Understanding the Role of GPCR Heteroreceptor Complexes in Modulating the Brain Networks in Health and Disease
Published 2017 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Understanding the Role of GPCR Heteroreceptor Complexes in Modulating the Brain Networks in Health and Disease
Authors
Keywords
-
Journal
Frontiers in Cellular Neuroscience
Volume 11, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2017-02-21
DOI
10.3389/fncel.2017.00037
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Signaling in dopamine D2 receptor-oxytocin receptor heterocomplexes and its relevance for the anxiolytic effects of dopamine and oxytocin interactions in the amygdala of the rat
- (2016) Miguel Pérez de la Mora et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Galanin (1–15) enhances the antidepressant effects of the 5-HT1A receptor agonist 8-OH-DPAT: involvement of the raphe-hippocampal 5-HT neuron system
- (2016) Carmelo Millón et al. Brain Structure & Function
- Structure-Based Rational Design of Adenosine Receptor Ligands
- (2016) Hugo Gutiérrez-de-Terán et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Cell- and region-specific expression of depression-related protein p11 (S100a10) in the brain
- (2016) Ana Milosevic et al. JOURNAL OF COMPARATIVE NEUROLOGY
- Blocking Synaptic Removal of GluA2-Containing AMPA Receptors Prevents the Natural Forgetting of Long-Term Memories
- (2016) P. V. Migues et al. JOURNAL OF NEUROSCIENCE
- Cross-talk between α7 nAchR and NMDAR revealed by protein profiling
- (2016) Hailong Zhang et al. Journal of Proteomics
- Alterations in ventral and dorsal striatal allosteric A2AR-D2R receptor-receptor interactions after amphetamine challenge: Relevance for schizophrenia
- (2016) Julia Pintsuk et al. LIFE SCIENCES
- Metabotropic glutamate receptors as targets for new antipsychotic drugs: Historical perspective and critical comparative assessment
- (2016) Joanna M. Wierońska et al. PHARMACOLOGY & THERAPEUTICS
- Cocaine self-administration differentially affects allosteric A2A-D2 receptor-receptor interactions in the striatum. Relevance for cocaine use disorder
- (2016) Julia Pintsuk et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- p11 modulates L-DOPA therapeutic effects and dyskinesia via distinct cell types in experimental Parkinsonism
- (2016) Nicoletta Schintu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- FGFR1–5-HT1A Heteroreceptor Complexes: Implications for Understanding and Treating Major Depression
- (2016) Dasiel O. Borroto-Escuela et al. TRENDS IN NEUROSCIENCES
- Structure-guided development of heterodimer-selective GPCR ligands
- (2016) Harald Hübner et al. Nature Communications
- Three-Dimensional Study of Alzheimer’s Disease Hallmarks Using the iDISCO Clearing Method
- (2016) Thomas Liebmann et al. Cell Reports
- Understanding the Functional Plasticity in Neural Networks of the Basal Ganglia in Cocaine Use Disorder: A Role for Allosteric Receptor-Receptor Interactions in A2A-D2 Heteroreceptor Complexes
- (2016) Dasiel O. Borroto-Escuela et al. NEURAL PLASTICITY
- Study of antidepressant drugs in GPR39 (zinc receptor−/−) knockout mice, showing no effect of conventional antidepressants, but effectiveness of NMDA antagonists
- (2015) Katarzyna Młyniec et al. BEHAVIOURAL BRAIN RESEARCH
- Evidence for the existence of FGFR1–5-HT1A heteroreceptor complexes in the midbrain raphe 5-HT system
- (2015) Dasiel O. Borroto-Escuela et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Enhancement of the FGFR1 signaling in the FGFR1-5-HT1A heteroreceptor complex in midbrain raphe 5-HT neuron systems. Relevance for neuroplasticity and depression
- (2015) Dasiel O. Borroto-Escuela et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The zinc binding receptor GPR39 interacts with 5-HT1A and GalR1 to form dynamic heteroreceptor complexes with signaling diversity
- (2015) Mercè Tena-Campos et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Developments in the field of antidepressants, where do we go now?
