Mechanisms for initiating cellular DNA replication

Open-ringed structure of the Cdt1–Mcm2–7 complex as a precursor of the MCM double hexamer

(2017) Yuanliang Zhai et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanism and timing of Mcm2–7 ring closure during DNA replication origin licensing

(2017) Simina Ticau et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis of Mcm2–7 replicative helicase loading by ORC–Cdc6 and Cdt1

(2017) Zuanning Yuan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of eukaryotic CMG helicase at a replication fork and implications to replisome architecture and origin initiation

(2017) Roxana Georgescu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Open-ringed structure of the Cdt1–Mcm2–7 complex as a precursor of the MCM double hexamer

(2017) Yuanliang Zhai et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanism and timing of Mcm2–7 ring closure during DNA replication origin licensing

(2017) Simina Ticau et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis of Mcm2–7 replicative helicase loading by ORC–Cdc6 and Cdt1

(2017) Zuanning Yuan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Review: The lord of the rings: Structure and mechanism of the sliding clamp loader

(2016) Brian A. Kelch   BIOPOLYMERS

Replication timing and transcriptional control: beyond cause and effect — part III

(2016) Juan Carlos Rivera-Mulia et al.   CURRENT OPINION IN CELL BIOLOGY

MCM: one ring to rule them all

(2016) Tom D Deegan et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Mechanism of Archaeal MCM Helicase Recruitment to DNA Replication Origins

(2016) Rachel Y. Samson et al.   MOLECULAR CELL

The bacterial DnaA-trio replication origin element specifies single-stranded DNA initiator binding

(2016) Tomas T. Richardson et al.   NATURE

Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation

(2016) Zuanning Yuan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Diverged composition and regulation of theTrypanosoma bruceiorigin recognition complex that mediates DNA replication initiation

(2016) Catarina A. Marques et al.   NUCLEIC ACIDS RESEARCH

DciA is an ancestral replicative helicase operator essential for bacterial replication initiation

(2016) Pierre Brézellec et al.   Nature Communications

Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation

(2016) Zuanning Yuan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Single-Molecule Studies of Origin Licensing Reveal Mechanisms Ensuring Bidirectional Helicase Loading

(2015) Simina Ticau et al.   CELL

Structure of the eukaryotic MCM complex at 3.8 Å

(2015) Ningning Li et al.   NATURE

Crystal structure of the eukaryotic origin recognition complex

(2015) Franziska Bleichert et al.   NATURE

Regulated eukaryotic DNA replication origin firing with purified proteins

(2015) Joseph T. P. Yeeles et al.   NATURE

DNA replication origin activation in space and time

(2015) Michalis Fragkos et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structure and primase-mediated activation of a bacterial dodecameric replicative helicase

(2015) Alexandre Bazin et al.   NUCLEIC ACIDS RESEARCH

Insights into the Initiation of Eukaryotic DNA Replication

(2015) Irina Bruck et al.   Nucleus

Insights into the Initiation of Eukaryotic DNA Replication

(2015) Irina Bruck et al.   Nucleus

Replication initiation and genome instability: a crossroads for DNA and RNA synthesis

(2014) Jacqueline H. Barlow et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

DNA Replication and Oncogene-Induced Replicative Stress

(2014) Stephanie A. Hills et al.   CURRENT BIOLOGY

Prereplicative complexes assembled in vitro support origin-dependent and independent DNA replication

(2014) K. F. On et al.   EMBO JOURNAL

Structural and mechanistic insights into Mcm2–7 double-hexamer assembly and function

(2014) Jingchuan Sun et al.   GENES & DEVELOPMENT

Nucleotide and Partner-Protein Control of Bacterial Replicative Helicase Structure and Function

(2014) Melania S. Strycharska et al.   MOLECULAR CELL

Multiple Functions for Mcm2–7 ATPase Motifs during Replication Initiation

(2014) Sukhyun Kang et al.   MOLECULAR CELL

Origin Licensing Requires ATP Binding and Hydrolysis by the MCM Replicative Helicase

(2014) Gideon Coster et al.   MOLECULAR CELL

Prereplication-complex formation: a molecular double take?

