Potential Mechanisms Underlying Inflammation-Enhanced Aminoglycoside-Induced Cochleotoxicity

Monitoring neonates for ototoxicity

(2017) Angela C. Garinis et al.   INTERNATIONAL JOURNAL OF AUDIOLOGY

Effect of gentamicin and levels of ambient sound on hearing screening outcomes in the neonatal intensive care unit: A pilot study

(2017) Angela C. Garinis et al.   INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY

The cumulative effects of intravenous antibiotic treatments on hearing in patients with cystic fibrosis

(2017) Angela C. Garinis et al.   Journal of Cystic Fibrosis

N-Arachidonoyl Dopamine Modulates Acute Systemic Inflammation via Nonhematopoietic TRPV1

(2017) Samira K. Lawton et al.   JOURNAL OF IMMUNOLOGY

d-Tubocurarine and Berbamine: Alkaloids That Are Permeant Blockers of the Hair Cell's Mechano-Electrical Transducer Channel and Protect from Aminoglycoside Toxicity

(2017) Nerissa K. Kirkwood et al.   Frontiers in Cellular Neuroscience

Resolution of Cochlear Inflammation: Novel Target for Preventing or Ameliorating Drug-, Noise- and Age-related Hearing Loss

(2017) Gilda M. Kalinec et al.   Frontiers in Cellular Neuroscience

The Contribution of Immune Infiltrates to Ototoxicity and Cochlear Hair Cell Loss

(2017) Megan B. Wood et al.   Frontiers in Cellular Neuroscience

Aminoglycoside-Induced Cochleotoxicity: A Review

(2017) Meiyan Jiang et al.   Frontiers in Cellular Neuroscience

Towards the Prevention of Aminoglycoside-Related Hearing Loss

(2017) Mary E. O’Sullivan et al.   Frontiers in Cellular Neuroscience

Mechanisms of Cisplatin-Induced Ototoxicity and Otoprotection

(2017) Sandeep Sheth et al.   Frontiers in Cellular Neuroscience

Variability in Antibiotic Regimens for Surgical Necrotizing Enterocolitis Highlights the Need for New Guidelines

(2017) Brian P. Blackwood et al.   Surgical Infections

Inhibition of Toll-Like Receptor Signaling as a Promising Therapy for Inflammatory Diseases: A Journey from Molecular to Nano Therapeutics

(2017) Wei Gao et al.   Frontiers in Physiology

Postnatal Innate Immune Development: From Birth to Adulthood

(2017) Anastasia Georgountzou et al.   Frontiers in Immunology

Endothelial STAT3 Activation Increases Vascular Leakage Through Downregulating Tight Junction Proteins: Implications for Diabetic Retinopathy

(2016) Jang-Hyuk Yun et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Fluorescent aminoglycosides reveal intracellular trafficking routes in mechanosensory hair cells

(2016) Dale W. Hailey et al.   JOURNAL OF CLINICAL INVESTIGATION

Interferon (IFN)-Induced Protein 35 (IFI35), a Type I Interferon-Dependent Transcript, Upregulates Inflammatory Signaling Pathways by Activating Toll-Like Receptor 3 in Human Mesangial Cells

(2016) Tadaatsu Imaizumi et al.   KIDNEY & BLOOD PRESSURE RESEARCH

Membrane translocation of TRPC6 channels and endothelial migration are regulated by calmodulin and PI3 kinase activation

(2016) Pinaki Chaudhuri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Mechanism to Explain Ototoxicity in Neonates Exposed to Bumetamide: Lessons to Help Improve Future Product Development in Neonates

(2016) Karel Allegaert et al.   PEDIATRIC DRUGS

Modeling Suggests TRPC3 Hydrogen Bonding and Not Phosphorylation Contributes to the Ataxia Phenotype of the Moonwalker Mouse

(2015) Sonya M. Hanson et al.   BIOCHEMISTRY

Shear stress mediates exocytosis of functional TRPV4 channels in endothelial cells

(2015) Sara Baratchi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mechanisms of Toll-like Receptor 4 Endocytosis Reveal a Common Immune-Evasion Strategy Used by Pathogenic and Commensal Bacteria

(2015) Yunhao Tan et al.   IMMUNITY

Negative regulation of TLR signaling in myeloid cells-implications for autoimmune diseases

(2015) Jessica A. Hamerman et al.   IMMUNOLOGICAL REVIEWS

Effect of sepsis and systemic inflammatory response syndrome on neonatal hearing screening outcomes following gentamicin exposure

