Eradication of HIV-1 from the Macrophage Reservoir: An Uncertain Goal?

Healthy HIV-1-Infected Individuals on Highly Active Antiretroviral Therapy Harbor HIV-1 in Their Alveolar Macrophages

(2015) Sushma K. Cribbs et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Progress Towards an HIV Cure: Update from the 2014 International AIDS Society Symposium

(2015) Jenny Louise Anderson et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Cyclin L2 Is a Critical HIV Dependency Factor in Macrophages that Controls SAMHD1 Abundance

(2015) George Boateng Kyei et al.   Cell Host & Microbe

Endogenous CCL2 neutralization restricts HIV-1 replication in primary human macrophages by inhibiting viral DNA accumulation

(2015) Michela Sabbatucci et al.   Retrovirology

Changes in HIV reservoirs during long-term antiretroviral therapy

(2015) Feiyu F. Hong et al.   Current Opinion in HIV and AIDS

How does the timing of antiretroviral therapy initiation in acute infection affect HIV reservoirs?

(2015) Jintanat Ananworanich et al.   Current Opinion in HIV and AIDS

Efficient transfer of HIV-1 in trans and in cis from Langerhans dendritic cells and macrophages to autologous T lymphocytes

(2014) Maryse Peressin et al.   AIDS

The importance of monocytes and macrophages in HIV pathogenesis, treatment, and cure

(2014) Jennifer H. Campbell et al.   AIDS

HIV-1 reprograms the migration of macrophages

(2014) C. Verollet et al.   BLOOD

Macrophage Infection via Selective Capture of HIV-1-Infected CD4+ T Cells

(2014) Amy E. Baxter et al.   Cell Host & Microbe

Mononuclear Phagocyte Accumulation in Visceral Tissue in HIV Encephalitis: Evidence for Increased Monocyte/Macrophage Trafficking and Altered Differentiation

(2014) Tracy Fischer et al.   CURRENT HIV RESEARCH

Brain Inflammation is a Common Feature of HIV-Infected Patients without HIV Encephalitis or Productive Brain Infection

(2014) Eleonora Tavazzi et al.   CURRENT HIV RESEARCH

Macrophages, Immunity, and Metabolic Disease

(2014) Joanne C. McNelis et al.   IMMUNITY

M-CSF Inhibits Anti-HIV-1 Activity of IL-32, but They Enhance M2-like Phenotypes of Macrophages

(2014) A. Osman et al.   JOURNAL OF IMMUNOLOGY

M1 and M2 Macrophages: The Chicken and the Egg of Immunity

(2014) Charles D. Mills et al.   Journal of Innate Immunity

The chemotaxis of M1 and M2 macrophages is regulated by different chemokines

(2014) Wenjuan Xuan et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Role of myeloid cells in HIV-1-host interplay

(2014) Mario Stevenson   JOURNAL OF NEUROVIROLOGY

HIV infection: epidemiology, pathogenesis, treatment, and prevention

(2014) Gary Maartens et al.   LANCET

Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013

(2014) Christopher J L Murray et al.   LANCET

Early treatment may not be early enough

(2014) Kai Deng et al.   NATURE

Opening Fronts in HIV Vaccine Development: Targeting reservoirs to clear and cure

(2014) Robert F Siliciano   NATURE MEDICINE

HMGA1 recruits CTIP2-repressed P-TEFb to the HIV-1 and cellular target promoters

(2014) Sebastian Eilebrecht et al.   NUCLEIC ACIDS RESEARCH

Cellular Activation and Intracellular HCV Load in Peripheral Blood Monocytes Isolated from HCV Monoinfected and HIV-HCV Coinfected Patients

(2014) Isabelle Dichamp et al.   PLoS One

Long-lived reservoirs of HIV-1

(2014) Thomas D. Zaikos et al.   TRENDS IN MICROBIOLOGY

HIV cure research: Advances and prospects

(2014) Caroline P. Passaes et al.   VIROLOGY

HIV-1 Latency in Monocytes/Macrophages

(2014) Amit Kumar et al.   Viruses-Basel

HIV-1 Nef Induces CCL5 production in astrocytes through p38-MAPK and PI3K/Akt pathway and utilizes NF-kB, CEBP and AP-1 transcription factors

(2014) Xun Liu et al.   Scientific Reports

CD4 Depletion in SIV-Infected Macaques Results in Macrophage and Microglia Infection with Rapid Turnover of Infected Cells

(2014) Luca Micci et al.   PLoS Pathogens

Understanding HIV Compartments and Reservoirs

(2014) Valentina Svicher et al.   Current HIV/AIDS Reports

How Might We Cure HIV?

