Serotonin–glutamate and serotonin–dopamine reciprocal interactions as putative molecular targets for novel antipsychotic treatments: from receptor heterodimers to postsynaptic scaffolding and effector proteins

The Nature of Dopamine Dysfunction in Schizophrenia and What This Means for Treatment

(2012) Oliver D. Howes et al.   ARCHIVES OF GENERAL PSYCHIATRY

A frontier in the understanding of synaptic plasticity: Solving the structure of the postsynaptic density

(2012) Matthew G. Gold   BIOESSAYS

Targeting glutamate system for novel antipsychotic approaches: Relevance for residual psychotic symptoms and treatment resistant schizophrenia

(2012) Andrea de Bartolomeis et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Chronic treatment with lithium or valproate modulates the expression of Homer1b/c and its related genes Shank and Inositol 1,4,5-trisphosphate receptor

(2012) Andrea de Bartolomeis et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Calcium-Dependent Networks in Dopamine–Glutamate Interaction: The Role of Postsynaptic Scaffolding Proteins

(2012) Andrea de Bartolomeis et al.   MOLECULAR NEUROBIOLOGY

Treatment of stroke with a PSD-95 inhibitor in the gyrencephalic primate brain

(2012) Douglas J. Cook et al.   NATURE

Heterocomplex formation of 5-HT2A-mGlu2 and its relevance for cellular signaling cascades

(2012) Hannah K. Delille et al.   NEUROPHARMACOLOGY

Inhibition of glycogen synthase kinase-3 attenuates psychotomimetic effects of ketamine

(2012) Ming-Huan Chan et al.   SCHIZOPHRENIA RESEARCH

Decoding the Signaling of a GPCR Heteromeric Complex Reveals a Unifying Mechanism of Action of Antipsychotic Drugs

(2011) Miguel Fribourg et al.   CELL

Regulation of PI3K/Akt signaling by N-desmethylclozapine through activation of δ-opioid receptor

(2011) Maria C. Olianas et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Effect of clozapine on the dimerization of serotonin 5-HT2A receptor and its genetic variant 5-HT2AH425Y with dopamine D2 receptor

(2011) Sylwia Łukasiewicz et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Serotonin 2A receptor antagonists for treatment of schizophrenia

(2011) Bjørn H Ebdrup et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Evidence for antimanic efficacy of glycogen synthase kinase-3 (GSK3) inhibitors in a strain-specific model of acute mania

(2011) Mikhail Kalinichev et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Regulation of Akt and Wnt signaling by the group II metabotropic glutamate receptor antagonist LY341495 and agonist LY379268

(2011) Laurie P. Sutton et al.   JOURNAL OF NEUROCHEMISTRY

Clozapine functions through the prefrontal cortex serotonin 1A receptor to heighten neuronal activity via calmodulin kinase II-NMDA receptor interactions

(2011) Sudarshana Purkayastha et al.   JOURNAL OF NEUROCHEMISTRY

The Role of 5-Hydroxytryptamine 7 Receptors in the Phencyclidine-Induced Novel Object Recognition Deficit in Rats

(2011) M. Horiguchi et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

An animal model of schizophrenia based on chronic LSD administration: Old idea, new results

(2011) Danuta Marona-Lewicka et al.   NEUROPHARMACOLOGY

Functional crosstalk and heteromerization of serotonin 5-HT2A and dopamine D2 receptors

(2011) Laura Albizu et al.   NEUROPHARMACOLOGY

Group II Metabotropic Glutamate Receptor Agonist Ameliorates MK801-Induced Dysfunction of NMDA Receptors via the Akt/GSK-3β Pathway in Adult Rat Prefrontal Cortex

(2011) Dong Xi et al.   NEUROPSYCHOPHARMACOLOGY

Methylation of the CpG Sites Only on the Sense Strand of the APC Gene Is Specific for Hepatocellular Carcinoma

(2011) Surbhi Jain et al.   PLoS One

Interaction of mGlu2/3 agonism with clozapine and lurasidone to restore novel object recognition in subchronic phencyclidine-treated rats

(2011) Masakuni Horiguchi et al.   PSYCHOPHARMACOLOGY

Density of metabotropic glutamate receptors 2 and 3 (mGluR2/3) in the dorsolateral prefrontal cortex does not differ with schizophrenia diagnosis but decreases with age

(2011) Elisabeth Frank et al.   SCHIZOPHRENIA RESEARCH

Pharmacological characterizations of memantine-induced disruption of prepulse inhibition of the acoustic startle response in mice: Involvement of dopamine D2 and 5-HT2A receptors

(2010) Kota Nakaya et al.   BEHAVIOURAL BRAIN RESEARCH

Dopamine D2 and 5-hydroxytryptamine 5-HT2A receptors assemble into functionally interacting heteromers

(2010) Dasiel O. Borroto-Escuela et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hetero-dimerization of serotonin 5-HT2A and dopamine D2 receptors

