Basimglurant for treatment of major depressive disorder: a novel negative allosteric modulator of metabotropic glutamate receptor 5

Evidence for the existence of FGFR1–5-HT1A heteroreceptor complexes in the midbrain raphe 5-HT system

(2015) Dasiel O. Borroto-Escuela et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Antidepressant actions of ketamine: from molecular mechanisms to clinical practice

(2015) Lisa M Monteggia et al.   CURRENT OPINION IN NEUROBIOLOGY

Metabotropic glutamate receptor 5 as drug target for Fragile X syndrome

(2015) Sebastian H Scharf et al.   CURRENT OPINION IN PHARMACOLOGY

Metabotropic glutamate receptors as drug targets: what's new?

(2015) Ferdinando Nicoletti et al.   CURRENT OPINION IN PHARMACOLOGY

Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators: Discovery of 2-Chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (Basimglurant, RO4917523), a Promising Novel Medicine for Psychiatric Diseases

(2015) Georg Jaeschke et al.   JOURNAL OF MEDICINAL CHEMISTRY

An excitatory synapse hypothesis of depression

(2015) Scott M. Thompson et al.   TRENDS IN NEUROSCIENCES

Mavoglurant as a treatment for Parkinson’s disease

(2014) Dmitry Petrov et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Dopamine heteroreceptor complexes as therapeutic targets in Parkinson’s disease

(2014) Kjell Fuxe et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

G-protein-coupled receptor type A heteromers as an emerging therapeutic target

(2014) Diego Guidolin et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

The G Protein-Coupled Receptor Heterodimer Network (GPCR-HetNet) and Its Hub Components

(2014) Dasiel Borroto-Escuela et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain

(2014) Andrew S. Doré et al.   NATURE

A Whole-Brain Atlas of Inputs to Serotonergic Neurons of the Dorsal and Median Raphe Nuclei

(2014) Iskra Pollak Dorocic et al.   NEURON

Mice Lacking NMDA Receptors in Parvalbumin Neurons Display Normal Depression-Related Behavior and Response to Antidepressant Action of NMDAR Antagonists

(2014) Laura Pozzi et al.   PLoS One

On the role of adenosine (A)2A receptors in cocaine-induced reward: a pharmacological and neurochemical analysis in rats

(2014) Karolina Wydra et al.   PSYCHOPHARMACOLOGY

Rapid-Acting Glutamatergic Antidepressants: The Path to Ketamine and Beyond

(2013) John H. Krystal et al.   BIOLOGICAL PSYCHIATRY

Neurotransmitter Targeting in the Treatment of Depression

(2013) Pierre Blier   JOURNAL OF CLINICAL PSYCHIATRY

Differential regulation of CaMKIIα interactions with mGluR5 and NMDA receptors by Ca2+in neurons

(2013) Dao-Zhong Jin et al.   JOURNAL OF NEUROCHEMISTRY

Acute Suppression of Spontaneous Neurotransmission Drives Synaptic Potentiation

(2013) E. Nosyreva et al.   JOURNAL OF NEUROSCIENCE

mTOR complexes in neurodevelopmental and neuropsychiatric disorders

(2013) Mauro Costa-Mattioli et al.   NATURE NEUROSCIENCE

Development of allosteric modulators of GPCRs for treatment of CNS disorders

(2013) Hilary Highfield Nickols et al.   NEUROBIOLOGY OF DISEASE

Moonlighting Proteins and Protein–Protein Interactions as Neurotherapeutic Targets in the G Protein-Coupled Receptor Field

(2013) Kjell Fuxe et al.   NEUROPSYCHOPHARMACOLOGY

Monoamine neurocircuitry in depression and strategies for new treatments

(2013) Michel Hamon et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

mGlu5R promotes glutamate AMPA receptor phosphorylation via activation of PKA/DARPP-32 signaling in striatopallidal medium spiny neurons

(2012) Maria Teresa Dell’Anno et al.   NEUROPHARMACOLOGY

mGlu2/3 and mGlu5 receptors: Potential targets for novel antidepressants

(2012) Shigeyuki Chaki et al.   NEUROPHARMACOLOGY

Metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine produces antidepressant effects in rats: Role of brain-derived neurotrophic factor

