Translational repression of the Drosophila nanos mRNA involves the RNA helicase Belle and RNA coating by Me31B and Trailer hitch

ATP is dispensable for both miRNA- and Smaug-mediated deadenylation reactions

(2017) Sho Niinuma et al.   RNA

An N-end rule pathway that recognizes proline and destroys gluconeogenic enzymes

(2017) Shun-Jia Chen et al.   SCIENCE

miRISC and the CCR4–NOT complex silence mRNA targets independently of 43S ribosomal scanning

(2016) Duygu Kuzuoğlu‐Öztürk et al.   EMBO JOURNAL

The DDX6–4E-T interaction mediates translational repression and P-body assembly

(2016) Anastasiia Kamenska et al.   NUCLEIC ACIDS RESEARCH

Oligoadenylation of 3′ decay intermediates promotes cytoplasmic mRNA degradation inDrosophilacells

(2016) Christiane Harnisch et al.   RNA

P-body assembly requires DDX6 repression complexes rather than decay or Ataxin2/2L complexes

(2015) Jessica Ayache et al.   MOLECULAR BIOLOGY OF THE CELL

Independent and coordinate trafficking of single Drosophila germ plasm mRNAs

(2015) Shawn C. Little et al.   NATURE CELL BIOLOGY

XenopusCAF1 requires NOT1-mediated interaction with 4E-T to repress translation in vivo

(2015) Shruti Waghray et al.   RNA

Drosophila germ granules are structured and contain homotypic mRNA clusters

(2015) Tatjana Trcek et al.   Nature Communications

Aubergine iCLIP Reveals piRNA-Dependent Decay of mRNAs Involved in Germ Cell Development in the Early Embryo

(2015) Bridlin Barckmann et al.   Cell Reports

Structure of a Human 4E-T/DDX6/CNOT1 Complex Reveals the Different Interplay of DDX6-Binding Proteins with the CCR4-NOT Complex

(2015) Sevim Ozgur et al.   Cell Reports

The eIF4E-Binding Protein 4E-T Is a Component of the mRNA Decay Machinery that Bridges the 5′ and 3′ Termini of Target mRNAs

(2015) Tamiko Nishimura et al.   Cell Reports

Mitochondrial Dysfunction Reveals the Role of mRNA Poly(A) Tail Regulation in Oculopharyngeal Muscular Dystrophy Pathogenesis

(2015) Aymeric Chartier et al.   PLoS Genetics

The Ded1/DDX3 subfamily of DEAD-box RNA helicases

(2014) Deepak Sharma et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Automated Assignment of MS/MS Cleavable Cross-Links in Protein 3D-Structure Analysis

(2014) Michael Götze et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

A DDX6-CNOT1 Complex and W-Binding Pockets in CNOT9 Reveal Direct Links between miRNA Target Recognition and Silencing

(2014) Ying Chen et al.   MOLECULAR CELL

Structural and Biochemical Insights to the Role of the CCR4-NOT Complex and DDX6 ATPase in MicroRNA Repression

(2014) Hansruedi Mathys et al.   MOLECULAR CELL

Human DDX6 effects miRNA-mediated gene silencing via direct binding to CNOT1

(2014) Christopher Rouya et al.   RNA

Global regulation of mRNA translation and stability in the early Drosophila embryo by the Smaug RNA-binding protein

(2014) Linan Chen et al.   GENOME BIOLOGY

DEAD-Box Helicases Form Nucleotide-Dependent, Long-Lived Complexes with RNA

(2013) Fei Liu et al.   BIOCHEMISTRY

Control of maternal mRNA stability in germ cells and early embryos

(2013) Bridlin Barckmann et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Translation Repressors, an RNA Helicase, and Developmental Cues Control RNP Phase Transitions during Early Development

(2013) Arnaud Hubstenberger et al.   DEVELOPMENTAL CELL

The role of disordered protein regions in the assembly of decapping complexes and RNP granules

(2013) S. Jonas et al.   GENES & DEVELOPMENT

Human 4E-T represses translation of bound mRNAs and enhances microRNA-mediated silencing

(2013) A. Kamenska et al.   NUCLEIC ACIDS RESEARCH

Structural analysis of the yeast Dhh1–Pat1 complex reveals how Dhh1 engages Pat1, Edc3 and RNA in mutually exclusive interactions

(2013) Humayun Sharif et al.   NUCLEIC ACIDS RESEARCH

Molecular Phylogeny of a RING E3 Ubiquitin Ligase, Conserved in Eukaryotic Cells and Dominated by Homologous Components, the Muskelin/RanBPM/CTLH Complex

