Insights into the Initiation of Eukaryotic DNA Replication

Single-Molecule Studies of Origin Licensing Reveal Mechanisms Ensuring Bidirectional Helicase Loading

(2015) Simina Ticau et al.   CELL

The Replication Initiation Protein Sld3/Treslin Orchestrates the Assembly of the Replication Fork Helicase during S Phase

(2015) Irina Bruck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dpb11 Protein Helps Control Assembly of the Cdc45·Mcm2-7·GINS Replication Fork Helicase

(2015) Nalini Dhingra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Major Role of DNA Polymerase δ in Replication of Both the Leading and Lagging DNA Strands

(2015) Robert E. Johnson et al.   MOLECULAR CELL

Regulated eukaryotic DNA replication origin firing with purified proteins

(2015) Joseph T. P. Yeeles et al.   NATURE

A reconstituted system reveals how activating and inhibitory interactions control DDK dependent assembly of the eukaryotic replicative helicase

(2015) M. Carmen Herrera et al.   NUCLEIC ACIDS RESEARCH

Conserved mechanism for coordinating replication fork helicase assembly with phosphorylation of the helicase

(2015) Irina Bruck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reconstitution of a eukaryotic replisome reveals suppression mechanisms that define leading/lagging strand operation

(2015) Roxana E Georgescu et al.   eLife

The quaternary structure of the eukaryotic DNA replication proteins Sld7 and Sld3

(2015) Hiroshi Itou et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Switch on the engine: how the eukaryotic replicative helicase MCM2–7 becomes activated

(2014) Silvia Tognetti et al.   CHROMOSOMA

A unique DNA entry gate serves for regulated loading of the eukaryotic replicative helicase MCM2–7 onto DNA

(2014) Stefan A. Samel et al.   GENES & DEVELOPMENT

The Dbf4-Cdc7 Kinase Promotes Mcm2-7 Ring Opening to Allow for Single-stranded DNA Extrusion and Helicase Assembly

(2014) Irina Bruck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Domain within the helicase subunit Mcm4 integrates multiple kinase signals to control DNA replication initiation and fork progression

(2014) Y.-J. Sheu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of the Homology Domain of the Eukaryotic DNA Replication Proteins Sld3/Treslin

(2014) Hiroshi Itou et al.   STRUCTURE

DNA binding polarity, dimerization, and ATPase ring remodeling in the CMG helicase of the eukaryotic replisome

(2014) Alessandro Costa et al.   eLife

The Replication Initiation Protein Sld2 Regulates Helicase Assembly

(2013) Irina Bruck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An ORC/Cdc6/MCM2-7 Complex Is Formed in a Multistep Reaction to Serve as a Platform for MCM Double-Hexamer Assembly

(2013) Alejandra Fernández-Cid et al.   MOLECULAR CELL

ATPase-dependent quality control of DNA replication origin licensing

(2013) Jordi Frigola et al.   NATURE

Enigmatic roles of Mcm10 in DNA replication

(2013) Yee Mon Thu et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mcm10 Plays a Role in Functioning of the Eukaryotic Replicative DNA Helicase, Cdc45-Mcm-GINS

(2012) George Watase et al.   CURRENT BIOLOGY

Mcm10 plays an essential role in origin DNA unwinding after loading of the CMG components

(2012) Mai Kanke et al.   EMBO JOURNAL

Mcm10 associates with the loaded DNA helicase at replication origins and defines a novel step in its activation

(2012) Frederick van Deursen et al.   EMBO JOURNAL

The N-terminus of the human RecQL4 helicase is a homeodomain-like DNA interaction motif

(2012) Oliver Ohlenschläger et al.   NUCLEIC ACIDS RESEARCH

Selective Bypass of a Lagging Strand Roadblock by the Eukaryotic Replicative DNA Helicase

(2011) Yu V. Fu et al.   CELL

Regulation of DNA Replication through Sld3-Dpb11 Interaction Is Conserved from Yeast to Humans

(2011) Dominik Boos et al.   CURRENT BIOLOGY

Limiting replication initiation factors execute the temporal programme of origin firing in budding yeast

(2011) Davide Mantiero et al.   EMBO JOURNAL

Direct regulation of Treslin by cyclin-dependent kinase is essential for the onset of DNA replication

(2011) Akiko Kumagai et al.   JOURNAL OF CELL BIOLOGY

Stalled Fork Rescue via Dormant Replication Origins in Unchallenged S Phase Promotes Proper Chromosome Segregation and Tumor Suppression

(2011) Tsuyoshi Kawabata et al.   MOLECULAR CELL

Phosphorylation of Mcm2 modulates Mcm2–7 activity and affects the cell’s response to DNA damage

(2011) Brent E. Stead et al.   NUCLEIC ACIDS RESEARCH

Treslin Collaborates with TopBP1 in Triggering the Initiation of DNA Replication

(2010) Akiko Kumagai et al.   CELL

Origin DNA melting and unwinding in DNA replication

(2010) Dahai Gai et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

How do Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells?

(2010) K. Labib   GENES & DEVELOPMENT

Mec1 Is One of Multiple Kinases that Prime the Mcm2-7 Helicase for Phosphorylation by Cdc7

(2010) John C.W. Randell et al.   MOLECULAR CELL

Activation of the MCM2-7 Helicase by Association with Cdc45 and GINS Proteins

(2010) Ivar Ilves et al.   MOLECULAR CELL

The Dbf4–Cdc7 kinase promotes S phase by alleviating an inhibitory activity in Mcm4

(2010) Yi-Jun Sheu et al.   NATURE

Loss of DNA Replication Control Is a Potent Inducer of Gene Amplification

(2010) B. M. Green et al.   SCIENCE

Concerted Loading of Mcm2–7 Double Hexamers around DNA during DNA Replication Origin Licensing

(2009) Dirk Remus et al.   CELL

DNA replication as a target of the DNA damage checkpoint

(2009) Philip Zegerman et al.   DNA REPAIR

Dbf4-Cdc7 Phosphorylation of Mcm2 Is Required for Cell Growth

(2009) Irina Bruck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Assembly of the Cdc45-Mcm2-7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins

(2009) J.-S. Im et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication

(2009) C. Evrin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Mcm2-7 Complex Has In Vitro Helicase Activity

(2008) Matthew L. Bochman et al.   MOLECULAR CELL