Article
Biochemistry & Molecular Biology
Constanze Banz-Jansen, Laureen P. Helweg, Barbara Kaltschmidt
Summary: Endometrial cancer is a common malignant disease in women, and targeting cancer stem cells and immunotherapy could improve prognosis and prevent cancer progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Medicine, General & Internal
Mason Marks, I. Glenn Cohen
Summary: Increasing clinical evidence may result in the approval of new psychedelic medicines. However, the FDA's draft guidance on psychedelics research includes several recommendations that may be controversial.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Cell Biology
Alexandre Balaphas, Jeremy Meyer, Raphael P. H. Meier, Emilie Liot, Nicolas C. Buchs, Bruno Roche, Christian Toso, Leo H. Buhler, Carmen Gonelle-Gispert, Frederic Ris
Summary: Anal sphincter incontinence is a chronic disease that significantly impacts quality of life, with surgery showing disappointing success rates. Stem/progenitor cell therapy is being considered as a promising alternative with higher efficacy, but further research and development is necessary to overcome challenges and establish optimal treatment protocols.
Review
Cell Biology
Ning Zeng, Hongbo Chen, Yiping Wu, Zeming Liu
Summary: Wound healing in the human body is a complex physiological regulation mechanism, with adipose stem cells playing an important role in regenerative medicine. Adipose stem cells are easy to obtain, high-yielding, rich in components and cytokines, and highly practical.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Oncology
Alvaro Moreira, Lucie Heinzerling, Nina Bhardwaj, Philip Friedlander
Summary: This manuscript discusses recent updates on melanoma-related clinical trial data, including new therapeutic agents, long-term efficacy and safety data, breakthroughs related to management after resistance, and clinical trials for non-cutaneous melanoma. Groundbreaking research in immunology and cancer biology has led to the development of novel therapeutics, revolutionizing the clinical care of patients with metastatic melanoma.
Review
Biochemistry & Molecular Biology
Celia Bonilla, Mercedes Zurita
Summary: Traumatic brain injury (TBI) causes physical damage to brain tissue leading to neurological disabilities, and research on using stem cells to treat TBI is increasing.
Editorial Material
Biochemistry & Molecular Biology
Flaminia Kaluthantrige Don, Meritxell Huch
Summary: Organoid cultures are promising for both basic and clinical research, with potential breakthroughs, but are currently facing bottlenecks that hinder their full exploitation.
TRENDS IN MOLECULAR MEDICINE
(2021)
Article
Cell Biology
Gloria Bonuccelli, Federica Sotgia, Michael P. Lisanti
Summary: This study reports the identification of key compounds that can effectively inhibit the growth and propagation of cancer stem cells in MCF7 cells. These compounds can be categorized into different groups and can reprogram the metabolic phenotype of breast cancer cells to halt their propagation. These findings provide important clues for the development of new strategies to treat cancer stem cells.
Article
Biochemistry & Molecular Biology
Martina Cremona, Giulio Rusconi, Alessandro Ferrario, Luca Mariotta, Mauro Gola, Gianni Soldati
Summary: Stromal vascular fraction cells, along with adipose-derived mesenchymal stem cells, are widely used in clinical applications. Standardizing GMP processes and studying the variability of cell parameters are necessary for advanced cell therapy products. The results show that when laboratory protocols are standardized, the variability of quantifiable cell parameters is statistically non-significant.
Review
Biochemistry & Molecular Biology
Ioanna Lazana
Summary: Transplant-associated thrombotic microangiopathy (TA-TMA) is a significant contributor to morbidity and mortality after allogenic hematopoietic stem cell transplantation (allo-HSCT). The diagnosis of TA-TMA is challenging due to lack of consensus diagnostic criteria and common clinical features mimicking other diseases. Therapeutic plasma exchange (TPE) has been traditionally used, but the efficacy is doubtful. Complement inhibitors, such as eculizumab, have shown promising results in clinical trials. Future goals include identifying specific risk factors and developing better treatment options.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Qi-song Su, Dong-Lin Zhuang, Moussa Ide Nasser, Xiyalatu Sai, Gang Deng, Ge Li, Ping Zhu
Summary: Ischemic damage to the central nervous system is a severe complication of cardiovascular surgery, and there is currently no effective treatment available. Stem cell therapy offers a promising approach for the treatment of severe CNS ischemia-reperfusion injury.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Review
Medicine, General & Internal
Mehmet Murat Seval, Kazibe Koyuncu
Summary: Stem cells have the potential to be used in regenerative medicine for treating lower urinary tract dysfunction and stress urinary incontinence. However, further research and validation are needed for clinical applications of stem cell therapy.
FRONTIERS IN MEDICINE
(2022)
Article
Clinical Neurology
Monica Moreno, Chelsea R. Kline, Kerry Lanigan, Beth Kallmyer, Kristen Clifford, Sam Fazio
Summary: With the emergence of new clinical trial data on disease-modifying therapies in Alzheimer's disease (AD) studies, the Alzheimer's Association sought the perspectives of individuals living with AD on significance and new treatments. Thirty members of the Alzheimer's Association's National Early Stage Advisory Group participated in a focus group or online survey to gain insights on their desires for a groundbreaking treatment that could halt the progression of their disease at an early stage. Participants emphasized the importance of considering personal significance in addition to clinical significance and highlighted the need for accessibility, education, choice, and affordability moving forward.
ALZHEIMERS & DEMENTIA
(2023)
Review
Cell Biology
Simon Reider, Lukas Binder, Stefan Fuerst, Stefan Hatzl, Andreas Blesl
Summary: HSCT plays an important role in the treatment of Crohn's disease, serving as a reasonable treatment option for refractory patients, with significant impact on clinical efficacy and treatment complications.
Editorial Material
Biochemistry & Molecular Biology
Bishal Gyawali, Christopher M. Booth
Summary: Many newly approved cancer therapeutics have limited clinical benefits but are still prescribed. A common-sense revolution in oncology would prioritize treatments that meaningfully improve survival and quality of life.