(2013) Ore Francis et al.   PLoS One

An Essential Role for Zygotic Expression in the Pre-Cellular Drosophila Embryo

(2013) Zehra Ali-Murthy et al.   PLoS Genetics

The role of the DEAD-box RNA helicase DDX3 in mRNA metabolism

(2013) Ricardo Soto-Rifo et al.   Wiley Interdisciplinary Reviews-RNA

microRNA-independent recruitment of Argonaute 1 to nanos mRNA through the Smaug RNA-binding protein

(2012) Benjamin D Pinder et al.   EMBO REPORTS

Crystal structure of a minimal eIF4E-Cup complex reveals a general mechanism of eIF4E regulation in translational repression

(2012) K. Kinkelin et al.   RNA

Multiple binding of repressed mRNAs by the P-body protein Rck/p54

(2012) M. Ernoult-Lange et al.   RNA

Translational Control by the DEAD Box RNA Helicase belle Regulates Ecdysone-Triggered Transcriptional Cascades

(2012) Robert J. Ihry et al.   PLoS Genetics

CUP promotes deadenylation and inhibits decapping of mRNA targets

(2011) C. Igreja et al.   GENES & DEVELOPMENT

Intermolecular Interactions within the Abundant DEAD-box Protein Dhh1 Regulate Its Activityin Vivo

(2011) Arnob Dutta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GW182 Proteins Directly Recruit Cytoplasmic Deadenylase Complexes to miRNA Targets

(2011) Joerg E. Braun et al.   MOLECULAR CELL

miRNA repression involves GW182-mediated recruitment of CCR4–NOT through conserved W-containing motifs

(2011) Marina Chekulaeva et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Diauxic shift-dependent relocalization of decapping activators Dhh1 and Pat1 to polysomal complexes

(2011) Sheona P. Drummond et al.   NUCLEIC ACIDS RESEARCH

Patterning of the Drosophila oocyte by a sequential translation repression program involving the d4EHP and Belle translational repressors

(2011) Alexander Yarunin et al.   RNA Biology

Posttranscriptional regulation in Drosophila oocytes and early embryos

(2011) Paul Lasko   Wiley Interdisciplinary Reviews-RNA

Cleavable Cross-Linker for Protein Structure Analysis: Reliable Identification of Cross-Linking Products by Tandem MS

(2010) Mathias Q. Müller et al.   ANALYTICAL CHEMISTRY

Smaug assembles an ATP-dependent stable complex repressingnanosmRNA translation at multiple levels

(2010) Mandy Jeske et al.   EMBO JOURNAL

Translational Repression by Deadenylases

(2010) Amy Cooke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HPat provides a link between deadenylation and decapping in metazoa

(2010) Gabrielle Haas et al.   JOURNAL OF CELL BIOLOGY

Decapping Activators in Saccharomyces cerevisiae Act by Multiple Mechanisms

(2010) Tracy Nissan et al.   MOLECULAR CELL

Maternal mRNA deadenylation and decay by the piRNA pathway in the early Drosophila embryo

(2010) Christel Rouget et al.   NATURE

An essential role for the RNA-binding protein Smaug during the Drosophila maternal-to-zygotic transition

(2009) B. Benoit et al.   DEVELOPMENT

Drosophila PTB promotes formation of high-order RNP particles and represses oskar translation

(2009) F. Besse et al.   GENES & DEVELOPMENT

In VivoStable Isotope Labeling of Fruit Flies Reveals Post-transcriptional Regulation in the Maternal-to-zygotic Transition

(2009) Joost W. Gouw et al.   MOLECULAR & CELLULAR PROTEOMICS

The SXL-UNR Corepressor Complex Uses a PABP-Mediated Mechanism to Inhibit Ribosome Recruitment to msl-2 mRNA

(2009) Kent E. Duncan et al.   MOLECULAR CELL

Structural Basis for the Mutually Exclusive Anchoring of P Body Components EDC3 and Tral to the DEAD Box Protein DDX6/Me31B

(2009) Felix Tritschler et al.   MOLECULAR CELL

Similar Modes of Interaction Enable Trailer Hitch and EDC3 To Associate with DCP1 and Me31B in Distinct Protein Complexes

(2008) F. Tritschler et al.   MOLECULAR AND CELLULAR BIOLOGY

The Yeast GID Complex, a Novel Ubiquitin Ligase (E3) Involved in the Regulation of Carbohydrate Metabolism

(2008) Olivier Santt et al.   MOLECULAR BIOLOGY OF THE CELL

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

Mechanism of ATP turnover inhibition in the EJC

(2008) K. H. Nielsen et al.   RNA

The DEAD-Box RNA Helicase Ded1p Affects and Accumulates in Saccharomyces cerevisiae P-Bodies

(2007) Carla Beckham et al.   MOLECULAR BIOLOGY OF THE CELL