The meteorology of cytokine storms, and the clinical usefulness of this knowledge

Variants of the EAAT2 Glutamate Transporter Gene Promoter Are Associated with Cerebral Palsy in Preterm Infants

(2017) Shavanthi Rajatileka et al.   MOLECULAR NEUROBIOLOGY

Treatment for Rheumatoid Arthritis and Risk of Alzheimer’s Disease: A Nested Case-Control Analysis

(2016) Richard C. Chou et al.   CNS DRUGS

Increased Amyloid Precursor Protein and Tau Expression Manifests as Key Secondary Cell Death in Chronic Traumatic Brain Injury

(2016) Sandra A. Acosta et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Excess cerebral TNF causing glutamate excitotoxicity rationalizes treatment of neurodegenerative diseases and neurogenic pain by anti-TNF agents

(2016) Ian A. Clark et al.   Journal of Neuroinflammation

Clinical Outcomes of Transplanted Modified Bone Marrow–Derived Mesenchymal Stem Cells in Stroke

(2016) Gary K. Steinberg et al.   STROKE

Letter by Clark Regarding Article, “Clinical Outcomes of Transplanted Modified Bone Marrow–Derived Mesenchymal Stem Cells in Stroke: A Phase 1/2a Study”

(2016) Ian A. Clark   STROKE

Mapping synaptic glutamate transporter dysfunction in vivo to regions surrounding Aβ plaques by iGluSnFR two-photon imaging

(2016) J. K. Hefendehl et al.   Nature Communications

Molecular cloning, expression and the adjuvant effects of interleukin-8 of channel catfish (Ictalurus Punctatus) against Streptococcus iniae

(2016) Erlong Wang et al.   Scientific Reports

Amyloid β: one of three danger-associated molecules that are secondary inducers of the proinflammatory cytokines that mediate Alzheimer's disease

(2015) I A Clark et al.   BRITISH JOURNAL OF PHARMACOLOGY

The interface between delirium and dementia in elderly adults

(2015) Tamara G Fong et al.   LANCET NEUROLOGY

The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1β

(2015) Jean-Michel Rondeau et al.   mAbs

Molecular Cloning, Characterization, and Expression Analysis of a Prolyl 4-Hydroxylase from the Marine Sponge Chondrosia reniformis

(2015) Marina Pozzolini et al.   MARINE BIOTECHNOLOGY

A Neurologist’s Guide to TNF Biology and to the Principles behind the Therapeutic Removal of Excess TNF in Disease

(2015) Ian A. Clark et al.   NEURAL PLASTICITY

Perispinal Etanercept for Post-Stroke Neurological and Cognitive Dysfunction: Scientific Rationale and Current Evidence

(2014) Tracey A. Ignatowski et al.   CNS DRUGS

Differential expression, modulation and bioactivity of distinct fish IL-12 isoforms: Implication towards the evolution of Th1-like immune responses

(2014) Tiehui Wang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The effect of intravenous interleukin-1 receptor antagonist on inflammatory mediators in cerebrospinal fluid after subarachnoid haemorrhage: a phase II randomised controlled trial

(2014) Navneet Singh et al.   Journal of Neuroinflammation

Inflammation-sleep interface in brain disease: TNF, insulin, orexin

(2014) Ian A Clark et al.   Journal of Neuroinflammation

A novel human anti-interleukin-1β neutralizing monoclonal antibody showing in vivo efficacy

(2014) Angeline XH Goh et al.   mAbs

Long-term potentiation of glycinergic synapses triggered by interleukin 1 

(2014) A. M. Chirila et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolution of TNF-induced apoptosis reveals 550 My of functional conservation

(2014) Steven D. Quistad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid Burden, Neuroinflammation, and Links to Cognitive Decline After Ischemic Stroke

(2014) Alexander Thiel et al.   STROKE

Inconsistencies and Controversies Surrounding the Amyloid Hypothesis of Alzheimer's Disease

(2014) Gary P Morris et al.   Acta Neuropathologica Communications

Treatment implications of the altered cytokine-insulin axis in neurodegenerative disease

(2013) Ian A. Clark et al.   BIOCHEMICAL PHARMACOLOGY

Inflammation and white matter degeneration persist for years after a single traumatic brain injury

(2013) Victoria E. Johnson et al.   BRAIN

Learning and memory ... and the immune system

(2013) I. Marin et al.   LEARNING & MEMORY

Neuroinflammation and Neuronal Loss Precede Aβ Plaque Deposition in the hAPP-J20 Mouse Model of Alzheimer’s Disease

(2013) Amanda L. Wright et al.   PLoS One

Treating inflammation by blocking interleukin-1 in humans

(2013) Charles A. Dinarello et al.   SEMINARS IN IMMUNOLOGY

At the extreme end of the psychoneuroimmunological spectrum: Delirium as a maladaptive sickness behaviour response

(2012) Colm Cunningham et al.   BRAIN BEHAVIOR AND IMMUNITY

Selective TNF Inhibition for Chronic Stroke and Traumatic Brain Injury

(2012) Edward Tobinick et al.   CNS DRUGS

Brain Protection from Stroke with Intravenous TNFα Decoy Receptor-Trojan Horse Fusion Protein

(2012) Rachita K Sumbria et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Into the Eye of the Cytokine Storm

(2012) J. R. Tisoncik et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Dynamics of a Cytokine Storm

(2012) Hao Hong Yiu et al.   PLoS One

Inflammation after trauma: Microglial activation and traumatic brain injury

(2011) Anil F. Ramlackhansingh et al.   ANNALS OF NEUROLOGY

Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes

(2011) Ying Liu et al.   JOURNAL OF PATHOLOGY

Astrocytes are important mediators of Aβ-induced neurotoxicity and tau phosphorylation in primary culture

(2011) C J Garwood et al.   Cell Death & Disease

Tumor necrosis factor-alpha regulates the Hypocretin system via mRNA degradation and ubiquitination

(2010) Shuqin Zhan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Lack of aggression and anxiolytic-like behavior in TNF receptor (TNF-R1 and TNF-R2) deficient mice

(2010) Ankur Patel et al.   BRAIN BEHAVIOR AND IMMUNITY

Rapid brain penetration of interleukin-1 receptor antagonist in rat cerebral ischaemia: pharmacokinetics, distribution, protection

(2010) AD Greenhalgh et al.   BRITISH JOURNAL OF PHARMACOLOGY

Nonresolving Inflammation

(2010) Carl Nathan et al.   CELL

Intravenous Anakinra can Achieve Experimentally Effective Concentrations in the Central Nervous System within a Therapeutic Time Window: Results of a Dose-Ranging Study

(2010) James Galea et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The roles of TNF in brain dysfunction and disease

(2010) Ian A. Clark et al.   PHARMACOLOGY & THERAPEUTICS

Identification of a Novel IL-1 Cytokine Family Member in Teleost Fish

(2009) T. Wang et al.   JOURNAL OF IMMUNOLOGY

Identification and expression analysis of two fish-specific IL-6 cytokine family members, the ciliary neurotrophic factor (CNTF)-like and M17 genes, in rainbow trout Oncorhynchus mykiss

(2009) Tiehui Wang et al.   MOLECULAR IMMUNOLOGY

Is human malarial coma caused, or merely deepened, by sequestration?

(2009) Ian A. Clark et al.   TRENDS IN PARASITOLOGY

Tumor Necrosis Factor-α Potentiates Intraneuronal Ca2+Signaling via Regulation of the Inositol 1,4,5-Trisphosphate Receptor

(2008) Keigan M. Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell Death after Spinal Cord Injury Is Exacerbated by Rapid TNF -Induced Trafficking of GluR2-Lacking AMPARs to the Plasma Membrane

(2008) A. R. Ferguson et al.   JOURNAL OF NEUROSCIENCE

Sickness behaviour pushed too far - the basis of the syndrome seen in severe protozoal, bacterial, and viral, diseases, and post-trauma

(2008) Ian A Clark et al.   MALARIA JOURNAL

Tumor Necrosis Factor-α Modulates Survival, Proliferation, and Neuronal Differentiation in Neonatal Subventricular Zone Cell Cultures

(2008) Liliana Bernardino et al.   STEM CELLS