Cyclodextrins and Iatrogenic Hearing Loss: New Drugs with Significant Risk

Amphiphilic cyclodextrin nanoparticles

(2017) Gamze Varan et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Intrathecal 2-hydroxypropyl-β-cyclodextrin decreases neurological disease progression in Niemann-Pick disease, type C1: a non-randomised, open-label, phase 1–2 trial

(2017) Daniel S Ory et al.   LANCET

Niemann-Pick disease, type C and Roscoe Brady

(2017) Marc C. Patterson et al.   MOLECULAR GENETICS AND METABOLISM

Early experience with compassionate use of 2 hydroxypropyl-beta-cyclodextrin for Niemann–Pick type C disease: review of initial published cases

(2017) Juan Eduardo Megías-Vericat et al.   NEUROLOGICAL SCIENCES

Aminoglycoside-Induced Cochleotoxicity: A Review

(2017) Meiyan Jiang et al.   Frontiers in Cellular Neuroscience

Characterization of hydroxypropyl-beta-cyclodextrins used in the treatment of Niemann-Pick Disease type C1

(2017) Alfred L. Yergey et al.   PLoS One

Direct administration of 2-Hydroxypropyl-Beta-Cyclodextrin into guinea pig cochleae: Effects on physiological and histological measurements

(2017) J. T. Lichtenhan et al.   PLoS One

Cyclodextrins as Protective Agents of Protein Aggregation: An Overview

(2016) Valentina Oliveri et al.   Chemistry-An Asian Journal

“Back to the Future”: A New Look at Hydroxypropyl Beta-Cyclodextrins

(2016) Milo Malanga et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Scar formation in mice deafened with kanamycin and furosemide

(2016) Magdalena Żak et al.   MICROSCOPY RESEARCH AND TECHNIQUE

Cyclodextrins as Emerging Therapeutic Tools in the Treatment of Cholesterol-Associated Vascular and Neurodegenerative Diseases

(2016) Caroline Coisne et al.   MOLECULES

Fostering collaborative research for rare genetic disease: the example of niemann-pick type C disease

(2016) Steven U. Walkley et al.   Orphanet Journal of Rare Diseases

Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming

(2016) Sebastian Zimmer et al.   Science Translational Medicine

Efficacy and ototoxicity of different cyclodextrins in Niemann-Pick C disease

(2016) Cristin D. Davidson et al.   Annals of Clinical and Translational Neurology

Susceptibility of outer hair cells to cholesterol chelator 2-hydroxypropyl-β-cyclodextrine is prestin-dependent

(2016) Satoe Takahashi et al.   Scientific Reports

Hearing Loss and Otopathology Following Systemic and Intracerebroventricular Delivery of 2-Hydroxypropyl-Beta-Cyclodextrin

(2015) Scott Cronin et al.   JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY

Intrathecal 2-hydroxypropyl-beta-cyclodextrin in a single patient with Niemann–Pick C1

(2015) Timothy J. Maarup et al.   MOLECULAR GENETICS AND METABOLISM

Intracisternal cyclodextrin prevents cerebellar dysfunction and Purkinje cell death in feline Niemann-Pick type C1 disease

(2015) Charles H. Vite et al.   Science Translational Medicine

Molecular regulation of auditory hair cell death and approaches to protect sensory receptor cells and/or stimulate repair following acoustic trauma

(2015) Christine T. Dinh et al.   Frontiers in Cellular Neuroscience

Deletion of Tricellulin Causes Progressive Hearing Loss Associated with Degeneration of Cochlear Hair Cells

(2015) Toru Kamitani et al.   Scientific Reports

Outer Hair Cell Lateral Wall Structure Constrains the Mobility of Plasma Membrane Proteins

(2015) Tetsuji Yamashita et al.   PLoS Genetics

Collaborative Development of 2-Hydroxypropyl-β-Cyclodextrin for the Treatment of Niemann-Pick Type C1 Disease

(2014) Elizabeth Ottinger et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Development and validation of sensitive LC-MS/MS assays for quantification of HP-β-CD in human plasma and CSF

(2014) Hui Jiang et al.   JOURNAL OF LIPID RESEARCH

Fluorescently Labeled Methyl-Beta-Cyclodextrin Enters Intestinal Epithelial Caco-2 Cells by Fluid-Phase Endocytosis

(2014) Ferenc Fenyvesi et al.   PLoS One

Three pools of plasma membrane cholesterol and their relation to cholesterol homeostasis

(2014) Akash Das et al.   eLife

Auditory Phenotype of Niemann-Pick Disease, Type C1

(2013) Kelly A. King et al.   EAR AND HEARING

Involvement of cholesterol depletion from lipid rafts in apoptosis induced by methyl-β-cyclodextrin

