Pharmacogenomics and Translational Simulations to Bridge Indications for an Anti-Interferon-α Receptor Antibody

Use of type I interferon-inducible mRNAs as pharmacodynamic markers and potential diagnostic markers in trials with sifalimumab, an anti-IFNα antibody, in systemic lupus erythematosus

(2012) Yihong Yao et al.   ARTHRITIS RESEARCH & THERAPY

Safety profile and clinical activity of sifalimumab, a fully human anti-interferon   monoclonal antibody, in systemic lupus erythematosus: a phase I, multicentre, double-blind randomised study

(2011) J. T. Merrill et al.   ANNALS OF THE RHEUMATIC DISEASES

Patients with systemic lupus erythematosus, myositis, rheumatoid arthritis and scleroderma share activation of a common type I interferon pathway

(2011) B. W. Higgs et al.   ANNALS OF THE RHEUMATIC DISEASES

Type I interferon system activation and association with disease manifestations in systemic sclerosis

(2010) M.-L. Eloranta et al.   ANNALS OF THE RHEUMATIC DISEASES

A four-gene biomarker predicts skin disease in patients with diffuse cutaneous systemic sclerosis

(2010) G. Farina et al.   ARTHRITIS AND RHEUMATISM

Systemic sclerosis and lupus: Points in an interferon-mediated continuum

(2010) Shervin Assassi et al.   ARTHRITIS AND RHEUMATISM

An open-label, single-dose bioavailability study of the pharmacokinetics of CAT-354 after subcutaneous and intravenous administration in healthy males

(2010) Chad K. Oh et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Trends in Risks Associated With New Drug Development: Success Rates for Investigational Drugs

(2010) J A DiMasi et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Interferon-alpha: A Therapeutic Target in Systemic Lupus Erythematosus

(2010) Mary K. Crow   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

Neutralization of interferon-α/β-inducible genes and downstream effect in a phase I trial of an anti-interferon-α monoclonal antibody in systemic lupus erythematosus

(2009) Yihong Yao et al.   ARTHRITIS AND RHEUMATISM

Interleukin-6 and type I interferon-regulated genes and chemokines mark disease activity in dermatomyositis

(2009) Hatice Bilgic et al.   ARTHRITIS AND RHEUMATISM

Serum type I interferon activity is dependent on maternal diagnosis in anti-SSA/Ro–positive mothers of children with neonatal lupus

(2008) Timothy B. Niewold et al.   ARTHRITIS AND RHEUMATISM

Combined analysis of monocyte and lymphocyte messenger RNA expression with serum protein profiles in patients with scleroderma

(2008) Hangjun Duan et al.   ARTHRITIS AND RHEUMATISM

Interferons and scleroderma—A new clue to understanding the pathogenesis of scleroderma?

(2008) Luiz Felipe Leomil Coelho et al.   IMMUNOLOGY LETTERS

Capillary Regeneration in Scleroderma: Stem Cell Therapy Reverses Phenotype?

(2008) Jo N. Fleming et al.   PLoS One

Type I Interferon: Potential Therapeutic Target for Psoriasis?

(2008) Yihong Yao et al.   PLoS One