(2015) Campbell P. Cross et al.   INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY

High-frequency audiometry reveals high prevalence of aminoglycoside ototoxicity in children with cystic fibrosis

(2015) Ghada Al-Malky et al.   Journal of Cystic Fibrosis

Therapeutic Effects of Treatment with Anti-TLR2 and Anti-TLR4 Monoclonal Antibodies in Polymicrobial Sepsis

(2015) Cristiano Xavier Lima et al.   PLoS One

Localized TRPA1 channel Ca2+signals stimulated by reactive oxygen species promote cerebral artery dilation

(2015) Michelle N. Sullivan et al.   Science Signaling

Endotoxemia-mediated inflammation potentiates aminoglycoside-induced ototoxicity

(2015) Ja-Won Koo et al.   Science Translational Medicine

Local mechanisms for loud sound-enhanced aminoglycoside entry into outer hair cells

(2015) Hongzhe Li et al.   Frontiers in Cellular Neuroscience

Localized TRPA1 channel Ca2+signals stimulated by reactive oxygen species promote cerebral artery dilation

(2015) Michelle N. Sullivan et al.   Science Signaling

Comparing amikacin and kanamycin-induced hearing loss in multidrug-resistant tuberculosis treatment under programmatic conditions in a Namibian retrospective cohort

(2015) Evans L. Sagwa et al.   BMC Pharmacology & Toxicology

Toll-like receptor 3 (TLR3) and the development of type 1 diabetes mellitus

(2015) Taís Silveira Assmann et al.   Archives of Endocrinology Metabolism

Entry of aminoglycosides into renal tubular epithelial cells via endocytosis-dependent and endocytosis-independent pathways

(2014) Junya Nagai et al.   BIOCHEMICAL PHARMACOLOGY

Observation of permeability of blood–labyrinth barrier during cytomegalovirus-induced hearing loss

(2014) Xuanyi Li et al.   INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY

Systemic Lipopolysaccharide Compromises the Blood-Labyrinth Barrier and Increases Entry of Serum Fluorescein into the Perilymph

(2014) Keiko Hirose et al.   JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY

Systemic Lipopolysaccharide Induces Cochlear Inflammation and Exacerbates the Synergistic Ototoxicity of Kanamycin and Furosemide

(2014) Keiko Hirose et al.   JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY

ER-Mitochondrial Calcium Flow Underlies Vulnerability of Mechanosensory Hair Cells to Damage

(2014) R. Esterberg et al.   JOURNAL OF NEUROSCIENCE

Identification and Evaluation of Improved 4'-O-(Alkyl) 4,5-Disubstituted 2-Deoxystreptamines as Next-Generation Aminoglycoside Antibiotics

(2014) S. Duscha et al.   mBio

Inflammatory and immune responses in the cochlea: potential therapeutic targets for sensorineural hearing loss

(2014) Masato Fujioka et al.   Frontiers in Pharmacology

TRPA1: A Transducer and Amplifier of Pain and Inflammation

(2013) Ari Koivisto et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

TNF-α inhibition using etanercept prevents noise-induced hearing loss by improvement of cochlear blood flow in vivo

(2013) Warangkana Arpornchayanon et al.   INTERNATIONAL JOURNAL OF AUDIOLOGY

Sound preconditioning therapy inhibits ototoxic hearing loss in mice

(2013) Soumen Roy et al.   JOURNAL OF CLINICAL INVESTIGATION

Effect of Systemic Lipopolysaccharide-Induced Inflammation on Cytokine Levels in the Murine Cochlea

(2013) Lourdes Quintanilla-Dieck et al.   OTOLARYNGOLOGY-HEAD AND NECK SURGERY

Integrity and Regeneration of Mechanotransduction Machinery Regulate Aminoglycoside Entry and Sensory Cell Death

(2013) Andrew A. Vu et al.   PLoS One

Arachidonic Acid–Induced Dilation in Human Coronary Arterioles: Convergence of Signaling Mechanisms on Endothelial TRPV4‐Mediated Ca 2+ Entry

(2013) Xiaodong Zheng et al.   Journal of the American Heart Association

TRPA1: A Gatekeeper for Inflammation

(2012) Diana M. Bautista et al.   Annual Review of Physiology

TLR4 activation of TRPC6-dependent calcium signaling mediates endotoxin-induced lung vascular permeability and inflammation