- (2015) Francesc Artigas EUROPEAN NEUROPSYCHOPHARMACOLOGY
- Basimglurant for treatment of major depressive disorder: a novel negative allosteric modulator of metabotropic glutamate receptor 5
- (2015) Kjell Fuxe et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- A Role for Galanin N-Terminal Fragment (1–15) in Anxiety- and Depression-Related Behaviors in Rats
- (2015) Carmelo Millón et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- Zinc Is Involved in Depression by Modulating G Protein-Coupled Receptor Heterodimerization
- (2015) Mercè Tena-Campos et al. MOLECULAR NEUROBIOLOGY
- Heteroreceptor Complexes and their Allosteric Receptor–Receptor Interactions as a Novel Biological Principle for Integration of Communication in the CNS: Targets for Drug Development
- (2015) Kjell Fuxe et al. NEUROPSYCHOPHARMACOLOGY
- The role of transmitter diffusion and flow versus extracellular vesicles in volume transmission in the brain neural–glial networks
- (2015) Dasiel O. Borroto-Escuela et al. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
- Evidence for the existence of dopamine D2R and Sigma 1 allosteric receptor-receptor interaction in the rat brain: role in brain plasticity and cocaine action
- (2015) Luca Pinton et al. SpringerPlus
- Preferential activation by galanin 1–15 fragment of the GalR1 protomer of a GalR1–GalR2 heteroreceptor complex
- (2014) Dasiel O. Borroto-Escuela et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Deep Brain Stimulation in Major Depression: Plastic Changes of 5-Hydroxytryptamine Neurons
- (2014) Francesc Artigas BIOLOGICAL PSYCHIATRY
- Reductions of p11 and 5-HT1B Receptor Availability in Limbic Brain Regions in Cocaine Dependence
- (2014) Per Svenningsson BIOLOGICAL PSYCHIATRY
- Antidepressant-like Effects of Cortical Deep Brain Stimulation Coincide With Pro-neuroplastic Adaptations of Serotonin Systems
- (2014) Avin Veerakumar et al. BIOLOGICAL PSYCHIATRY
- Editorial (Thematic Issue: Understanding the Role of Heteroreceptor Complexes in the Central Nervous System)
- (2014) Kjell Fuxe et al. CURRENT PROTEIN & PEPTIDE SCIENCE
- Neurotensin NTS1-Dopamine D2 Receptor-Receptor Interactions in Putative Receptor Heteromers: Relevance for Parkinson’s Disease and Schizophrenia
- (2014) Luca Ferraro et al. CURRENT PROTEIN & PEPTIDE SCIENCE
- Dopamine heteroreceptor complexes as therapeutic targets in Parkinson’s disease
- (2014) Kjell Fuxe et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- G-protein-coupled receptor type A heteromers as an emerging therapeutic target
- (2014) Diego Guidolin et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- The impact of receptor–receptor interactions in heteroreceptor complexes on brain plasticity
- (2014) Kjell Fuxe et al. Expert Review of Neurotherapeutics
- The G Protein-Coupled Receptor Heterodimer Network (GPCR-HetNet) and Its Hub Components
- (2014) Dasiel Borroto-Escuela et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- A Dopamine D2 Receptor-DISC1 Protein Complex may Contribute to Antipsychotic-Like Effects
- (2014) Ping Su et al. NEURON
- On the role of adenosine (A)2A receptors in cocaine-induced reward: a pharmacological and neurochemical analysis in rats
- (2014) Karolina Wydra et al. PSYCHOPHARMACOLOGY
- On the role of A2A and D2 receptors in control of cocaine and food-seeking behaviors in rats
- (2014) Karolina Wydra et al. PSYCHOPHARMACOLOGY
- Dopaminergic basis of salience dysregulation in psychosis
- (2014) Toby T. Winton-Brown et al. TRENDS IN NEUROSCIENCES
- Diversity and Bias through Receptor–Receptor Interactions in GPCR Heteroreceptor Complexes. Focus on Examples from Dopamine D2 Receptor Heteromerization
- (2014) Kjell Fuxe et al. Frontiers in Endocrinology
