Total chemical synthesis of SUMO-2-Lys63-linked diubiquitin hybrid chains assisted by removable solubilizing tags

A Central Cysteine Residue Is Essential for the Thermal Stability and Function of SUMO-1 Protein and SUMO-1 Peptide–Protein Conjugates

(2016) Hervé Drobecq et al.   BIOCONJUGATE CHEMISTRY

Robust Chemical Synthesis of Membrane Proteins through a General Method of Removable Backbone Modification

(2016) Ji-Shen Zheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthetic Uncleavable Ubiquitinated Proteins Dissect Proteasome Deubiquitination and Degradation, and Highlight Distinctive Fate of Tetraubiquitin

(2016) Sumeet K. Singh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Helping Hand to Overcome Solubility Challenges in Chemical Protein Synthesis

(2016) Michael T. Jacobsen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium Mediated Rapid Deprotection of N-Terminal Cysteine under Native Chemical Ligation Conditions for the Efficient Preparation of Synthetically Challenging Proteins

(2016) Muhammad Jbara et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Expanding the chemical toolbox for the synthesis of large and uniquely modified proteins

(2016) Somasekhar Bondalapati et al.   Nature Chemistry

USP7 is a SUMO deubiquitinase essential for DNA replication

(2016) Emilio Lecona et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Palladium-Assisted Removal of a Solubilizing Tag from a Cys Side Chain To Facilitate Peptide and Protein Synthesis

(2016) Suman Kumar Maity et al.   ORGANIC LETTERS

Structural basis for histone H2B deubiquitination by the SAGA DUB module

(2016) M. T. Morgan et al.   SCIENCE

Total chemical synthesis of SUMO proteins

(2016) Oleg Melnyk et al.   TETRAHEDRON LETTERS

USP7 is a SUMO deubiquitinase essential for DNA replication

(2016) Emilio Lecona et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Convergent Versus Sequential Protein Synthesis: The Case of Ubiquitinated and Glycosylated H2B

(2015) Mallikanti Seenaiah et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Peptideo-Aminoanilides as Crypto-Thioesters for Protein Chemical Synthesis

(2014) Jia-Xing Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Traceless Preparation of C-Terminal α-Ketoacids for Chemical Protein Synthesis by α-Ketoacid-Hydroxylamine Ligation: Synthesis of SUMO2/3

(2014) Thomas G. Wucherpfennig et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Formation and Rearrangement of Homoserine Depsipeptides and Depsiproteins in the α-Ketoacid-Hydroxylamine Ligation with 5-Oxaproline

(2014) Thomas G. Wucherpfennig et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nonenzymatic Polyubiquitination of Expressed Proteins

(2014) Hosahalli P. Hemantha et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ube2W conjugates ubiquitin to α-amino groups of protein N-termini

(2013) Michael H. Tatham et al.   BIOCHEMICAL JOURNAL

SUMO-targeted ubiquitin ligases

(2013) Annie M. Sriramachandran et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Synthetic polyubiquitinated  -Synuclein reveals important insights into the roles of the ubiquitin chain in regulating its pathophysiology

(2013) M. Haj-Yahya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Highly efficient one-pot ligation and desulfurization

(2013) Tal Moyal et al.   Chemical Science

Rapid formal hydrolysis of peptide-αthioesters

(2012) Zachary P. Gates et al.   CHEMICAL COMMUNICATIONS

RNF4-Dependent Hybrid SUMO-Ubiquitin Chains Are Signals for RAP80 and Thereby Mediate the Recruitment of BRCA1 to Sites of DNA Damage

(2012) C. M. Guzzo et al.   Science Signaling

Total Chemical Synthesis of a 304 Amino Acid K48-Linked Tetraubiquitin Protein

(2011) K. S. Ajish Kumar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Expanded Click Conjugation of Recombinant Proteins with Ubiquitin-Like Modifiers Reveals Altered Substrate Preference of SUMO2-Modified Ubc9

(2011) Stefanie Sommer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Chemical Synthesis of Di-ubiquitin Chains

(2010) K. S. Ajish Kumar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mechanisms, regulation and consequences of protein SUMOylation

(2010) Kevin A. Wilkinson et al.   BIOCHEMICAL JOURNAL

N-Methylcysteine-mediated total chemical synthesis of ubiquitin thioester

(2010) Lesly A. Erlich et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Linkage-Specific Avidity Defines the Lysine 63-Linked Polyubiquitin-Binding Preference of Rap80

(2009) Joshua J. Sims et al.   MOLECULAR CELL

An Efficient Fmoc-SPPS Approach for the Generation of Thioester Peptide Precursors for Use in Native Chemical Ligation

(2008) Juan B. Blanco-Canosa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chemical synthesis and semisynthesis of membrane proteins

(2008) Diana Olschewski et al.   Molecular BioSystems

RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation

(2008) Michael H. Tatham et al.   NATURE CELL BIOLOGY