(2014) Hasan Yardimci et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A conserved MCM single-stranded DNA binding element is essential for replication initiation

(2014) Clifford A Froelich et al.   eLife

The Bacterial DnaC Helicase Loader Is a DnaB Ring Breaker

(2013) Ernesto Arias-Palomo et al.   CELL

Loading strategies of ring-shaped nucleic acid translocases and helicases

(2013) Valerie L O'Shea et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

ATPase-dependent quality control of DNA replication origin licensing

(2013) Jordi Frigola et al.   NATURE

Cryo-EM structure of a helicase loading intermediate containing ORC–Cdc6–Cdt1–MCM2-7 bound to DNA

(2013) Jingchuan Sun et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

In the absence of ATPase activity, pre-RC formation is blocked prior to MCM2-7 hexamer dimerization

(2013) C. Evrin et al.   NUCLEIC ACIDS RESEARCH

The ORC/Cdc6/MCM2-7 complex facilitates MCM2-7 dimerization during prereplicative complex formation

(2013) Cecile Evrin et al.   NUCLEIC ACIDS RESEARCH

Helicase Activation and Establishment of Replication Forks at Chromosomal Origins of Replication

(2013) S. Tanaka et al.   Cold Spring Harbor Perspectives in Biology

Helicase Loading at Chromosomal Origins of Replication

(2013) S. P. Bell et al.   Cold Spring Harbor Perspectives in Biology

Regulating DNA Replication in Eukarya

(2013) K. Siddiqui et al.   Cold Spring Harbor Perspectives in Biology

Specificity and Function of Archaeal DNA Replication Initiator Proteins

(2013) Rachel Y. Samson et al.   Cell Reports

A Meier-Gorlin syndrome mutation in a conserved C-terminal helix of Orc6 impedes origin recognition complex formation

(2013) Franziska Bleichert et al.   eLife

The Hexameric Helicase DnaB Adopts a Nonplanar Conformation during Translocation

(2012) Ornchuma Itsathitphaisarn et al.   CELL

Architecture and Conservation of the Bacterial DNA Replication Machinery, an Underexploited Drug Target

(2012) Andrew Robinson et al.   CURRENT DRUG TARGETS

Activation of the replicative DNA helicase: breaking up is hard to do

(2012) Dominik Boos et al.   CURRENT OPINION IN CELL BIOLOGY

The BAH domain of ORC1 links H4K20me2 to DNA replication licensing and Meier–Gorlin syndrome

(2012) Alex J. Kuo et al.   NATURE

Helicobacter pylori oriC —the first bipartite origin of chromosome replication in Gram-negative bacteria

(2012) Rafał Donczew et al.   NUCLEIC ACIDS RESEARCH

Identification of ORC1/CDC6-Interacting Factors in Trypanosoma brucei Reveals Critical Features of Origin Recognition Complex Architecture

(2012) Calvin Tiengwe et al.   PLoS One

ATP-dependent conformational dynamics underlie the functional asymmetry of the replicative helicase from a minimalist eukaryote

(2012) Artem Y. Lyubimov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cdc6-Induced Conformational Changes in ORC Bound to Origin DNA Revealed by Cryo-Electron Microscopy

(2012) Jingchuan Sun et al.   STRUCTURE

Architecture of a Dodecameric Bacterial Replicative Helicase

(2012) Meike Stelter et al.   STRUCTURE

Structure and function of the AAA+ nucleotide binding pocket

(2011) Petra Wendler et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cdc45: the missing RecJ ortholog in eukaryotes?