(2014) David M. Margolis   Current Infectious Disease Reports

From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation

(2014) Paola Italiani et al.   Frontiers in Immunology

Role of P-Glycoprotein in the Distribution of the HIV Protease Inhibitor Atazanavir in the Brain and Male Genital Tract

(2013) Kevin R. Robillard et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Replication-Competent Noninduced Proviruses in the Latent Reservoir Increase Barrier to HIV-1 Cure

(2013) Ya-Chi Ho et al.   CELL

An Integrated Overview of HIV-1 Latency

(2013) Debbie S. Ruelas et al.   CELL

Macrophages

(2013) Sarah A. Watters et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Emerging strategies to deplete the HIV reservoir

(2013) Nancie M. Archin et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Increased in vitro glial fibrillary acidic protein expression, telomerase activity, and telomere length after productive human immunodeficiency virus-1 infection in murine astrocytes

(2013) Diego Ojeda et al.   JOURNAL OF NEUROSCIENCE RESEARCH

High-Multiplicity HIV-1 Infection and Neutralizing Antibody Evasion Mediated by the Macrophage-T Cell Virological Synapse

(2013) C. J. A. Duncan et al.   JOURNAL OF VIROLOGY

The end of AIDS: HIV infection as a chronic disease

(2013) Steven G Deeks et al.   LANCET

Barriers to a cure for HIV: new ways to target and eradicate HIV-1 reservoirs

(2013) Christine Katlama et al.   LANCET

TNF and TNF Receptor Superfamily Members in HIV infection: New Cellular Targets for Therapy?

(2013) Amit Kumar et al.   MEDIATORS OF INFLAMMATION

Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection

(2013) Caroline Goujon et al.   NATURE

Inhibition of P-Glycoprotein by HIV Protease Inhibitors Increases Intracellular Accumulation of Berberine in Murine and Human Macrophages

(2013) Weibin Zha et al.   PLoS One

CTIP2 is a negative regulator of P-TEFb

(2013) T. Cherrier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p21-mediated RNR2 repression restricts HIV-1 replication in macrophages by inhibiting dNTP biosynthesis pathway

(2013) A. Allouch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV-1 transcription and latency: an update

(2013) Carine Van Lint et al.   Retrovirology

Novel factors interfering with human immunodeficiency virus-type 1 replicationin vivoandin vitro

(2013) E. Vicenzi et al.   TISSUE ANTIGENS

HIV Latency

(2013) R. F. Siliciano et al.   Cold Spring Harbor Perspectives in Medicine

Non-coding RNAs: novel players in chromatin-regulation during viral latency

(2013) Sebastian Eilebrecht et al.   Current Opinion in Virology

Cellular Pharmacology and Potency of HIV-1 Nucleoside Analogs in Primary Human Macrophages

(2012) Christina Gavegnano et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Editorial [Hot Topic: Mechanisms of HIV-1 Latency Post HAART Treatment Area (Guest Editors: Lena Al-Harthi and Fatah Kashanchi)]

(2012) Lena Al-Harthi et al.   CURRENT HIV RESEARCH

Selective Expansion of Pro-inflammatory Chemokine CCL2-Loaded CD14+CD16+ Monocytes Subset in HIV-Infected Therapy Naïve Individuals

(2012) A. Wahid Ansari et al.   JOURNAL OF CLINICAL IMMUNOLOGY

BET bromodomain inhibition as a novel strategy for reactivation of HIV-1

(2012) Camellia Banerjee et al.   JOURNAL OF LEUKOCYTE BIOLOGY

SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates

(2012) Hichem Lahouassa et al.   NATURE IMMUNOLOGY

Macrophages and their relevance in Human Immunodeficiency Virus Type I infection

(2012) Herwig Koppensteiner et al.   Retrovirology

Developing strategies for HIV-1 eradication

(2012) Christine M. Durand et al.   TRENDS IN IMMUNOLOGY

Nicotine vaccines to treat tobacco dependence

(2012) Maciej L. Goniewicz et al.   Human Vaccines & Immunotherapeutics

Single Mutations in HIV Integrase Confer High-Level Resistance to Raltegravir in Primary Human Macrophages

(2011) Matthew D. Marsden et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

CCL2: A potential prognostic marker and target of anti-inflammatory strategy in HIV/AIDS pathogenesis

(2011) Abdul W. Ansari et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Circulating Monocytes Are Not a Major Reservoir of HIV-1 in Elite Suppressors

