Interleukin 37 reverses the metabolic cost of inflammation, increases oxidative respiration, and improves exercise tolerance

Suppression of innate inflammation and immunity by interleukin-37

(2016) Charles A. Dinarello et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Treating experimental arthritis with the innate immune inhibitor interleukin-37 reduces joint and systemic inflammation

(2016) Giulio Cavalli et al.   RHEUMATOLOGY

Regulatory Role of IL-1R8 in Immunity and Disease

(2016) Martina Molgora et al.   Frontiers in Immunology

IL-37 requires IL-18Rα and SIGIRR/IL-1R8 to diminish allergic airway inflammation in mice

(2015) L. Lunding et al.   ALLERGY

Treating Pulmonary Silicosis by Blocking Interleukin 1

(2015) Giulio Cavalli et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The AMP-activated protein kinase (AMPK) and cancer: Many faces of a metabolic regulator

(2015) Brandon Faubert et al.   CANCER LETTERS

IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction

(2015) Claudia A Nold-Petry et al.   NATURE IMMUNOLOGY

Treating rheumatological diseases and co-morbidities with interleukin-1 blocking therapies

(2015) Giulio Cavalli et al.   RHEUMATOLOGY

Efficacy and safety of biological agents in adult-onset Still’s disease

(2015) G Cavalli et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

Red blood cell storage in additive solution-7 preserves energy and redox metabolism: a metabolomics approach

(2015) Angelo D'Alessandro et al.   TRANSFUSION

Battery of behavioral tests in mice that models age-associated changes in human motor function

(2014) Jamie N. Justice et al.   AGE

IL-37 protects against obesity-induced inflammation and insulin resistance

(2014) Dov B. Ballak et al.   Nature Communications

IL-37 Inhibits Inflammasome Activation and Disease Severity in Murine Aspergillosis

(2014) Silvia Moretti et al.   PLoS Pathogens

Skeletal Muscle MnSOD, Mitochondrial Complex II, and SIRT3 Enzyme Activities Are Decreased in Maternal Obesity During Human Pregnancy and Gestational Diabetes Mellitus

(2013) Kristen E. Boyle et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Metabolism of inflammation limited by AMPK and pseudo-starvation

(2013) Luke A. J. O'Neill et al.   NATURE

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Succinate: a metabolic signal in inflammation

(2013) Evanna Mills et al.   TRENDS IN CELL BIOLOGY

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Compound C independent of AMPK inhibits ICAM-1 and VCAM-1 expression in inflammatory stimulants-activated endothelial cells in vitro and in vivo

(2011) Young Min Kim et al.   ATHEROSCLEROSIS

AMP-activated protein kinase--an energy sensor that regulates all aspects of cell function

(2011) D. G. Hardie   GENES & DEVELOPMENT

Training-induced adaptation in purine metabolism in high-level sprinters vs. triathletes

(2011) Jacek Zieliński et al.   JOURNAL OF APPLIED PHYSIOLOGY

Muscle metabolism and performance improvement after two training programmes of sprint running differing in rest interval duration

(2011) Ploutarchos Saraslanidis et al.   JOURNAL OF SPORTS SCIENCES

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

(2011) Maria M. Mihaylova et al.   NATURE CELL BIOLOGY

Interleukin 37 expression protects mice from colitis

(2011) E. N. McNamee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-37 is a fundamental inhibitor of innate immunity

(2010) Marcel F Nold et al.   NATURE IMMUNOLOGY

Exercise-Induced Oxidative Stress: Cellular Mechanisms and Impact on Muscle Force Production

(2008) Scott K. Powers et al.   PHYSIOLOGICAL REVIEWS

Destabilization of the Dystrophin-Glycoprotein Complex without Functional Deficits in α-Dystrobrevin Null Muscle

(2008) Tina M. Bunnell et al.   PLoS One

From inflammation to sickness and depression: when the immune system subjugates the brain

(2007) Robert Dantzer et al.   NATURE REVIEWS NEUROSCIENCE