(2012) Mohammad Tauseef et al.   JOURNAL OF EXPERIMENTAL MEDICINE

5,6-EET Is Released upon Neuronal Activity and Induces Mechanical Pain Hypersensitivity via TRPA1 on Central Afferent Terminals

(2012) M. Sisignano et al.   JOURNAL OF NEUROSCIENCE

Inner Ear Tissue Remodeling and Ion Homeostasis Gene Alteration in Murine Chronic Otitis Media

(2012) Carol J. MacArthur et al.   OTOLOGY & NEUROTOLOGY

A novel role for interleukin-1 receptor signaling in the developmental regulation of immune responses to endotoxin

(2012) David Martino et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

Bimodal effects of cinnamaldehyde and camphor on mouse TRPA1

(2012) Yeranddy A. Alpizar et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Expression of Transient Receptor Potential Ankyrin 1 (TRPA1) and Its Role in Insulin Release from Rat Pancreatic Beta Cells

(2012) De-Shou Cao et al.   PLoS One

Perivascular-resident macrophage-like melanocytes in the inner ear are essential for the integrity of the intrastrial fluid-blood barrier

(2012) W. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRPC3 and TRPC6 are essential for normal mechanotransduction in subsets of sensory neurons and cochlear hair cells

(2012) K. Quick et al.   Open Biology

LPS-Induced Murine Systemic Inflammation Is Driven by Parenchymal Cell Activation and Exclusively Predicted by Early MCP-1 Plasma Levels

(2011) Justin E. Juskewitch et al.   AMERICAN JOURNAL OF PATHOLOGY

Infection, Inflammation, and Lung Function Decline in Infants with Cystic Fibrosis

(2011) Naveen Pillarisetti et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Infection-Mediated Vasoactive Peptides Modulate Cochlear Uptake of Fluorescent Gentamicin

(2011) Ja-Won Koo et al.   AUDIOLOGY AND NEURO-OTOLOGY

The dilated TRPA1 channel pore state is blocked by amiloride and analogues

(2011) Tue G. Banke   BRAIN RESEARCH

Heteromeric TRPV4-C1 channels contribute to store-operated Ca2+ entry in vascular endothelial cells

(2011) Xin Ma et al.   CELL CALCIUM

TRPA1-Mediated Accumulation of Aminoglycosides in Mouse Cochlear Outer Hair Cells

(2011) Ruben S. Stepanyan et al.   JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY

Mechanotransduction in mouse inner ear hair cells requires transmembrane channel–like genes

(2011) Yoshiyuki Kawashima et al.   JOURNAL OF CLINICAL INVESTIGATION

Acoustic Trauma Increases Cochlear and Hair Cell Uptake of Gentamicin

(2011) Hongzhe Li et al.   PLoS One

Functional Hair Cell Mechanotransducer Channels Are Required for Aminoglycoside Ototoxicity

(2011) Abdelrahman Alharazneh et al.   PLoS One

Short interfering RNA against STAT1 attenuates cisplatin-induced ototoxicity in the rat by suppressing inflammation

(2011) T Kaur et al.   Cell Death & Disease

Systemic aminoglycosides are trafficked via endolymph into cochlear hair cells

(2011) Hongzhe Li et al.   Scientific Reports

Agonist-Induced Changes in Ca2+ Permeation through the Nociceptor Cation Channel TRPA1

(2010) Yuji Karashima et al.   BIOPHYSICAL JOURNAL

Jarisch‐Herxheimer Reaction after Penicillin Therapy among Patients with Syphilis in the Era of the HIV Infection Epidemic: Incidence and Risk Factors

(2010) Chia‐Jui Yang et al.   CLINICAL INFECTIOUS DISEASES

Competitive antagonism of fluorescent gentamicin uptake in the cochlea

(2010) Qi Wang et al.   HEARING RESEARCH

IL-6: from its discovery to clinical applications

(2010) T. Kishimoto   INTERNATIONAL IMMUNOLOGY

The role of caveolae in endothelial cell dysfunction with a focus on nutrition and environmental toxicants

(2010) Zuzana Majkova et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Thermosensitive transient receptor potential channels in human corneal epithelial cells

(2010) Stefan Mergler et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Activation of Lipopolysaccharide-TLR4 Signaling Accelerates the Ototoxic Potential of Cisplatin in Mice

(2010) G.-S. Oh et al.   JOURNAL OF IMMUNOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

