3D functional and perfusable microvascular networks for organotypic microfluidic models

A microfluidic 3D in vitro model for specificity of breast cancer metastasis to bone

(2014) Simone Bersini et al.   BIOMATERIALS

Generation of 3D functional microvascular networks with human mesenchymal stem cells in microfluidic systems

(2014) Jessie S. Jeon et al.   Integrative Biology

Engineering interconnected 3D vascular networks in hydrogels using molded sodium alginate lattice as the sacrificial template

(2014) Xue-Ying Wang et al.   LAB ON A CHIP

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

Bone marrow–on–a–chip replicates hematopoietic niche physiology in vitro

(2014) Yu-suke Torisawa et al.   NATURE METHODS

Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation

(2014) Jessie S. Jeon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Micropatterned Cell–Cell Interactions Enable Functional Encapsulation of Primary Hepatocytes in Hydrogel Microtissues

(2014) Cheri Y. Li et al.   TISSUE ENGINEERING PART A

Reconstituting Vascular Microenvironment of Neural Stem Cell Niche in Three-Dimensional Extracellular Matrix

(2014) Yoojin Shin et al.   Advanced Healthcare Materials

An Integrin-Linked Machinery of Cytoskeletal Regulation that Enables Experimental Tumor Initiation and Metastatic Colonization

(2013) Tsukasa Shibue et al.   CANCER CELL

Vascular permeability changes involved in tumor metastasis

(2013) Jonathan García-Román et al.   CANCER LETTERS

Mechanisms Governing Metastatic Dormancy and Reactivation

(2013) Filippo G. Giancotti   CELL

In vitro models of the metastatic cascade: from local invasion to extravasation

(2013) S. Bersini et al.   DRUG DISCOVERY TODAY

Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment

(2013) Kyung-Jin Jang et al.   Integrative Biology

Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation

(2013) Hyun Jung Kim et al.   Integrative Biology

Microscopic Matrix Remodeling Precedes Endothelial Morphological Changes During Capillary Morphogenesis

(2013) Claire McLeod et al.   JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

A microfluidic platform for generating large-scale nearly identical human microphysiological vascularized tissue arrays

(2013) Yu-Hsiang Hsu et al.   LAB ON A CHIP

Engineering of functional, perfusable 3D microvascular networks on a chip

(2013) Sudong Kim et al.   LAB ON A CHIP

A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence

(2013) Joanna Kaplon et al.   NATURE

In Vitro Model of Tumor Cell Extravasation

(2013) Jessie S. Jeon et al.   PLoS One

Deconstructing Dimensionality

(2013) M. A. Schwartz et al.   SCIENCE

Control of Perfusable Microvascular Network Morphology Using a Multiculture Microfluidic System

(2013) Jordan A. Whisler et al.   TISSUE ENGINEERING PART C-METHODS

A novel in vitro model system for smooth muscle differentiation from human embryonic stem cell-derived mesenchymal cells

(2012) Xia Guo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Tubeless microfluidic angiogenesis assay with three-dimensional endothelial-lined microvessels

(2012) Lauren L. Bischel et al.   BIOMATERIALS

Species differences in drug transporters and implications for translating preclinical findings to humans

(2012) Xiaoyan Chu et al.   Expert Opinion on Drug Metabolism & Toxicology

Anastomosis of endothelial sprouts forms new vessels in a tissue analogue of angiogenesis

(2012) Jonathan W. Song et al.   Integrative Biology

Mechanism of a flow-gated angiogenesis switch: early signaling events at cell–matrix and cell–cell junctions

(2012) Vernella Vickerman et al.   Integrative Biology

In vitro formation and characterization of a perfusable three-dimensional tubular capillary network in microfluidic devices

(2012) Ju Hun Yeon et al.   LAB ON A CHIP

A microfluidic-based device for study of transendothelial invasion of tumor aggregates in realtime

(2012) Qian Zhang et al.   LAB ON A CHIP

Characterization of a microfluidic in vitro model of the blood-brain barrier (μBBB)

(2012) Ross Booth et al.   LAB ON A CHIP

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

(2012) Hyun Jung Kim et al.   LAB ON A CHIP

A modular approach to create a neurovascular unit-on-a-chip

(2012) Anil Kumar H. Achyuta et al.   LAB ON A CHIP

Outgrowth of single oncogene-expressing cells from suppressive epithelial environments

(2012) Cheuk T. Leung et al.   NATURE

Microfluidic assay for simultaneous culture of multiple cell types on surfaces or within hydrogels

(2012) Yoojin Shin et al.   Nature Protocols

In vitro microvessels for the study of angiogenesis and thrombosis

(2012) Y. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Endothelial Progenitor Cells Induce Extracellular Signal-Regulated Kinase-Dependent Differentiation of Mesenchymal Stem Cells into Smooth Muscle Cells upon Cocultivation

(2012) Sebastian M. Goerke et al.   TISSUE ENGINEERING PART A

Tumor Metastasis: Molecular Insights and Evolving Paradigms

(2011) Scott Valastyan et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Cancer Cells Regulate Biomechanical Properties of Human Microvascular Endothelial Cells

(2011) Claudia Tanja Mierke   JOURNAL OF BIOLOGICAL CHEMISTRY

Integration of intra- and extravasation in one cell-based microfluidic chip for the study of cancer metastasis

(2011) Min Kyeong Shin et al.   LAB ON A CHIP

A Perspective on Cancer Cell Metastasis

(2011) C. L. Chaffer et al.   SCIENCE

Transmural Flow Modulates Cell and Fluid Transport Functions of Lymphatic Endothelium

(2010) Dimana O. Miteva et al.   CIRCULATION RESEARCH

Visualizing extravasation dynamics of metastatic tumor cells

(2010) K. Stoletov et al.   JOURNAL OF CELL SCIENCE

A micro cell culture analog (µCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs

(2009) Jong Hwan Sung et al.   LAB ON A CHIP

Genes that mediate breast cancer metastasis to the brain

(2009) Paula D. Bos et al.   NATURE

Microfluidic Endothelium for Studying the Intravascular Adhesion of Metastatic Breast Cancer Cells

(2009) Jonathan W. Song et al.   PLoS One

A novel system for evaluation of drug mixtures for potential efficacy in treating multidrug resistant cancers

(2008) Daniel A. Tatosian et al.   BIOTECHNOLOGY AND BIOENGINEERING