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Title
Structure-guided development of heterodimer-selective GPCR ligands
Authors
Keywords
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Journal
Nature Communications
Volume 7, Issue -, Pages 12298
Publisher
Springer Nature
Online
2016-07-26
DOI
10.1038/ncomms12298
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- (2014) Pascal Egloff et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2013) Robert J. Lefkowitz ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
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- (2013) Dasiel O. Borroto-Escuela et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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- (2013) Jianyun Huang et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
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- (2012) Jim F. White et al. NATURE
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- (2012) Brian K. Shoichet et al. TRENDS IN PHARMACOLOGICAL SCIENCES
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- (2009) Yang Han et al. Nature Chemical Biology
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