(2012) C.Y. Liu et al.   NEUROSCIENCE

Synaptic Dysfunction in Depression: Potential Therapeutic Targets

(2012) R. S. Duman et al.   SCIENCE

Distribution of Extrasynaptic NMDA Receptors on Neurons

(2012) Ronald S. Petralia   TheScientificWorldJOURNAL

Extrasynaptic Neurotransmission in the Modulation of Brain Function. Focus on the Striatal Neuronal–Glial Networks

(2012) Kjell Fuxe et al.   Frontiers in Physiology

Reduced Metabotropic Glutamate Receptor 5 Density in Major Depression Determined by [11C]ABP688 PET and Postmortem Study

(2011) Alexandra Deschwanden et al.   AMERICAN JOURNAL OF PSYCHIATRY

The effects of the mGluR5 receptor antagonist 6-methyl-2-(phenylethynyl)-pyridine (MPEP) on the stimulation of dopamine release evoked by nicotine in the rat brain

(2011) Valeria Tronci et al.   BEHAVIOURAL BRAIN RESEARCH

Fibroblast Growth Factor Receptor 1– 5-Hydroxytryptamine 1A Heteroreceptor Complexes and Their Enhancement of Hippocampal Plasticity

(2011) Dasiel O. Borroto-Escuela et al.   BIOLOGICAL PSYCHIATRY

NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses

(2011) Anita E. Autry et al.   NATURE

Towards a glutamate hypothesis of depression

(2011) Gerard Sanacora et al.   NEUROPHARMACOLOGY

A Randomized Add-on Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Bipolar Depression

(2010) Nancy Diazgranados et al.   ARCHIVES OF GENERAL PSYCHIATRY

Galanin receptor-1 modulates 5-hydroxtryptamine-1A signaling via heterodimerization

(2010) Dasiel O. Borroto-Escuela et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Metabotropic Glutamate Receptors as Therapeutic Targets for Cognitive Disorders

(2010) A. Gravius et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Functional interaction of metabotropic glutamate receptor 5 and NMDA-receptor by a metabotropic glutamate receptor 5 positive allosteric modulator

(2010) Holger Rosenbrock et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Efficacy and Effectiveness of Antidepressants: Current Status of Research

(2010) H. Edmund Pigott et al.   PSYCHOTHERAPY AND PSYCHOSOMATICS

Metabotropic glutamate type 5, dopamine D2and adenosine A2areceptors form higher-order oligomers in living cells

(2009) Nuria Cabello et al.   JOURNAL OF NEUROCHEMISTRY

Neuroimaging and Physiological Evidence for Involvement of Glutamatergic Transmission in Regulation of the Striatal Dopaminergic System

(2009) M. Tokunaga et al.   JOURNAL OF NEUROSCIENCE

Allosteric modulation of metabotropic glutamate receptor 5 affects phosphorylation, internalization, and desensitization of the μ-opioid receptor

(2009) H. Schröder et al.   NEUROPHARMACOLOGY

The anxiolytic and analgesic properties of fenobam, a potent mGlu5 receptor antagonist, in relation to the impairment of learning

(2009) Wolfgang Jacob et al.   NEUROPHARMACOLOGY

Role of dopamine receptor mechanisms in the amygdaloid modulation of fear and anxiety: Structural and functional analysis

(2009) Miguel Pérez de la Mora et al.   PROGRESS IN NEUROBIOLOGY

Glutamate-based antidepressants: 20 years on

(2009) Phil Skolnick et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

An Innovative Design to Establish Proof of Concept of the Antidepressant Effects of the NR2B Subunit Selective N-Methyl-D-Aspartate Antagonist, CP-101,606, in Patients With Treatment-Refractory Major Depressive Disorder

(2008) Sheldon H. Preskorn et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Mood disorders: Regulation by metabotropic glutamate receptors

(2007) Andrzej Pilc et al.   BIOCHEMICAL PHARMACOLOGY