(2011) Luis Sanchez-Pulido et al.   BIOINFORMATICS

The nuts and bolts of ring-translocase structure and mechanism

(2011) Artem Y Lyubimov et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

MCM2-7 Form Double Hexamers at Licensed Origins inXenopusEgg Extract

(2011) Agnieszka Gambus et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Role for Dormant Origins in Tumor Suppression

(2011) Kathleen Klotz-Noack et al.   MOLECULAR CELL

Two oppositely oriented arrays of low-affinity recognition sites in oriC guide progressive binding of DnaA during Escherichia coli pre-RC assembly

(2011) Tania A. Rozgaja et al.   MOLECULAR MICROBIOLOGY

DNA stretching by bacterial initiators promotes replication origin opening

(2011) Karl E. Duderstadt et al.   NATURE

Mutations in origin recognition complex gene ORC4 cause Meier-Gorlin syndrome

(2011) Duane L Guernsey et al.   NATURE GENETICS

Mutations in ORC1, encoding the largest subunit of the origin recognition complex, cause microcephalic primordial dwarfism resembling Meier-Gorlin syndrome

(2011) Louise S Bicknell et al.   NATURE GENETICS

Mutations in the pre-replication complex cause Meier-Gorlin syndrome

(2011) Louise S Bicknell et al.   NATURE GENETICS

The structural basis for MCM2–7 helicase activation by GINS and Cdc45

(2011) Alessandro Costa et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular determinants of origin discrimination by Orc1 initiators in archaea

(2011) Erin C. Dueber et al.   NUCLEIC ACIDS RESEARCH

How a DNA Polymerase Clamp Loader Opens a Sliding Clamp

(2011) B. A. Kelch et al.   SCIENCE

Treslin Collaborates with TopBP1 in Triggering the Initiation of DNA Replication

(2010) Akiko Kumagai et al.   CELL

Homology explains the functional similarities of Treslin/Ticrr and Sld3

(2010) Luis Sanchez-Pulido et al.   CURRENT BIOLOGY

A vertebrate gene, ticrr, is an essential checkpoint and replication regulator

(2010) C. L. Sansam et al.   GENES & DEVELOPMENT

How do Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells?

(2010) K. Labib   GENES & DEVELOPMENT

Chromatin signatures of the Drosophila replication program

(2010) M. L. Eaton et al.   GENOME RESEARCH

Characterization and Structure Determination of the Cdt1 Binding Domain of Human Minichromosome Maintenance (Mcm) 6

(2010) Zhun Wei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A WD-Repeat Protein Stabilizes ORC Binding to Chromatin

(2010) Zhen Shen et al.   MOLECULAR CELL

Mec1 Is One of Multiple Kinases that Prime the Mcm2-7 Helicase for Phosphorylation by Cdc7

(2010) John C.W. Randell et al.   MOLECULAR CELL

Primase Directs the Release of DnaC from DnaB

(2010) Magdalena Makowska-Grzyska et al.   MOLECULAR CELL

Concerted Loading of Mcm2–7 Double Hexamers around DNA during DNA Replication Origin Licensing

(2009) Dirk Remus et al.   CELL

Localized melting of duplex DNA by Cdc6/Orc1 at the DNA replication origin in the hyperthermophilic archaeon Pyrococcus furiosus

(2009) Fujihiko Matsunaga et al.   EXTREMOPHILES

Drosophila ORC localizes to open chromatin and marks sites of cohesin complex loading

(2009) H. K. MacAlpine et al.   GENOME RESEARCH

Molecular Interplay between the Replicative Helicase DnaC and Its Loader Protein DnaI from Geobacillus kaustophilus

(2009) Kuang-Lei Tsai et al.   JOURNAL OF MOLECULAR BIOLOGY

A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication

(2009) C. Evrin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A conserved mechanism for replication origin recognition and binding in archaea

(2008) Alan I. Majerník et al.   BIOCHEMICAL JOURNAL

Structural Synergy and Molecular Crosstalk between Bacterial Helicase Loaders and Replication Initiators

(2008) Melissa L. Mott et al.   CELL

Multiple ATP Binding Is Required to Stabilize the “Activated” (Clamp Open) Clamp Loader of the T4 DNA Replication Complex

(2008) Paola Pietroni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Mcm2-7 Complex Has In Vitro Helicase Activity

(2008) Matthew L. Bochman et al.   MOLECULAR CELL

The crystal structure of a replicative hexameric helicase DnaC and its complex with single-stranded DNA

(2008) Yu-Hua Lo et al.   NUCLEIC ACIDS RESEARCH

Interaction between HMGA1a and the origin recognition complex creates site-specific replication origins

(2008) A. W. Thomae et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA