Sortase-mediated chemical protein synthesis reveals the bidentate binding of bisphosphorylated p62 with K63 diubiquitin

Total Chemical Synthesis and Folding of All-l and All-d Variants of Oncogenic KRas(G12V)

(2017) Adam M. Levinson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tyrosine sulfation modulates activity of tick-derived thrombin inhibitors

(2017) Robert E. Thompson et al.   Nature Chemistry

Total chemical synthesis of SUMO-2-Lys63-linked diubiquitin hybrid chains assisted by removable solubilizing tags

(2017) Somasekhar Bondalapati et al.   Chemical Science

Accessing human selenoproteins through chemical protein synthesis

(2017) L. Dery et al.   Chemical Science

A semisynthetic Atg3 reveals that acetylation promotes Atg3 membrane binding and Atg8 lipidation

(2017) Yi-Tong Li et al.   Nature Communications

Efficient Palladium-Assisted One-Pot Deprotection of (Acetamidomethyl)Cysteine Following Native Chemical Ligation and/or Desulfurization To Expedite Chemical Protein Synthesis

(2016) Suman Kumar Maity et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chemical Synthesis of Phosphorylated Histone H2A at Tyr57 Reveals Insight into the Inhibition Mode of the SAGA Deubiquitinating Module

(2016) Muhammad Jbara et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Elucidation of the Covalent and Tertiary Structures of Biologically Active Ts3 Toxin

(2016) Bobo Dang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Subunit-Specific Labeling of Ubiquitin Chains by Using Sortase: Insights into the Selectivity of Deubiquitinases

(2016) Sean O. Crowe et al.   CHEMBIOCHEM

Synthetic Uncleavable Ubiquitinated Proteins Dissect Proteasome Deubiquitination and Degradation, and Highlight Distinctive Fate of Tetraubiquitin

(2016) Sumeet K. Singh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In Vivo Site-Specific Protein Tagging with Diverse Amines Using an Engineered Sortase Variant

(2016) Jeff E. Glasgow et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

d-Amino Acid Scan of Two Small Proteins

(2016) Mark D. Simon et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Quasi-Racemic X-ray Structures of K27-Linked Ubiquitin Chains Prepared by Total Chemical Synthesis

(2016) Man Pan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Monomer/Oligomer Quasi-Racemic Protein Crystallography

(2016) Shuai Gao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium Mediated Rapid Deprotection of N-Terminal Cysteine under Native Chemical Ligation Conditions for the Efficient Preparation of Synthetically Challenging Proteins

(2016) Muhammad Jbara et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Multiple Strategies Reveal a Bidentate Interaction between the Nipah Virus Attachment and Fusion Glycoproteins

(2016) Jacquelyn A. Stone et al.   JOURNAL OF VIROLOGY

A synthetic molecular system capable of mirror-image genetic replication and transcription

(2016) Zimou Wang et al.   Nature Chemistry

Structural basis for histone H2B deubiquitination by the SAGA DUB module

(2016) M. T. Morgan et al.   SCIENCE

Posttranslational mutagenesis: A chemical strategy for exploring protein side-chain diversity

(2016) T. H. Wright et al.   SCIENCE

Synthesis and activity of a diselenide bond mimetic of the antimicrobial protein caenopore-5

(2016) Karima Medini et al.   Chemical Science

Accelerating chemoselective peptide bond formation using bis(2-selenylethyl)amido peptide selenoester surrogates

(2016) Laurent Raibaut et al.   Chemical Science

Total chemical synthesis of photoactivatable proteins for light-controlled manipulation of antigen–antibody interactions

(2016) Shan Tang et al.   Chemical Science

An Efficient One-Pot Four-Segment Condensation Method for Protein Chemical Synthesis

(2015) Shan Tang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

p62/SQSTM1 functions as a signaling hub and an autophagy adaptor

(2015) Yoshinori Katsuragi et al.   FEBS Journal

Efficient genetic encoding of phosphoserine and its nonhydrolyzable analog

(2015) Daniel T Rogerson et al.   Nature Chemical Biology

Total synthesis and biochemical characterization of mirror image barnase

(2015) Alexander A. Vinogradov et al.   Chemical Science

The Selective Autophagy Receptor p62 Forms a Flexible Filamentous Helical Scaffold

(2015) Rodolfo Ciuffa et al.   Cell Reports

Proteotoxic Stress Induces Phosphorylation of p62/SQSTM1 by ULK1 to Regulate Selective Autophagic Clearance of Protein Aggregates

(2015) Junghyun Lim et al.   PLoS Genetics

Flow-Based Enzymatic Ligation by Sortase A

(2014) Rocco L. Policarpo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Peptideo-Aminoanilides as Crypto-Thioesters for Protein Chemical Synthesis

(2014) Jia-Xing Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Chemical Synthesis of the Enzyme Sortase AΔN59with Full Catalytic Activity

(2014) Fang-Kun Deng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Irreversible Site-Specific Hydrazinolysis of Proteins by Use of Sortase

(2014) Yi-Ming Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis

(2014) T. Wauer et al.   EMBO JOURNAL

Semienzymatic Cyclization of Disulfide-rich Peptides Using Sortase A

(2014) Xinying Jia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nonenzymatic Polyubiquitination of Expressed Proteins

(2014) Hosahalli P. Hemantha et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Expedient Total Synthesis of Small to Medium-Sized Membrane Proteins via Fmoc Chemistry

(2014) Ji-Shen Zheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cargo recognition and trafficking in selective autophagy

(2014) Alexandra Stolz et al.   NATURE CELL BIOLOGY

Probing the Recognition of Post-Translational Modifications by Combining Sortase-Mediated Ligation and Phage-Assisted Selection

(2013) Till Teschke et al.   ACS Chemical Biology

Synthesis of Autophagosomal Marker Protein LC3-II under Detergent-Free Conditions

(2013) Yi-Chao Huang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Convergent Chemical Synthesis of Histone H2B Protein for the Site-Specific Ubiquitination at Lys34

(2013) Peter Siman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chemical synthesis of proteins using peptide hydrazides as thioester surrogates

(2013) Ji-Shen Zheng et al.   Nature Protocols

Chemoselective sulfenylation and peptide ligation at tryptophan

(2013) Lara R. Malins et al.   Chemical Science

Convergent Chemical Synthesis of Proteins by Ligation of Peptide Hydrazides

(2012) Ge-Min Fang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

PP6 Regulatory Subunit R1 Is Bidentate Anchor for Targeting Protein Phosphatase-6 to DNA-dependent Protein Kinase

(2012) Amol S. Hosing et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Thioester Synthesis Enabled by Sortase

(2012) Jingjing J. Ling et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

p62/SQSTM1/A170: Physiology and pathology

(2012) Masaaki Komatsu et al.   PHARMACOLOGICAL RESEARCH

Preparation of unnatural N-to-N and C-to-C protein fusions

(2012) Martin D. Witte et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein Chemical Synthesis by Ligation of Peptide Hydrazides

(2011) Ge-Min Fang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Selective autophagy mediated by autophagic adapter proteins

(2011) Terje Johansen et al.   Autophagy

Sortase A-catalyzed peptide cyclization for the synthesis of macrocyclic peptides and glycopeptides

(2011) Zhimeng Wu et al.   CHEMICAL COMMUNICATIONS

Crystal Structure of the Ubiquitin-associated (UBA) Domain of p62 and Its Interaction with Ubiquitin

(2011) Shin Isogai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Directed Evolution of Sortase A Mutants with Altered Substrate Selectivity Profiles

(2011) Kirill Piotukh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Serine 403 Phosphorylation of p62/SQSTM1 Regulates Selective Autophagic Clearance of Ubiquitinated Proteins

(2011) Gen Matsumoto et al.   MOLECULAR CELL

Histone H2B ubiquitylation disrupts local and higher-order chromatin compaction

(2011) Beat Fierz et al.   Nature Chemical Biology

Autophagy Suppresses Tumorigenesis through Elimination of p62

(2009) Robin Mathew et al.   CELL

Evidence for Bidentate Substrate Binding as the Basis for the K48 Linkage Specificity of Otubain 1

(2009) Tao Wang et al.   JOURNAL OF MOLECULAR BIOLOGY

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE