Editorial Material
Immunology
Michael R. Ehrenstein, Muhammad Shipa
Summary: This Viewpoint discusses the application of experimental medicine in clinical trials to address unmet need in systemic lupus erythematosus (SLE), a prototypic autoimmune disease, with the aim of improving patient outcomes.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Engineering, Electrical & Electronic
Sonja Wogrin
Summary: One of the fundamental problems of using optimization models is the trade-off between model accuracy and computational tractability when using different time series as data input. To overcome computational intractability, traditional time series aggregation methods are commonly used to reduce the dimension of input data and model size. However, these methods often overlook the importance of the resulting output error in optimization results. In this paper, the authors challenge this belief and propose output-error based TSA methods with theoretical underpinnings, which have the potential of unprecedented computational efficiency and accuracy.
IEEE TRANSACTIONS ON SMART GRID
(2023)
Article
Materials Science, Multidisciplinary
Carlos F. Guimaraes, Luca Gasperini, Alexandra P. Marques, Rui L. Reis
Summary: Microfluidic manipulation of hydrogels is a powerful tool for recapitulating functional biological architectures, and by tuning material properties and flow conditions, complex multi-compartment fibers can be created.
APPLIED MATERIALS TODAY
(2021)
Article
Behavioral Sciences
Stephan Michel, Laura Kervezee
Summary: Adaptation of physiology and behavior to seasonal changes is essential for survival. Common mechanisms, such as the circadian system, signaling molecules, and hormones, play a role in photoperiodic regulation. Understanding the relevance of these mechanisms in the face of climate change is important for humans as well.
JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Tamar B. Nobel, Smita Sihag, Xin Xing, Mahmoud Eljalby, Meier Hsu, Kay See Tan, David B. Sewell, Manjit S. Bains, Yelena Janjigian, Abraham Wu, Geoffrey Ku, David R. Jones, Daniela Molena
Summary: The presentation and prognosis of esophageal cancer recurrence differ by site, with lung oligometastases showing a more indolent course and potentially benefiting from more aggressive treatment to improve outcomes. This study suggests that a personalized approach to treatment based on the site of recurrence may be beneficial for esophageal cancer patients.
ANNALS OF THORACIC SURGERY
(2021)
Article
Rheumatology
Sevtap Tugce Ulas, Fabian Proft, Torsten Diekhoff, Valeria Rios, Judith Rademacher, Mikhail Protopopov, Juliane Greese, Iris Eshed, Lisa C. Adams, Kay Geert A. Hermann, Sarah Ohrndorf, Denis Poddubnyy, Katharina Ziegeler
Summary: The diagnostic performance of structural MRI markers is substantially lower in female patients with axSpA, leading to a higher risk of false positive findings in women.
Review
Immunology
Hee-Jeong Yang, Decheng Wang, Xin Wen, Danielle M. Weiner, Laura E. Via
Summary: Tuberculosis remains a global health problem due to issues such as lack of diagnosis and incomplete treatment, as well as drug-resistant strains of Mycobacterium tuberculosis. The development of new drugs for TB has accelerated in recent years, with a focus on addressing resistance and shortening treatment duration. Animal models are essential for predicting drug efficacy and studying disease pathology, with a variety of models offering insights into bacterial burden and lesion-specific drug concentrations. Incorporating medical imaging and drug distribution measurements in animal models is crucial for advancing drug development and improving treatment regimens.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Behavioral Sciences
A. Checa-Ros, D. Kasteleijn-Nolst Trenite, A. Edson-Scott, B. Carr, A. Cerquiglini, S. Seri
Summary: This study investigated the efficacy of blue lenses with higher transmittance in abolishing photoparoxysmal EEG response compared to the gold-standard Z1 lenses. Results showed Z1 had the best efficacy in both photosensitivity and pattern sensitivity groups, followed by the new lenses B1 + G1. For some patients, the new blue lenses may offer a more tolerable option with potentially greater effectiveness.
EPILEPSY & BEHAVIOR
(2021)
Review
Biochemistry & Molecular Biology
Jean-Louis Vincent, Tom van der Poll, John C. Marshall
Summary: Sepsis, a life-threatening organ dysfunction caused by an uncontrolled host response to infection, remains a major challenge for clinicians and trialists. The evaluation of therapeutics targeting components of host response anomalies in sepsis patients is complicated by the inability to identify those who are more likely to benefit from a specific intervention. Furthermore, the existence of multiple and diverse host response aberrations in sepsis and limited knowledge of the dysregulated biological organ system or pathway driving sepsis-induced pathology in individual patients further complicate the development of effective therapies.
Article
Medical Laboratory Technology
Friederike Haeuser, Jens Mittler, Misra Simge Hantal, Lilli Greulich, Martina Hermanns, Annette Shrestha, Oliver Kriege, Tanja Falter, Uta D. Immel, Stephanie Herold, Brigitte Schuch, Karl J. Lackner, Heidi Rossmann, Markus Radsak
Summary: A combined digital droplet PCR (ddPCR)/pyrosequencing assay system was developed for molecular genetic diagnostic applications. The results of ddPCR were in good agreement with established markers, and it showed higher sensitivity and precision in quantification. The assay is expected to be suitable for various applications.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Editorial Material
Surgery
Joshua M. Liao, Sandra L. Wong, Danny Chu
Summary: This viewpoint highlights two ways to increase participation in and benefits of surgical bundles based on insights from industries outside of health care.
Article
Ecology
Ellen L. White, Holger Klinck, Jonathan M. Bull, Paul R. White, Denise Risch
Summary: This study demonstrates the transferability of pre-trained CNN models to new acoustic environments. By fine-tuning the models with limited site-specific data, the performance of the CNN in the new environment is significantly improved.
ECOLOGICAL INFORMATICS
(2023)
Article
Agriculture, Dairy & Animal Science
Luka Juvancic, Renata Slabe-Erker, Marko Ogorevc, Adam G. Drucker, Emil Erjavec, Danijela Bojkovski
Summary: Maintaining minimum population sizes for local livestock breeds is crucial for the conservation of animal genetic resources. Financial incentives are used to motivate breeders, with differentiated payments found to be a potentially more cost-effective alternative compared to fixed payments. Findings from a stated preference survey in Slovenia suggest that willingness to accept conservation support significantly differs from actual payment levels, indicating the potential effectiveness of differentiated incentive payments.
Article
Biochemical Research Methods
Elias Ventre, Ulysse M. Herbach, Thibault Espinasse, Gerard M. Benoit, Olivier Gandrillon
Summary: The rise of single-cell data has emphasized the importance of a non-deterministic view of gene expression. The authors introduced two strategies that exploit time-course data and combine them to show that a GRN model driven by transcriptional bursting can be used as both an inference tool and a simulation tool. The integrated strategy demonstrates the benefits of using the same model for both inference and simulation.
PLOS COMPUTATIONAL BIOLOGY
(2023)
Review
Health Care Sciences & Services
Tommaso Bianchi, Tommaso Grassi, Luca Bazzurini, Giampaolo Di Martino, Serena Negri, Robert Fruscio, Gaetano Trezzi, Fabio Landoni
Summary: The pillars of modern oncology are treatment personalization and the reduction in treatment-related morbidity. In the case of surgical treatment for early-stage cervical cancer, the one-size-fits-all concept of radical hysterectomy has been the standard for decades. However, there is no consensus on the method of parametrial invasion and the required extent of parametrectomy. As a result, researchers have been investigating the feasibility and safety of less radical surgery tailored to individual patients. Preliminary results suggest that less radical surgery could significantly reduce morbidity without compromising oncological outcomes.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