(2010) Sylwia Łukasiewicz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

Unraveling Monoamine Receptors Involved in the Action of Typical and Atypical Antipsychotics on Glutamatergic and Serotonergic Transmission in Prefrontal Cortex

(2010) Xavier Lopez-Gil et al.   CURRENT PHARMACEUTICAL DESIGN

Association between AKT1 but not AKTIP genetic variants and increased risk for suicidal behavior in bipolar patients

(2010) L. A. V. Magno et al.   GENES BRAIN AND BEHAVIOR

Abnormalities in α/β-CaMKII and related mechanisms suggest synaptic dysfunction in hippocampus of LPA1 receptor knockout mice

(2010) Laura Musazzi et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Serotonin, But Not N-Methyltryptamines, Activates the Serotonin 2A Receptor Via a  -Arrestin2/Src/Akt Signaling Complex In Vivo

(2010) C. L. Schmid et al.   JOURNAL OF NEUROSCIENCE

Homer-1 polymorphisms are associated with psychopathology and response to treatment in schizophrenic patients

(2010) Ilja Spellmann et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Pattern of acute induction of Homer1a gene is preserved after chronic treatment with first- and second-generation antipsychotics: effect of short-term drug discontinuation and comparison with Homer1a-interacting genes

(2010) Felice Iasevoli et al.   JOURNAL OF PSYCHOPHARMACOLOGY

The administration of psilocybin to healthy, hallucinogen-experienced volunteers in a mock-functional magnetic resonance imaging environment: a preliminary investigation of tolerability

(2010) Robin L Carhart-Harris et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Characterization of the proteome, diseases and evolution of the human postsynaptic density

(2010) Àlex Bayés et al.   NATURE NEUROSCIENCE

The Presynaptic Component of the Serotonergic System is Required for Clozapine's Efficacy

(2010) Prem N Yadav et al.   NEUROPSYCHOPHARMACOLOGY

A cyclic peptide targeted against PSD-95 blocks central sensitization and attenuates thermal hyperalgesia

(2010) B.W. LeBlanc et al.   NEUROSCIENCE

Selective potentiation of the metabotropic glutamate receptor subtype 2 blocks phencyclidine-induced hyperlocomotion and brain activation

(2010) E.A. Hackler et al.   NEUROSCIENCE

Attention deficit induced by blockade of N-methyl d-aspartate receptors in the prefrontal cortex is associated with enhanced glutamate release and cAMP response element binding protein phosphorylation: role of metabotropic glutamate receptors 2/3

(2010) L. Pozzi et al.   NEUROSCIENCE

DRD2/AKT1 interaction on D2 c-AMP independent signaling, attentional processing, and response to olanzapine treatment in schizophrenia

(2010) G. Blasi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The acute and chronic effects of combined antipsychotic–mood stabilizing treatment on the expression of cortical and striatal postsynaptic density genes

(2010) Carmine Tomasetti et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Haloperidol induces higher Homer1a expression than risperidone, olanzapine and sulpiride in striatal sub-regions

(2010) Felice Iasevoli et al.   PSYCHIATRY RESEARCH

Interactive effects of mGlu5 and 5-HT2A receptors on locomotor activity in mice

(2010) Adam L. Halberstadt et al.   PSYCHOPHARMACOLOGY

Effect of tandospirone, a serotonin-1A receptor partial agonist, on information processing and locomotion in dizocilpine-treated rats

(2010) Vera Bubenikova-Valesova et al.   PSYCHOPHARMACOLOGY

Divergent acute and chronic modulation of glutamatergic postsynaptic density genes expression by the antipsychotics haloperidol and sertindole

(2010) Felice Iasevoli et al.   PSYCHOPHARMACOLOGY

Blockade of nucleus accumbens 5-HT2A and 5-HT2C receptors prevents the expression of cocaine-induced behavioral and neurochemical sensitization in rats

(2010) Avi E. Zayara et al.   PSYCHOPHARMACOLOGY

Differential Expression of Metabotropic Glutamate Receptors 2 and 3 in Schizophrenia: A Mechanism for Antipsychotic Drug Action?

(2009) Subroto Ghose et al.   AMERICAN JOURNAL OF PSYCHIATRY

Evaluation of NMDA receptor models of schizophrenia: Divergences in the behavioral effects of sub-chronic PCP and MK-801

(2009) Alexandre Seillier et al.   BEHAVIOURAL BRAIN RESEARCH

Effect of pretreatment with risperidone on phencyclidine-induced disruptions in object recognition memory and prefrontal cortex parvalbumin immunoreactivity in the rat

(2009) Claire E. McKibben et al.   BEHAVIOURAL BRAIN RESEARCH

Role of serotonin-1A receptors in the action of antipsychotic drugs: comparison of prepulse inhibition studies in mice and rats and relevance for human pharmacology

