination with multiple peptides derived from novel cancer-testis antigens can induce specific T-cell responses and clinical responses in advanced esophageal cancer

(2009) Koji Kono et al.   CANCER SCIENCE

Critical roles of T-LAK cell-originated protein kinase in cytokinesis

(2009) Jae-Hyun Park et al.   CANCER SCIENCE

Detection of novel cancer-testis antigen-specific T-cell responses in TIL, regional lymph nodes, and PBL in patients with esophageal squamous cell carcinoma

(2008) Yoshiki Mizukami et al.   CANCER SCIENCE

Involvement of Epithelial Cell Transforming Sequence-2 Oncoantigen in Lung and Esophageal Cancer Progression

(2008) D. Hirata et al.   CLINICAL CANCER RESEARCH

Involvement of elevated expression of multiple cell-cycle regulator, DTL/RAMP (denticleless/RA-regulated nuclear matrix associated protein), in the growth of breast cancer cells

(2008) T Ueki et al.   ONCOGENE

Isolation and Identification of Cancer Stem-Like Cells in Esophageal Carcinoma Cell Lines

(2008) Dingzhi Huang et al.   STEM CELLS AND DEVELOPMENT