A novel RNA-based adjuvant combines strong immunostimulatory capacities with a favorable safety profile

CpG ODN Nanorings Induce IFN  from Plasmacytoid Dendritic Cells and Demonstrate Potent Vaccine Adjuvant Activity

(2014) B. Gungor et al.   Science Translational Medicine

Phase 2 trial of erlotinib with or without PF-3512676 (CPG 7909, a Toll-like receptor 9 agonist) in patients with advanced recurrent EGFR-positive non-small cell lung cancer

(2013) Chandra P Belani et al.   CANCER BIOLOGY & THERAPY

Adjuvants That Improve the Ratio of Antigen-Specific Effector to Regulatory T Cells Enhance Tumor Immunity

(2013) R. Perret et al.   CANCER RESEARCH

Phase Ib trial of the Toll-like receptor 9 agonist IMO-2055 in combination with 5-fluorouracil, cisplatin, and cetuximab as first-line palliative treatment in patients with recurrent/metastatic squamous cell carcinoma of the head and neck

(2013) Jean-Pascal Machiels et al.   INVESTIGATIONAL NEW DRUGS

HPV16 synthetic long peptide (HPV16-SLP) vaccination therapy of patients with advanced or recurrent HPV16-induced gynecological carcinoma, a phase II trial

(2013) Mariette I E van Poelgeest et al.   Journal of Translational Medicine

Critical Role of an Antiviral Stress Granule Containing RIG-I and PKR in Viral Detection and Innate Immunity

(2012) Koji Onomoto et al.   PLoS One

Trial Watch

(2012) Lorenzo Galluzzi et al.   OncoImmunology

Trial watch: FDA-approved Toll-like receptor agonists for cancer therapy

(2012) Erika Vacchelli et al.   OncoImmunology

Regulation of effector and memory T-cell functions by type I interferon

(2011) Jonathan P. Huber et al.   IMMUNOLOGY

Synthetic double-stranded RNA induces innate immune responses similar to a live viral vaccine in humans

(2011) Marina Caskey et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IFN-α produced by human plasmacytoid dendritic cells enhances T cell-dependent naïve B cell differentiation

(2011) Cornelia Gujer et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Phase I clinical trial of CpG oligonucleotide 7909 (PF-03512676) in patients with previously treated chronic lymphocytic leukemia

(2011) Clive S. Zent et al.   LEUKEMIA & LYMPHOMA

Programming the magnitude and persistence of antibody responses with innate immunity

(2011) Sudhir Pai Kasturi et al.   NATURE

Efficient induction of anti-tumor immunity by a TAT-CEA fusion protein vaccine with poly(I:C) in a murine colorectal tumor model

(2011) Jung-Sun Park et al.   VACCINE

Pitfalls of vaccinations with WT1-, Proteinase3- and MUC1-derived peptides in combination with MontanideISA51 and CpG7909

(2010) Jürgen Kuball et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Toll-like Receptor 3–Mediated Suppression of TRAMP Prostate Cancer Shows the Critical Role of Type I Interferons in Tumor Immune Surveillance

(2010) Arnold I. Chin et al.   CANCER RESEARCH

Effects of IFN-α as a signal-3 cytokine on human naïve and antigen-experienced CD8+ T cells

(2010) Sandra Hervas-Stubbs et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Combination adjuvants: the next generation of adjuvants?

(2010) George Mutwiri et al.   Expert Review of Vaccines

Regulation of inflammasome activity

(2010) Greta Guarda et al.   IMMUNOLOGY

Intranasal administration of adjuvant-combined vaccine protects monkeys from challenge with the highly pathogenic influenza A H5N1 virus

(2010) Takeshi Ichinohe et al.   JOURNAL OF MEDICAL VIROLOGY

Caspase 1–independent activation of interleukin-1β in neutrophil-predominant inflammation

(2009) Monica Guma et al.   ARTHRITIS AND RHEUMATISM

Inflammatory arthritis in caspase 1 gene–deficient mice: Contribution of proteinase 3 to caspase 1–independent production of bioactive interleukin-1β

(2009) Leo A. B. Joosten et al.   ARTHRITIS AND RHEUMATISM

Induction of Tumor-Specific CD4+ and CD8+ T-Cell Immunity in Cervical Cancer Patients by a Human Papillomavirus Type 16 E6 and E7 Long Peptides Vaccine

(2008) M. J.P. Welters et al.   CLINICAL CANCER RESEARCH

Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans

(2008) Troy D Querec et al.   NATURE IMMUNOLOGY

Molecular and cellular signatures of human vaccine adjuvants

(2008) F. Mosca et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA