Hearing Loss and Otopathology Following Systemic and Intracerebroventricular Delivery of 2-Hydroxypropyl-Beta-Cyclodextrin

Collaborative Development of 2-Hydroxypropyl-β-Cyclodextrin for the Treatment of Niemann-Pick Type C1 Disease

(2014) Elizabeth Ottinger et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Cyclodextrin alleviates neuronal storage of cholesterol in Niemann-Pick C disease without evidence of detectable blood–brain barrier permeability

(2013) Charles C. Pontikis et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Cisplatin and Aminoglycoside Antibiotics: Hearing Loss and Its Prevention

(2012) Jochen Schacht et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Cisplatin-induced nephrotoxicity and targets of nephroprotection: an update

(2012) Neife Aparecida Guinaim dos Santos et al.   ARCHIVES OF TOXICOLOGY

Normalization of Cholesterol Homeostasis by 2-Hydroxypropyl-β-cyclodextrin in Neurons and Glia from Niemann-Pick C1 (NPC1)-deficient Mice

(2012) Kyle B. Peake et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuroprotection by cyclodextrin in cell and mouse models of Alzheimer disease

(2012) Jiaqi Yao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cyclodextrin mediates rapid changes in lipid balance inNpc1−/−mice without carrying cholesterol through the bloodstream

(2012) Anna M. Taylor et al.   JOURNAL OF LIPID RESEARCH

Effects of cyclodextrin in two patients with Niemann–Pick Type C disease

(2012) Muneaki Matsuo et al.   MOLECULAR GENETICS AND METABOLISM

Hearing Loss and Hair Cell Death in Mice Given the Cholesterol-Chelating Agent Hydroxypropyl-β-Cyclodextrin

(2012) Mark A. Crumling et al.   PLoS One

A perspective from magnetic resonance imaging findings of the inner ear: Relationships among cerebrospinal, ocular and inner ear fluids

(2011) Tsutomu Nakashima et al.   AURIS NASUS LARYNX

Experimental Gentamicin Nephrotoxicity and Agents that Modify it: A Mini-Review of Recent Research

(2011) Badreldin H. Ali et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Membrane cholesterol modulates cochlear electromechanics

(2011) William E. Brownell et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Evaluation of the cytotoxicity of β-cyclodextrin derivatives: Evidence for the role of cholesterol extraction

(2010) T. Kiss et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Methyl-beta-cyclodextrin induces mitochondrial cholesterol depletion and alters the mitochondrial structure and bioenergetics

(2010) Wieslaw Ziolkowski et al.   FEBS LETTERS

Cholesterol Inhibits M-type K+Channels via Protein Kinase C-dependent Phosphorylation in Sympathetic Neurons

(2010) Seul-Yi Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

2-Hydroxypropyl-β-Cyclodextrin Raises Hearing Threshold in Normal Cats and in Cats With Niemann-Pick Type C Disease

(2010) Sarah Ward et al.   PEDIATRIC RESEARCH

Weekly Cyclodextrin Administration Normalizes Cholesterol Metabolism in Nearly Every Organ of the Niemann-Pick Type C1 Mouse and Markedly Prolongs Life

(2010) Charina M Ramirez et al.   PEDIATRIC RESEARCH

Endocytosis of beta-cyclodextrins is responsible for cholesterol reduction in Niemann-Pick type C mutant cells

(2010) A. I. Rosenbaum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cholesterol efflux stimulates metalloproteinase-mediated cleavage of occludin and release of extracellular membrane particles containing its C-terminal fragments

(2009) Elizabeth Casas et al.   EXPERIMENTAL CELL RESEARCH

Deafness and Permanently Reduced Potassium Channel Gene Expression and Function in Hypothyroid Pit1dw Mutants

(2009) M. Mustapha et al.   JOURNAL OF NEUROSCIENCE

Chronic Cyclodextrin Treatment of Murine Niemann-Pick C Disease Ameliorates Neuronal Cholesterol and Glycosphingolipid Storage and Disease Progression

(2009) Cristin D. Davidson et al.   PLoS One

Age-related insulin resistance in hypothalamus and peripheral tissues of orexin knockout mice

(2008) H. Tsuneki et al.   DIABETOLOGIA

Using the Zebrafish Lateral Line to Screen for Ototoxicity

(2008) Lynn L. Chiu et al.   JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY

Cochlear Outer Hair Cell Motility

(2008) Jonathan Ashmore   PHYSIOLOGICAL REVIEWS

Dose translation from animal to human studies revisited

(2007) Shannon Reagan-Shaw et al.   FASEB JOURNAL