d-Tubocurarine and Berbamine: Alkaloids That Are Permeant Blockers of the Hair Cell's Mechano-Electrical Transducer Channel and Protect from Aminoglycoside Toxicity

Protecting Mammalian Hair Cells from Aminoglycoside-Toxicity: Assessing Phenoxybenzamine’s Potential

(2017) Paromita Majumder et al.   Frontiers in Cellular Neuroscience

Is TMC1 the Hair Cell Mechanotransducer Channel?

(2016) Robert Fettiplace   BIOPHYSICAL JOURNAL

Tmc1 Point Mutation Affects Ca2+ Sensitivity and Block by Dihydrostreptomycin of the Mechanoelectrical Transducer Current of Mouse Outer Hair Cells

(2016) L. F. Corns et al.   JOURNAL OF NEUROSCIENCE

Are TMCs the Mechanotransduction Channels of Vertebrate Hair Cells?

(2016) D. P. Corey et al.   JOURNAL OF NEUROSCIENCE

Berbamine inhibited the growth of prostate cancer cells in vivo and in vitro via triggering intrinsic pathway of apoptosis

(2016) Y Zhao et al.   PROSTATE CANCER AND PROSTATIC DISEASES

Natural Bizbenzoquinoline Derivatives Protect Zebrafish Lateral Line Sensory Hair Cells from Aminoglycoside Toxicity

(2016) Matthew Kruger et al.   Frontiers in Cellular Neuroscience

TMC1 and TMC2 Localize at the Site of Mechanotransduction in Mammalian Inner Ear Hair Cell Stereocilia

(2015) Kiyoto Kurima et al.   Cell Reports

Transmembrane channel-like (TMC) genes are required for auditory and vestibular mechanosensation

(2014) Yoshiyuki Kawashima et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Profiling drug-induced cell death pathways in the zebrafish lateral line

(2013) Allison B. Coffin et al.   APOPTOSIS

Bax, Bcl2, and p53 Differentially Regulate Neomycin- and Gentamicin-Induced Hair Cell Death in the Zebrafish Lateral Line

(2013) Allison B. Coffin et al.   JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY

Berbamine Inhibits the Growth of Liver Cancer Cells and Cancer-Initiating Cells by Targeting Ca2+/Calmodulin-Dependent Protein Kinase II

(2013) Z. Meng et al.   MOLECULAR CANCER THERAPEUTICS

TMC1 and TMC2 Are Components of the Mechanotransduction Channel in Hair Cells of the Mammalian Inner Ear

(2013) Bifeng Pan et al.   NEURON

Integrity and Regeneration of Mechanotransduction Machinery Regulate Aminoglycoside Entry and Sensory Cell Death

(2013) Andrew A. Vu et al.   PLoS One

Cisplatin and Aminoglycoside Antibiotics: Hearing Loss and Its Prevention

(2012) Jochen Schacht et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Kinocilia Mediate Mechanosensitivity in Developing Zebrafish Hair Cells

(2012) Katie S. Kindt et al.   DEVELOPMENTAL CELL

Screen of FDA-approved drug library reveals compounds that protect hair cells from aminoglycosides and cisplatin

(2012) Anna L. Vlasits et al.   HEARING RESEARCH

Mechanotransduction in mouse inner ear hair cells requires transmembrane channel–like genes

(2011) Yoshiyuki Kawashima et al.   JOURNAL OF CLINICAL INVESTIGATION

Prestin-Driven Cochlear Amplification Is Not Limited by the Outer Hair Cell Membrane Time Constant

(2011) Stuart L. Johnson et al.   NEURON

Functional Hair Cell Mechanotransducer Channels Are Required for Aminoglycoside Ototoxicity

(2011) Abdelrahman Alharazneh et al.   PLoS One

Natural products and drug discovery. Can thousands of years of ancient medical knowledge lead us to new and powerful drug combinations in the fight against cancer and dementia?

(2009) Hong-Fang Ji et al.   EMBO REPORTS

Response of mechanosensory hair cells of the zebrafish lateral line to aminoglycosides reveals distinct cell death pathways

(2009) Kelly N. Owens et al.   HEARING RESEARCH

Identification of FDA-Approved Drugs and Bioactives that Protect Hair Cells in the Zebrafish (Danio rerio) Lateral Line and Mouse (Mus musculus) Utricle

(2009) Henry C. Ou et al.   JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY

Do we still need the aminoglycosides?

(2008) Emanuele Durante-Mangoni et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Identification of Genetic and Chemical Modulators of Zebrafish Mechanosensory Hair Cell Death

(2008) Kelly N. Owens et al.   PLoS Genetics