(2011) A. M. Spivak et al.   JOURNAL OF VIROLOGY

Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein

(2011) Kasia Hrecka et al.   NATURE

HIV-1 Nef Induces Proinflammatory State in Macrophages through Its Acidic Cluster Domain: Involvement of TNF Alpha Receptor Associated Factor 2

(2011) Giorgio Mangino et al.   PLoS One

APOBEC3A Is a Specific Inhibitor of the Early Phases of HIV-1 Infection in Myeloid Cells

(2011) Gregory Berger et al.   PLoS Pathogens

Editorial: Monocyte subpopulations and lentiviral infection

(2010) Suzanne M. Crowe et al.   JOURNAL OF LEUKOCYTE BIOLOGY

HIV DNA in circulating monocytes as a mechanism to dementia and other HIV complications

(2010) Victor G. Valcour et al.   JOURNAL OF LEUKOCYTE BIOLOGY

HIV-1 neuroimmunity in the era of antiretroviral therapy

(2010) Stephanie D. Kraft-Terry et al.   NEUROBIOLOGY OF DISEASE

The macrophage in HIV-1 infection: From activation to deactivation?

(2010) Georges Herbein et al.   Retrovirology

Macrophage signaling in HIV-1 infection

(2010) Georges Herbein et al.   Retrovirology

Molecular mechanisms of HIV-1 persistence in the monocyte-macrophage lineage

(2010) Valentin Le Douce et al.   Retrovirology

Mechanisms of HIV Latency: an Emerging Picture of Complexity

(2010) David M. Margolis   Current HIV/AIDS Reports

Novel approaches to inhibiting HIV-1 replication

(2009) Catherine S. Adamson et al.   ANTIVIRAL RESEARCH

Determination of Hepatitis C Virus–Infected, Monocyte Lineage Reservoirs in Individuals With or Without HIV Coinfection

(2009) Gerald Coquillard et al.   JOURNAL OF INFECTIOUS DISEASES

Macrophage polarization and HIV-1 infection

(2009) Edana Cassol et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Monocyte heterogeneity underlying phenotypic changes in monocytes according to SIV disease stage

(2009) Woong-Ki Kim et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Understanding HIV-1 latency provides clues for the eradication of long-term reservoirs

(2009) Mayte Coiras et al.   NATURE REVIEWS MICROBIOLOGY

Structure of HIV-1 protease in complex with potent inhibitor KNI-272 determined by high-resolution X-ray and neutron crystallography

(2009) M. Adachi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular control of HIV-1 postintegration latency: implications for the development of new therapeutic strategies

(2009) Laurence Colin et al.   Retrovirology

HIV interactions with monocytes and dendritic cells: viral latency and reservoirs

(2009) Christopher M Coleman et al.   Retrovirology

The Challenge of Finding a Cure for HIV Infection

(2009) D. D. Richman et al.   SCIENCE

Cell Biology of HIV-1 Infection of Macrophages

(2008) Carol A. Carter et al.   Annual Review of Microbiology

Telomerase activity of HIV-1-specific CD8+ T cells: constitutive up-regulation in controllers and selective increase by blockade of PD ligand 1 in progressors

(2008) M. Lichterfeld et al.   BLOOD

The Interferon-Induced Protein BST-2 Restricts HIV-1 Release and Is Downregulated from the Cell Surface by the Viral Vpu Protein

(2008) Nanette Van Damme et al.   Cell Host & Microbe

Cellular Reservoirs of HIV-1 and their Role in Viral Persistence

(2008) Aikaterini Alexaki et al.   CURRENT HIV RESEARCH

Blood Monocytes Harbor HIV Type 1 Strains with Diversified Phenotypes Including Macrophage‐Specific CCR5 Virus

(2008) Younong Xu et al.   JOURNAL OF INFECTIOUS DISEASES

Up-regulation of P-glycoprotein by HIV protease inhibitors in a human brain microvessel endothelial cell line

(2008) Jason A. Zastre et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Characterization of the Early Steps of Infection of Primary Blood Monocytes by Human Immunodeficiency Virus Type 1

(2008) V. Arfi et al.   JOURNAL OF VIROLOGY

Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu

(2008) Stuart J. D. Neil et al.   NATURE

Is HIV infection a TNF receptor signalling-driven disease?

(2008) Georges Herbein et al.   TRENDS IN IMMUNOLOGY

Human macrophages support persistent transcription from unintegrated HIV-1 DNA

(2007) Jeremy Kelly et al.   VIROLOGY