- Dopamine D2 receptor signaling dynamics of dopamine D2-neurotensin 1 receptor heteromers
- (2013) Dasiel O. Borroto-Escuela et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Dynamic modulation of FGFR1–5-HT1A heteroreceptor complexes. Agonist treatment enhances participation of FGFR1 and 5-HT1A homodimers and recruitment of β-arrestin2
- (2013) Dasiel O. Borroto-Escuela et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Hallucinogenic 5-HT2AR agonists LSD and DOI enhance dopamine D2R protomer recognition and signaling of D2-5-HT2A heteroreceptor complexes
- (2013) Dasiel O. Borroto-Escuela et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Dynamic Interaction between Sigma-1 Receptor and Kv1.2 Shapes Neuronal and Behavioral Responses to Cocaine
- (2013) Saïd Kourrich et al. CELL
- Serotonin 5-HT1A Receptors as Targets for Agents to Treat Psychiatric Disorders: Rationale and Current Status of Research
- (2013) Pau Celada et al. CNS DRUGS
- Bivalent Ligands That Target μ Opioid (MOP) and Cannabinoid1 (CB1) Receptors Are Potent Analgesics Devoid of Tolerance
- (2013) Morgan Le Naour et al. JOURNAL OF MEDICINAL CHEMISTRY
- p11 and its role in depression and therapeutic responses to antidepressants
- (2013) Per Svenningsson et al. NATURE REVIEWS NEUROSCIENCE
- Moonlighting Proteins and Protein–Protein Interactions as Neurotherapeutic Targets in the G Protein-Coupled Receptor Field
- (2013) Kjell Fuxe et al. NEUROPSYCHOPHARMACOLOGY
- Cocaine Inhibits Dopamine D2 Receptor Signaling via Sigma-1-D2 Receptor Heteromers
- (2013) Gemma Navarro et al. PLoS One
- Effects of cocaine self-administration and extinction on D2-like and A2Areceptor recognition and D2-like/Giprotein coupling in rat striatum
- (2012) Malgorzata Frankowska et al. ADDICTION BIOLOGY
- The role of the GPR39 receptor in zinc deficient-animal model of depression
- (2012) Katarzyna Młyniec et al. BEHAVIOURAL BRAIN RESEARCH
- Detection of antigen interactions ex vivo by proximity ligation assay: endogenous dopamine D2-adenosine A2A receptor complexes in the striatum
- (2012) Pierre Trifilieff et al. BIOTECHNIQUES
- On the role of volume transmission and receptor–receptor interactions in social behaviour: Focus on central catecholamine and oxytocin neurons
- (2012) Kjell Fuxe et al. BRAIN RESEARCH
- Relevance of Dopamine D2/Neurotensin NTS1 and NMDA/Neurotensin NTS1 Receptor Interaction in Psychiatric and Neurodegenerative Disorders
- (2012) S. Tanganelli et al. CURRENT MEDICINAL CHEMISTRY
- The Importance of the Adenosine A2A Receptor-Dopamine D2 Receptor Interaction in Drug Addiction
- (2012) M. Filip et al. CURRENT MEDICINAL CHEMISTRY
- GPCR Heteromers and their Allosteric Receptor-Receptor Interactions
- (2012) K. Fuxe et al. CURRENT MEDICINAL CHEMISTRY
- Heterodimerization of serotonin receptors 5-HT1A and 5-HT7 differentially regulates receptor signalling and trafficking
- (2012) U. Renner et al. JOURNAL OF CELL SCIENCE
- Evidence for the existence of dopamine d2-oxytocin receptor heteromers in the ventral and dorsal striatum with facilitatory receptor–receptor interactions
- (2012) W Romero-Fernandez et al. MOLECULAR PSYCHIATRY
- Apo-Ghrelin Receptor Forms Heteromers with DRD2 in Hypothalamic Neurons and Is Essential for Anorexigenic Effects of DRD2 Agonism
- (2012) Andras Kern et al. NEURON
- Serotonin receptors involved in antidepressant effects
- (2012) Francesc Artigas PHARMACOLOGY & THERAPEUTICS
- Serotonin–glutamate and serotonin–dopamine reciprocal interactions as putative molecular targets for novel antipsychotic treatments: from receptor heterodimers to postsynaptic scaffolding and effector proteins
- (2012) A. de Bartolomeis et al. PSYCHOPHARMACOLOGY
- On the existence and function of galanin receptor heteromers in the central nervous system
- (2012) Kjell Fuxe et al. Frontiers in Endocrinology
- Cross-Receptor Interactions between Dopamine D2L and Neurotensin NTS1 Receptors Modulate Binding Affinities of Dopaminergics
- (2011) Susanne Koschatzky et al. ACS Chemical Neuroscience
- Pimavanserin, a 5-HT2A inverse agonist, reverses psychosis-like behaviors in a rodent model of Parkinsonʼs disease
- (2011) Krista McFarland et al. BEHAVIOURAL PHARMACOLOGY
- Fibroblast Growth Factor Receptor 1– 5-Hydroxytryptamine 1A Heteroreceptor Complexes and Their Enhancement of Hippocampal Plasticity
- (2011) Dasiel O. Borroto-Escuela et al. BIOLOGICAL PSYCHIATRY
- Bivalent molecular probes for dopamine D2-like receptors
- (2011) Daniela Huber et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Muscarinic Acetylcholine Receptor-Interacting Proteins (mAChRIPs): Targeting the Receptorsome
- (2011) D. O. Borroto-Escuela et al. CURRENT DRUG TARGETS
- Striatal NTS1, dopamine D2 and NMDA receptor regulation of pallidal GABA and glutamate release - a dual-probe microdialysis study in the intranigral 6-hydroxydopamine unilaterally lesioned rat
- (2011) Luca Ferraro et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Dopamine D4 receptor oligomerization - contribution to receptor biogenesis
- (2011) Kathleen Van Craenenbroeck et al. FEBS Journal
- Moonlighting characteristics of G protein-coupled receptors: Focus on receptor heteromers and relevance for neurodegeneration
- (2011) Dasiel O. Borroto-Escuela et al. IUBMB LIFE
- Functional Interaction between Trace Amine-Associated Receptor 1 and Dopamine D2 Receptor
- (2011) S. Espinoza et al. MOLECULAR PHARMACOLOGY
- Functional crosstalk and heteromerization of serotonin 5-HT2A and dopamine D2 receptors
- (2011) Laura Albizu et al. NEUROPHARMACOLOGY
- Oxytocin as a Potential Therapeutic Target for Schizophrenia and Other Neuropsychiatric Conditions
- (2011) David Feifel NEUROPSYCHOPHARMACOLOGY
- Addiction: Beyond dopamine reward circuitry
- (2011) N. D. Volkow et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Characterization of the A2AR–D2R interface: Focus on the role of the C-terminal tail and the transmembrane helices
- (2010) Dasiel O. Borroto-Escuela et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Galanin receptor-1 modulates 5-hydroxtryptamine-1A signaling via heterodimerization
- (2010) Dasiel O. Borroto-Escuela et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Dopamine D2 and 5-hydroxytryptamine 5-HT2A receptors assemble into functionally interacting heteromers
- (2010) Dasiel O. Borroto-Escuela et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- A serine point mutation in the adenosine A2AR C-terminal tail reduces receptor heteromerization and allosteric modulation of the dopamine D2R
- (2010) Dasiel O. Borroto-Escuela et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Dopamine D2 and D4 receptor heteromerization and its allosteric receptor–receptor interactions
- (2010) Dasiel O. Borroto-Escuela et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Adjunctive Intranasal Oxytocin Reduces Symptoms in Schizophrenia Patients
- (2010) David Feifel et al. BIOLOGICAL PSYCHIATRY
- Understanding wiring and volume transmission
- (2010) Luigi F. Agnati et al. BRAIN RESEARCH REVIEWS
- Adenosine-Dopamine Interactions in the Pathophysiology and Treatment of CNS Disorders
- (2010) K. Fuxe et al. CNS Neuroscience & Therapeutics
- Dopamine D1-D2 Receptor Heteromer-mediated Calcium Release Is Desensitized by D1 Receptor Occupancy with or without Signal Activation
- (2010) Vaneeta Verma et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Functional Selectivity and Biased Receptor Signaling
