Journal
MOLECULAR IMMUNOLOGY
Volume 68, Issue 2, Pages 112-115Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.molimm.2015.05.002
Keywords
ERAD; Cross-presentation; Dendritic cells; MHC; Antigen processing
Categories
Funding
- NIAID NIH HHS [R01-AI097206] Funding Source: Medline
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A long unanswered question in the antigen presentation field is how exogenous antigens cross-presented by Major Histocompatibility Complex class I (MHC-I) molecules to CD8(+) T cells are translocated into the cytosol. Here we discuss the known mechanisms involved in this process with a focus on the hypothesized role of the machinery that functions in endoplasmic reticulum-associated degradation (ERAD). Other potential mechanisms of antigen entry to the cytosol are also discussed. (C) 2015 Elsevier Ltd. All rights reserved.
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