Sustained IFN-I Expression during Established Persistent Viral Infection: A “Bad Seed” for Protective Immunity

B-cell responses to HIV infection

(2017) Susan Moir et al.   IMMUNOLOGICAL REVIEWS

HIV-antibody complexes enhance production of type I interferon by plasmacytoid dendritic cells

(2017) Rebecca T. Veenhuis et al.   JOURNAL OF CLINICAL INVESTIGATION

Type I Interferon in Chronic Virus Infection and Cancer

(2017) Laura M. Snell et al.   TRENDS IN IMMUNOLOGY

B-cell abnormalities and impact on antibody response in HIV infection

(2017) Alessandra Noto et al.   Current Opinion in HIV and AIDS

The Significance of Type-I Interferons in the Pathogenesis and Therapy of Human Immunodeficiency Virus 1 Infection

(2017) Bowen Wang et al.   Frontiers in Immunology

Cytokines and persistent viral infections

(2016) Jean-Christophe Beltra et al.   CYTOKINE

Current topics in HIV pathogenesis, part 2: Inflammation drives a Warburg-like effect on the metabolism of HIV-infected subjects

(2016) Mouna Aounallah et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Blocking type I interferon signaling enhances T cell recovery and reduces HIV-1 reservoirs

(2016) Liang Cheng et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting type I interferon–mediated activation restores immune function in chronic HIV infection

(2016) Anjie Zhen et al.   JOURNAL OF CLINICAL INVESTIGATION

Chronic Type I IFN Is Sufficient To Promote Immunosuppression through Accumulation of Myeloid-Derived Suppressor Cells

(2016) Kahina Taleb et al.   JOURNAL OF IMMUNOLOGY

Type I interferons in viral control and immune regulation

(2016) John R Teijaro   Current Opinion in Virology

Type I and Type II Interferon Coordinately Regulate Suppressive Dendritic Cell Fate and Function during Viral Persistence

(2016) Cameron R. Cunningham et al.   PLoS Pathogens

Type I Interferon Impairs Specific Antibody Responses Early during Establishment of LCMV Infection

(2016) Matthieu Daugan et al.   Frontiers in Immunology

Type I IFN – A blunt spear in fighting HIV-1 infection

(2015) Chiara Acchioni et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Immunoactivation induced by chronic viral infection inhibits viral replication and drives immunosuppression through sustained IFN-I responses

(2015) Nadine Honke et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IFN-α-Induced Downregulation of miR-221 in Dendritic Cells: Implications for HCV Pathogenesis and Treatment

(2015) Mohit Sehgal et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Type I Interferon: Understanding Its Role in HIV Pathogenesis and Therapy

(2015) Steven E. Bosinger et al.   Current HIV/AIDS Reports

Molecular and Transcriptional Basis of CD4+ T Cell Dysfunction during Chronic Infection

(2014) Alison Crawford et al.   IMMUNITY

Abnormal B cell memory subsets dominate HIV-specific responses in infected individuals

(2014) Lela Kardava et al.   JOURNAL OF CLINICAL INVESTIGATION

Type I interferons directly inhibit regulatory T cells to allow optimal antiviral T cell responses during acute LCMV infection

(2014) Shivani Srivastava et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection

(2014) Pablo Penaloza-MacMaster et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IFN-α Exerts Opposing Effects on Activation-Induced and IL-7–Induced Proliferation of T Cells That May Impair Homeostatic Maintenance of CD4+T Cell Numbers in Treated HIV Infection

(2014) Lilian Cha et al.   JOURNAL OF IMMUNOLOGY

Regulatory T Cells Resist Virus Infection-Induced Apoptosis

(2014) Jenny W. Che et al.   JOURNAL OF VIROLOGY

Type I interferon responses in rhesus macaques prevent SIV infection and slow disease progression

(2014) Netanya G. Sandler et al.   NATURE

Type I interferon suppresses de novo virus-specific CD4 Th1 immunity during an established persistent viral infection

(2014) I. Osokine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chronic Exposure to Type-I IFN under Lymphopenic Conditions Alters CD4 T Cell Homeostasis

(2014) Cecile Le Saout et al.   PLoS Pathogens

Interfering with type I Interferon: A novel approach to purge persistent viral infection

(2013) Elizabeth Wilson et al.   CELL CYCLE

Pharmacogenomics and Translational Simulations to Bridge Indications for an Anti-Interferon-α Receptor Antibody

(2013) B Wang et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Chronic but Not Acute Virus Infection Induces Sustained Expansion of Myeloid Suppressor Cell Numbers that Inhibit Viral-Specific T Cell Immunity

(2013) Brian A. Norris et al.   IMMUNITY

Insights into B cells and HIV-specific B-cell responses in HIV-infected individuals

(2013) Susan Moir et al.   IMMUNOLOGICAL REVIEWS

Interferon-α Is the Primary Plasma Type-I IFN in HIV-1 Infection and Correlates with Immune Activation and Disease Markers

(2013) Gareth A. D. Hardy et al.   PLoS One

Blockade of Chronic Type I Interferon Signaling to Control Persistent LCMV Infection

