Journal
ACTA OTO-LARYNGOLOGICA
Volume 129, Issue 2, Pages 116-126Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/00016480802032835
Keywords
TRPV; inner ear; mouse; gentamicin; immunohistochemistry
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Funding
- Japanese Ministry of Health, Labor and Welfare
- Japanese Ministry of Education, Science and Culture [19591972]
- Swedish Medical Research Council [17X-7305]
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Conclusion. It is suggested that transient receptor potential vanilloid (TRPV)-1 and -2 may be of pathological significance for sensory cells and ganglions, while TRPV-3 and -4 may play an important part in neuroprotection of the inner ear. Objective. Changes in the expression of TRPV-1, -2, -3, and -4 in gentamicin (GM)-treated mouse inner ear were studied. Materials and methods. CBA/J mice were used in this study. The localization of TRPV-1, -2, -3, and -4 in the inner ear of both untreated and GM-treated CBA/J animals (intratympanic injection of 5 mg GM) was investigated by immunohistochemistry. Results. TRPV-1, -2, and -3 were co-expressed in the inner ear sensory and ganglion cells, while TRPV-4 was also expressed in the stria vascularis and vestibular dark cells. Following GM treatment, the intensity of immunofluorescent reaction to TRPV-1 and TRPV-2 increased, while that to TRPV-3 and TRPV-4 decreased.
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