Bioprinting and Organ-on-Chip Applications Towards Personalized Medicine for Bone Diseases

Mimicking liver sinusoidal structures and functions using a 3D-configured microfluidic chip

(2017) Yu Du et al.   LAB ON A CHIP

A 3D neurovascular microfluidic model consisting of neurons, astrocytes and cerebral endothelial cells as a blood–brain barrier

(2017) Giulia Adriani et al.   LAB ON A CHIP

Design and Construction of a Multi-Organ Microfluidic Chip Mimicking the in vivo Microenvironment of Lung Cancer Metastasis

(2016) Zhiyun Xu et al.   ACS Applied Materials & Interfaces

Rapid Continuous Multimaterial Extrusion Bioprinting

(2016) Wanjun Liu et al.   ADVANCED MATERIALS

Human in vitro 3D co-culture model to engineer vascularized bone-mimicking tissues combining computational tools and statistical experimental approach

(2016) Simone Bersini et al.   BIOMATERIALS

Bioprinting 3D microfibrous scaffolds for engineering endothelialized myocardium and heart-on-a-chip

(2016) Yu Shrike Zhang et al.   BIOMATERIALS

3D bioprinting for engineering complex tissues

(2016) Christian Mandrycky et al.   BIOTECHNOLOGY ADVANCES

Cell-microenvironment interactions and architectures in microvascular systems

(2016) Simone Bersini et al.   BIOTECHNOLOGY ADVANCES

Organoid-on-a-chip and body-on-a-chip systems for drug screening and disease modeling

(2016) Aleksander Skardal et al.   DRUG DISCOVERY TODAY

The RANKL/RANK/OPG signal trail: significance of genetic polymorphisms in the etiology of postmenopausal osteoporosis

(2016) Hubert Wolski et al.   Ginekologia Polska

Beating heart on a chip: a novel microfluidic platform to generate functional 3D cardiac microtissues

(2016) Anna Marsano et al.   LAB ON A CHIP

Microengineered cancer-on-a-chip platforms to study the metastatic microenvironment

(2016) R. Portillo-Lara et al.   LAB ON A CHIP

A 3D vascularized bone remodeling model combining osteoblasts and osteoclasts in a CaP nanoparticle-enriched matrix

(2016) Matilde Bongio et al.   Nanomedicine

A 3D bioprinting system to produce human-scale tissue constructs with structural integrity

(2016) Hyun-Wook Kang et al.   NATURE BIOTECHNOLOGY

Engineering a Brain Cancer Chip for High-throughput Drug Screening

(2016) Yantao Fan et al.   Scientific Reports

Hierarchical Fabrication of Engineered Vascularized Bone Biphasic Constructs via Dual 3D Bioprinting: Integrating Regional Bioactive Factors into Architectural Design

(2016) Haitao Cui et al.   Advanced Healthcare Materials

Bone Quality in Paget’s Disease of Bone

(2016) Frederick R. Singer   Current Osteoporosis Reports

Novel technologies and emerging biomarkers for personalized cancer immunotherapy

(2016) Jianda Yuan et al.   Journal for ImmunoTherapy of Cancer

Microfluidic Bioprinting of Heterogeneous 3D Tissue Constructs Using Low-Viscosity Bioink

(2015) Cristina Colosi et al.   ADVANCED MATERIALS

Mechanically stimulated bone cells secrete paracrine factors that regulate osteoprogenitor recruitment, proliferation, and differentiation

(2015) Robert T. Brady et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inkjet-bioprinted acrylated peptides and PEG hydrogel with human mesenchymal stem cells promote robust bone and cartilage formation with minimal printhead clogging

(2015) Guifang Gao et al.   Biotechnology Journal

Improved properties of bone and cartilage tissue from 3D inkjet-bioprinted human mesenchymal stem cells by simultaneous deposition and photocrosslinking in PEG-GelMA

(2015) Guifang Gao et al.   BIOTECHNOLOGY LETTERS

Race influences warfarin dose changes associated with genetic factors

(2015) N. A. Limdi et al.   BLOOD

Facial soft biometric features for forensic face recognition

(2015) Pedro Tome et al.   FORENSIC SCIENCE INTERNATIONAL

MicroC3: an ex vivo microfluidic cis-coculture assay to test chemosensitivity and resistance of patient multiple myeloma cells

(2015) Chorom Pak et al.   Integrative Biology

Comparison of osteoclastogenesis and resorption activity of human osteoclasts on tissue culture polystyrene and on natural extracellular bone matrix in 2D and 3D

(2015) C. Kleinhans et al.   JOURNAL OF BIOTECHNOLOGY

Custom-made titanium devices as membranes for bone augmentation in implant treatment: Clinical application and the comparison with conventional titanium mesh

(2015) Tomoki Sumida et al.   JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY

3D functional and perfusable microvascular networks for organotypic microfluidic models

(2015) Simone Bersini et al.   JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

RANKL/OPG; Critical role in bone physiology

(2015) T. John Martin et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Inkjet-bioprinted acrylated peptides and PEG hydrogel with human mesenchymal stem cells promote robust bone and cartilage formation with minimal printhead clogging

(2015) Guifang Gao et al.   Biotechnology Journal

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells

(2015) Ariosto Silva et al.   Jove-Journal of Visualized Experiments

Gender comparison of factors associated with age-related differences in bone mineral density

(2015) Hrafnhildur L. Runolfsdottir et al.   Archives of Osteoporosis

Three-Dimensional Microfluidic Tri-Culture Model of the Bone Marrow Microenvironment for Study of Acute Lymphoblastic Leukemia

(2015) Allison Bruce et al.   PLoS One

Microfluidic techniques for development of 3D vascularized tissue

(2014) Anwarul Hasan et al.   BIOMATERIALS

Engineering a morphogenetically active hydrogel for bioprinting of bioartificial tissue derived from human osteoblast-like SaOS-2 cells

(2014) Meik Neufurth et al.   BIOMATERIALS

A microfluidic 3D in vitro model for specificity of breast cancer metastasis to bone

(2014) Simone Bersini et al.   BIOMATERIALS

Bioactive nanoparticles stimulate bone tissue formation in bioprinted three-dimensional scaffold and human mesenchymal stem cells

(2014) Guifang Gao et al.   Biotechnology Journal

A microfluidic coculture and multiphoton FAD analysis assay provides insight into the influence of the bone microenvironment on prostate cancer cells

(2014) Lauren L. Bischel et al.   Integrative Biology

Modulation of Selectin-Mediated Adhesion of Flowing Lymphoma and Bone Marrow Cells by Immobilized SDF-1

(2014) Elizabeth Hedges et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Biomechanics and Mechanobiology of Trabecular Bone: A Review

(2014) Ramin Oftadeh et al.   JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

Prolonged presence of VEGF promotes vascularization in 3D bioprinted scaffolds with defined architecture

(2014) Michelle T. Poldervaart et al.   JOURNAL OF CONTROLLED RELEASE

Direct but not indirect co-culture with osteogenically differentiated human bone marrow stromal cells increases RANKL/OPG ratio in human breast cancer cells generating bone metastases

(2014) Chiara Arrigoni et al.   Molecular Cancer

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

Genetic polymorphisms in the mevalonate pathway affect the therapeutic response to alendronate treatment in postmenopausal Chinese women with low bone mineral density

(2014) C Wang et al.   PHARMACOGENOMICS JOURNAL

Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation

(2014) Jessie S. Jeon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tunable hydrogel composite with two-step processing in combination with innovative hardware upgrade for cell-based three-dimensional bioprinting

(2013) Silke Wüst et al.   Acta Biomaterialia

Differences between healthy hematopoietic progenitors and leukemia cells with respect to CD44 mediated rolling versus adherence behavior on hyaluronic acid coated surfaces

(2013) Maximilian Hanke et al.   BIOMATERIALS

A Preclinical Assay for Chemosensitivity in Multiple Myeloma

(2013) Z. P. Khin et al.   CANCER RESEARCH

Differential Expression of the RANKL/RANK/OPG System Is Associated with Bone Metastasis in Human Non-Small Cell Lung Cancer

(2013) Xianbo Peng et al.   PLoS One

Patient-Specific 3D Microfluidic Tissue Model for Multiple Myeloma

(2013) Wenting Zhang et al.   TISSUE ENGINEERING PART C-METHODS

Postmenopausal osteoporosis

(2013) Dima L. Diab et al.   Current Opinion in Endocrinology Diabetes and Obesity

Gelatin methacrylate as a promising hydrogel for 3D microscale organization and proliferation of dielectrophoretically patterned cells

(2012) Javier Ramón-Azcón et al.   LAB ON A CHIP

High- and low-dose OPG–Fc cause osteopetrosis-like changes in infant mice

(2012) Renee Bargman et al.   PEDIATRIC RESEARCH

Disorders of Bone Remodeling

(2011) Xu Feng et al.   Annual Review of Pathology-Mechanisms of Disease

Stat5: From Breast Development to Cancer Prognosis, Prediction, and Progression

(2011) David Tweardy et al.   JOURNAL OF CLINICAL ONCOLOGY

Distinct Tissue Formation by Heterogeneous Printing of Osteo- and Endothelial Progenitor Cells

(2011) Natalja E. Fedorovich et al.   TISSUE ENGINEERING PART A

Layer-by-Layer Tissue Microfabrication Supports Cell Proliferation In Vitro and In Vivo

(2011) Sylvain Catros et al.   TISSUE ENGINEERING PART C-METHODS

Organ printing: the future of bone regeneration?

(2011) Natalja E. Fedorovich et al.   TRENDS IN BIOTECHNOLOGY

Cell-laden microengineered gelatin methacrylate hydrogels

(2010) Jason W. Nichol et al.   BIOMATERIALS

3D powder printed calcium phosphate implants for reconstruction of cranial and maxillofacial defects

(2010) Uwe Klammert et al.   JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY

Engineering anatomically shaped human bone grafts

(2009) Warren L. Grayson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A unique three-dimensional model for evaluating the impact of therapy on multiple myeloma

(2008) J. Kirshner et al.   BLOOD

Fluid Flow Induced Calcium Response in Bone Cell Network

(2008) Bo Huo et al.   Cellular and Molecular Bioengineering

Inhibition of RANK/RANKL signal transduction pathway: A promising approach for osteoporosis treatment

(2008) Yu-Di Bai et al.   MEDICAL HYPOTHESES

Three-Dimensional Fiber Deposition of Cell-Laden, Viable, Patterned Constructs for Bone Tissue Printing

(2008) Natalja E. Fedorovich et al.   TISSUE ENGINEERING PART A