TLR4 and Insulin Resistance

(2010) Jane J. Kim et al.   Gastroenterology Research and Practice

TRPV4-mediated endothelial Ca2+ influx and vasodilation in response to shear stress

(2009) Suelhem A. Mendoza et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Cubilin and Megalin Co-Localize in the Neonatal Inner Ear

(2009) Jacob Tauris et al.   AUDIOLOGY AND NEURO-OTOLOGY

The Role of Toll-Like Receptor Pathways in the Mechanism of Type 1 Diabetes

(2009) Egil Lien et al.   CURRENT MOLECULAR MEDICINE

Extracellular divalent cations modulate aminoglycoside-induced hair cell death in the zebrafish lateral line

(2009) Allison B. Coffin et al.   HEARING RESEARCH

Endocytosis and Recycling of Tight Junction Proteins in Inflammation

(2009) Markus Utech et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Pore Dilation Occurs in TRPA1 but Not in TRPM8 Channels

(2009) Jun Chen et al.   Molecular Pain

Zinc activates damage-sensing TRPA1 ion channels

(2009) Hongzhen Hu et al.   Nature Chemical Biology

Nicotine activates the chemosensory cation channel TRPA1

(2009) Karel Talavera et al.   NATURE NEUROSCIENCE

Nociceptive Signals Induce Trafficking of TRPA1 to the Plasma Membrane

(2009) Manuela Schmidt et al.   NEURON

The mechanosensitive cell line ND-C does not express functional thermoTRP channels

(2009) François Rugiero et al.   NEUROPHARMACOLOGY

Prevalence of Mitochondrial 1555A→G Mutation in European Children

(2009) Maria Bitner-Glindzicz et al.   NEW ENGLAND JOURNAL OF MEDICINE

N-Arachidonyl dopamine sensitizes rat capsaicin-sensitive lung vagal afferents via activation of TRPV1 receptors

(2009) Chun-Chun Hsu et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Changes in transient receptor potential vanilloid (TRPV) 1, 2, 3 and 4 expression in mouse inner ear following gentamicin challenge

(2008) Takuya Ishibashi et al.   ACTA OTO-LARYNGOLOGICA

Vanilloid receptor TRPV1-positive sensory afferents in the mouse ankle and knee joints

(2008) Won Gil Cho et al.   BRAIN RESEARCH

Increased capsaicin receptor TRPV1-expressing sensory fibres in irritable bowel syndrome and their correlation with abdominal pain

(2008) A Akbar et al.   GUT

Innate immunity to virus infection

(2008) Osamu Takeuchi et al.   IMMUNOLOGICAL REVIEWS

Toll-Like Receptors, Transduction-Effector Pathways, and Disease Diversity: Evidence of an Immunobiological Paradigm Explaining All Human Illness?

(2008) Timothy J. Atkinson   INTERNATIONAL REVIEWS OF IMMUNOLOGY

TRPV4 enhances the cellular uptake of aminoglycoside antibiotics

(2008) T. Karasawa et al.   JOURNAL OF CELL SCIENCE

Properties of the Inner Pore Region of TRPV1 Channels Revealed by Block with Quaternary Ammoniums

(2008) Andrés Jara-Oseguera et al.   JOURNAL OF GENERAL PHYSIOLOGY

N-((1S)-1- -3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide (GSK1016790A), a Novel and Potent Transient Receptor Potential Vanilloid 4 Channel Agonist Induces Urinary Bladder Contraction and Hyperactivity: Part I

(2008) K. S. Thorneloe et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Acoustic Trauma Augments the Cochlear Immune Response to Antigen

(2008) Masumichi Miyao et al.   LARYNGOSCOPE

Fire in the hole: pore dilation of the capsaicin receptor TRPV1

(2008) Diana Bautista et al.   NATURE NEUROSCIENCE

TRPV1 shows dynamic ionic selectivity during agonist stimulation

(2008) Man-Kyo Chung et al.   NATURE NEUROSCIENCE

Effect of cytokines on neuronal excitability

(2008) Maria Schäfers et al.   NEUROSCIENCE LETTERS

Structure of TRPV1 channel revealed by electron cryomicroscopy

(2008) V. Y. Moiseenkova-Bell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Injury of the Blood Brain Barrier and Up-Regulation of ICAM-1 in Polymicrobial Sepsis

(2007) Stefan Hofer et al.   JOURNAL OF SURGICAL RESEARCH