(2013) Risako Onodera et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Cyclodextrin alleviates neuronal storage of cholesterol in Niemann-Pick C disease without evidence of detectable blood–brain barrier permeability

(2013) Charles C. Pontikis et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Deafness Induction in Mice

(2013) Thijs T. G. Jansen et al.   OTOLOGY & NEUROTOLOGY

Computational microscopy of cyclodextrin mediated cholesterol extraction from lipid model membranes

(2013) Cesar A. López et al.   Scientific Reports

Neuroprotection by cyclodextrin in cell and mouse models of Alzheimer disease

(2012) Jiaqi Yao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cyclodextrin mediates rapid changes in lipid balance inNpc1−/−mice without carrying cholesterol through the bloodstream

(2012) Anna M. Taylor et al.   JOURNAL OF LIPID RESEARCH

Regulation of presynaptic strength by controlling Ca2+ channel mobility: effects of cholesterol depletion on release at the cone ribbon synapse

(2012) Aaron J. Mercer et al.   JOURNAL OF NEUROPHYSIOLOGY

Effects of cyclodextrin in two patients with Niemann–Pick Type C disease

(2012) Muneaki Matsuo et al.   MOLECULAR GENETICS AND METABOLISM

Hearing Loss and Hair Cell Death in Mice Given the Cholesterol-Chelating Agent Hydroxypropyl-β-Cyclodextrin

(2012) Mark A. Crumling et al.   PLoS One

Evaluation of cholesterol depletion as a marker of nephrotoxicity in vitro for novel β-cyclodextrin derivatives

(2011) Hui Wang et al.   FOOD AND CHEMICAL TOXICOLOGY

Cholesterol Influences Voltage-Gated Calcium Channels and BK-Type Potassium Channels in Auditory Hair Cells

(2011) Erin K. Purcell et al.   PLoS One

Molecular Mechanism of Cyclodextrin Mediated Cholesterol Extraction

(2011) Cesar A. López et al.   PLoS Computational Biology

Evaluation of the cytotoxicity of β-cyclodextrin derivatives: Evidence for the role of cholesterol extraction

(2010) T. Kiss et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Methyl-beta-cyclodextrin induces mitochondrial cholesterol depletion and alters the mitochondrial structure and bioenergetics

(2010) Wieslaw Ziolkowski et al.   FEBS LETTERS

Niemann-Pick disease type C

(2010) Marie T Vanier   Orphanet Journal of Rare Diseases

2-Hydroxypropyl-β-Cyclodextrin Raises Hearing Threshold in Normal Cats and in Cats With Niemann-Pick Type C Disease

(2010) Sarah Ward et al.   PEDIATRIC RESEARCH

Endocytosis of beta-cyclodextrins is responsible for cholesterol reduction in Niemann-Pick type C mutant cells

(2010) A. I. Rosenbaum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid Lateral Mobility in Cochlear Outer Hair Cells: Regional Differences and Regulation by Cholesterol

(2009) Louise E. Organ et al.   JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY

Cholesterol modulates ion channels via down-regulation of phosphatidylinositol 4,5-bisphosphate

(2009) Yoon Sun Chun et al.   JOURNAL OF NEUROCHEMISTRY

Deafness and Permanently Reduced Potassium Channel Gene Expression and Function in Hypothyroid Pit1dw Mutants

(2009) M. Mustapha et al.   JOURNAL OF NEUROSCIENCE

GM1-Ganglioside Accumulation at the Mitochondria-Associated ER Membranes Links ER Stress to Ca2+-Dependent Mitochondrial Apoptosis

(2009) Renata Sano et al.   MOLECULAR CELL

Chronic Cyclodextrin Treatment of Murine Niemann-Pick C Disease Ameliorates Neuronal Cholesterol and Glycosphingolipid Storage and Disease Progression

(2009) Cristin D. Davidson et al.   PLoS One

Reversal of defective lysosomal transport in NPC disease ameliorates liver dysfunction and neurodegeneration in the npc1-/- mouse

(2009) B. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PIP2 Is a Necessary Cofactor for Ion Channel Function: How and Why?

(2008) Byung-Chang Suh et al.   Annual Review of Biophysics

KCNQ4 mutations associated with nonsyndromic progressive sensorineural hearing loss

(2008) Liping Nie   Current Opinion in Otolaryngology & Head and Neck Surgery

Cyclodextrins

(2008) Valentino J. Stella et al.   TOXICOLOGIC PATHOLOGY

In vitro toxicity and permeation of cyclodextrins in Calu-3 cells

(2007) Laura Matilainen et al.   JOURNAL OF CONTROLLED RELEASE