(2013) E. B. Wilson et al.   SCIENCE

Persistent LCMV Infection Is Controlled by Blockade of Type I Interferon Signaling

(2013) J. R. Teijaro et al.   SCIENCE

Decoding the complexity of type I interferon to treat persistent viral infections

(2013) Elizabeth B. Wilson et al.   TRENDS IN MICROBIOLOGY

Type I Interferon Upregulates Bak and Contributes to T Cell Loss during Human Immunodeficiency Virus (HIV) Infection

(2013) Joseph A. Fraietta et al.   PLoS Pathogens

Safety and pharmacodynamics of rontalizumab in patients with systemic lupus erythematosus: Results of a phase I, placebo-controlled, double-blind, dose-escalation study

(2012) Jacqueline M. McBride et al.   ARTHRITIS AND RHEUMATISM

Timing and Magnitude of Type I Interferon Responses by Distinct Sensors Impact CD8 T Cell Exhaustion and Chronic Viral Infection

(2012) Yaming Wang et al.   Cell Host & Microbe

HIV-1, interferon and the interferon regulatory factor system: An interplay between induction, antiviral responses and viral evasion

(2012) Giulia Marsili et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Foxo3a: An integrator of immune dysfunction during HIV infection

(2012) Julien van Grevenynghe et al.   CYTOKINE & GROWTH FACTOR REVIEWS

The Blood Transcriptional Signature of Chronic Hepatitis C Virus Is Consistent with an Ongoing Interferon-Mediated Antiviral Response

(2012) Christopher R. Bolen et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Loss of memory B cells during chronic HIV infection is driven by Foxo3a- and TRAIL-mediated apoptosis

(2011) Julien van Grevenynghe et al.   JOURNAL OF CLINICAL INVESTIGATION

Comparative transcriptomics of extreme phenotypes of human HIV-1 infection and SIV infection in sooty mangabey and rhesus macaque

(2011) Margalida Rotger et al.   JOURNAL OF CLINICAL INVESTIGATION

Type I interferon negatively controls plasmacytoid dendritic cell numbers in vivo

(2011) Melissa Swiecki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD4+ T-Cell Deficiency in HIV Patients Responding to Antiretroviral Therapy Is Associated With Increased Expression of Interferon-Stimulated Genes in CD4+ T Cells

(2011) Sonia Fernandez et al.   JOURNAL OF INFECTIOUS DISEASES

B and T Lymphocyte Attenuator Down-regulation by HIV-1 Depends on Type I Interferon and Contributes to T-Cell Hyperactivation

(2011) Zheng Zhang et al.   JOURNAL OF INFECTIOUS DISEASES

Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virus

(2011) Nadine Honke et al.   NATURE IMMUNOLOGY

Interferon-α drives monocyte gene expression in chronic unsuppressed HIV-1 infection

(2010) Hans Rempel et al.   AIDS

Chronic viral hepatitis: epidemiology, molecular biology, and antiviral therapy

(2010) Stevan et al.   Frontiers in Bioscience-Landmark

Downregulation of Robust Acute Type I Interferon Responses Distinguishes Nonpathogenic Simian Immunodeficiency Virus (SIV) Infection of Natural Hosts from Pathogenic SIV Infection of Rhesus Macaques

(2010) L. D. Harris et al.   JOURNAL OF VIROLOGY

Programmed death-1–induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection

(2010) Elias A Said et al.   NATURE MEDICINE

Desensitization to type I interferon in HIV-1 infection correlates with markers of immune activation and disease progression

(2009) G. A. D. Hardy et al.   BLOOD

Increased Interferon Alpha Expression in Circulating Plasmacytoid Dendritic Cells of HIV-1-Infected Patients

(2009) Clara Lehmann et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Nonpathogenic SIV infection of African green monkeys induces a strong but rapidly controlled type I IFN response

(2009) Béatrice Jacquelin et al.   JOURNAL OF CLINICAL INVESTIGATION

PDL-1 upregulation on monocytes and T cells by HIV via type I interferon: Restricted expression of type I interferon receptor by CCR5-expressing leukocytes

(2008) Adriano Boasso et al.   CLINICAL IMMUNOLOGY

Divergent TLR7 and TLR9 signaling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infections

(2008) Judith N Mandl et al.   NATURE MEDICINE

Transcription factor FOXO3a controls the persistence of memory CD4+ T cells during HIV infection

(2008) Julien van Grevenynghe et al.   NATURE MEDICINE

HIV-Induced Type I Interferon and Tryptophan Catabolism Drive T Cell Dysfunction Despite Phenotypic Activation

(2008) Adriano Boasso et al.   PLoS One

Lymph node architecture collapse and consequent modulation of FOXO3a pathway on memory T- and B-cells during HIV infection

(2008) Julien van Grevenynghe et al.   SEMINARS IN IMMUNOLOGY

T-cell exhaustion in HIV infection

(2008) Mohamed El-Far et al.   Current HIV/AIDS Reports

Chronic innate immune activation as a cause of HIV-1 immunopathogenesis

(2007) Adriano Boasso et al.   CLINICAL IMMUNOLOGY