- (2010) T. Kenakin JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Direct involvement of -1 receptors in the dopamine D1 receptor-mediated effects of cocaine
- (2010) G. Navarro et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Schizophrenia, amphetamine-induced sensitized state and acute amphetamine exposure all show a common alteration: increased dopamine D2 receptor dimerization
- (2010) Min Wang et al. Molecular Brain
- GPR37 Surface Expression Enhancement via N-Terminal Truncation or Protein−Protein Interactions
- (2009) Jill H. Dunham et al. BIOCHEMISTRY
- Adenosine A2AReceptor-Antagonist/Dopamine D2Receptor-Agonist Bivalent Ligands as Pharmacological Tools to Detect A2A-D2Receptor Heteromers
- (2009) Aroa Soriano et al. JOURNAL OF MEDICINAL CHEMISTRY
- Triplet Puzzle: Homologies of Receptor Heteromers
- (2009) Alexander O. Tarakanov et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Metabotropic glutamate type 5, dopamine D2and adenosine A2areceptors form higher-order oligomers in living cells
- (2009) Nuria Cabello et al. JOURNAL OF NEUROCHEMISTRY
- Ligand-Induced Regulation and Localization of Cannabinoid CB1 and Dopamine D2L Receptor Heterodimers
- (2009) J. A. Przybyla et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Calcium Signaling by Dopamine D5 Receptor and D5-D2 Receptor Hetero-Oligomers Occurs by a Mechanism Distinct from That for Dopamine D1-D2 Receptor Hetero-Oligomers
- (2009) C. H. So et al. MOLECULAR PHARMACOLOGY
- Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation
- (2009) Yang Han et al. Nature Chemical Biology
- Pimavanserin, a Serotonin2A Receptor Inverse Agonist, for the Treatment of Parkinson's Disease Psychosis
- (2009) Herbert Y Meltzer et al. NEUROPSYCHOPHARMACOLOGY
- The pharmacology of sigma-1 receptors
- (2009) Tangui Maurice et al. PHARMACOLOGY & THERAPEUTICS
- The discovery of central monoamine neurons gave volume transmission to the wired brain
- (2009) Kjell Fuxe et al. PROGRESS IN NEUROBIOLOGY
- The basal ganglia—from neuronal systems to molecular networks
- (2008) K. Fuxe et al. BRAIN RESEARCH REVIEWS
- Receptor–receptor interactions within receptor mosaics. Impact on neuropsychopharmacology
- (2008) K. Fuxe et al. BRAIN RESEARCH REVIEWS
- Dopamine D2 receptors form higher order oligomers at physiological expression levels
- (2008) Wen Guo et al. EMBO JOURNAL
- Decrease of D2receptor binding but increase in D2-stimulated G-protein activation, dopamine transporter binding and behavioural sensitization in brains of mice treated with a chronic escalating dose ‘binge’ cocaine administration paradigm
- (2008) A. Bailey et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Seven Transmembrane Receptors as Nature's Prototype Allosteric Protein: De-emphasizing the Geography of Binding
- (2008) T. P. Kenakin MOLECULAR PHARMACOLOGY
- Oxytocin as a natural antipsychotic: a study using oxytocin knockout mice
- (2008) H K Caldwell et al. MOLECULAR PSYCHIATRY
- FGF acts as a co-transmitter through adenosine A2A receptor to regulate synaptic plasticity
- (2008) Marc Flajolet et al. NATURE NEUROSCIENCE
- Phenotypic analysis of GalR2 knockout mice in anxiety- and depression-related behavioral tests
- (2008) Xiaoying Lu et al. NEUROPEPTIDES
- Persistent Alterations in Cognitive Function and Prefrontal Dopamine D2 Receptors Following Extended, but Not Limited, Access to Self-Administered Cocaine
- (2008) Lisa A Briand et al. NEUROPSYCHOPHARMACOLOGY
- Heterodimers and Receptor Mosaics of Different Types of G-Protein-Coupled Receptors
- (2008) Kjell Fuxe et al. PHYSIOLOGY
- Neurotensin receptors as modulators of glutamatergic transmission
- (2007) Luca Ferraro et al. BRAIN RESEARCH REVIEWS
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now