(2009) Andrea Gogos et al.   BEHAVIOURAL PHARMACOLOGY

Antipsychotic and antidepressant co-treatment: Effects on transcripts of inducible postsynaptic density genes possibly implicated in behavioural disorders

(2009) Carmela Dell’Aversano et al.   BRAIN RESEARCH BULLETIN

PSD-95 Is Essential for Hallucinogen and Atypical Antipsychotic Drug Actions at Serotonin Receptors

(2009) A. I. Abbas et al.   JOURNAL OF NEUROSCIENCE

Chronic infusion of PCP via osmotic mini-pumps: A new rodent model of cognitive deficit in schizophrenia characterized by impaired attentional set-shifting (ID/ED) performance

(2009) Christian Spang Pedersen et al.   JOURNAL OF NEUROSCIENCE METHODS

Abnormal prefrontal activation directly related to pre-synaptic striatal dopamine dysfunction in people at clinical high risk for psychosis

(2009) P Fusar-Poli et al.   MOLECULAR PSYCHIATRY

Building a new conceptual framework for receptor heteromers

(2009) Sergi Ferré et al.   Nature Chemical Biology

The 'atypicality' of antipsychotics: a concept re-examined and re-defined

(2009) Gerhard Gründer et al.   NATURE REVIEWS DRUG DISCOVERY

Differential expression of glutamate transporter genes after chronic oral treatment with aripiprazole in rats

(2009) Nina Segnitz et al.   NEUROCHEMISTRY INTERNATIONAL

Treatment with Olanzapine is Associated with Modulation of the Default Mode Network in Patients with Schizophrenia

(2009) Fabio Sambataro et al.   NEUROPSYCHOPHARMACOLOGY

Antipsychotic drug actions on gene modulation and signaling mechanisms

(2009) Raffaella Molteni et al.   PHARMACOLOGY & THERAPEUTICS

Decreased density of serotonin 2A receptors in the superior temporal gyrus in schizophrenia-a postmortem study

(2009) Kai Kang et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Dopamine receptor subtypes contribution to Homer1a induction: Insights into antipsychotic molecular action

(2009) Felice Iasevoli et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Changes in prefrontal and amygdala activity during olanzapine treatment in schizophrenia

(2009) Giuseppe Blasi et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

LSD but not lisuride disrupts prepulse inhibition in rats by activating the 5-HT2A receptor

(2009) Adam L. Halberstadt et al.   PSYCHOPHARMACOLOGY

The Dopamine Hypothesis of Schizophrenia: Version III--The Final Common Pathway

(2009) O. D. Howes et al.   SCHIZOPHRENIA BULLETIN

Dysconnection in Schizophrenia: From Abnormal Synaptic Plasticity to Failures of Self-monitoring

(2009) K. E. Stephan et al.   SCHIZOPHRENIA BULLETIN

Prostate cancer immunotherapy yields superior long-term survival in TRAMP mice when administered at an early stage of carcinogenesis prior to the establishment of tumor-associated immunosuppression at later stages

(2009) Andrew Gray et al.   VACCINE

Molecular biology of 5-HT receptors

(2008) Jason Hannon et al.   BEHAVIOURAL BRAIN RESEARCH

Functional variants of the dopamine receptor D2 gene modulate prefronto-striatal phenotypes in schizophrenia

(2008) Alessandro Bertolino et al.   BRAIN

On the fitting of binding data when receptor dimerization is suspected

(2008) J Giraldo   BRITISH JOURNAL OF PHARMACOLOGY

Identification of a serotonin/glutamate receptor complex implicated in psychosis

(2008) Javier González-Maeso et al.   NATURE

Protein–protein interactions as therapeutic targets in neuropsychopharmacology

(2008) Matthew T Reilly et al.   NEUROPSYCHOPHARMACOLOGY

Striatal D2/D3 Receptor Occupancy, Clinical Response and Side Effects with Amisulpride: An Iodine-123-Iodobenzamide SPET Study

(2008) E. Meisenzahl et al.   PHARMACOPSYCHIATRY

Antagonism of dopamine D2 receptor/ -arrestin 2 interaction is a common property of clinically effective antipsychotics

(2008) B. Masri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of striatal dopamine release by 5-HT2A and 5-HT2C receptor antagonists: [11C]raclopride PET studies in the rat

(2008) Alice Egerton et al.   PSYCHOPHARMACOLOGY

Aripiprazole ameliorates phencyclidine-induced impairment of recognition memory through dopamine D1 and serotonin 5-HT1A receptors

(2008) Taku Nagai et al.   PSYCHOPHARMACOLOGY

Effectiveness of PSD95 Inhibitors in Permanent and Transient Focal Ischemia in the Rat

(2008) Hong-Shuo Sun et al.   STROKE

Comparison between intraperitoneal and subcutaneous phencyclidine administration in Sprague–Dawley rats: A locomotor activity and gene induction study

(2007) Mikhail Kalinichev et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY