Illuminating cell signalling with optogenetic tools

Signal amplification and transduction in phytochrome photosensors

(2014) Heikki Takala et al.   NATURE

An optogenetic gene expression system with rapid activation and deactivation kinetics

(2014) Laura B Motta-Mena et al.   Nature Chemical Biology

Reversible protein inactivation by optogenetic trapping in cells

(2014) Sangkyu Lee et al.   NATURE METHODS

Light-Mediated Kinetic Control Reveals the Temporal Effect of the Raf/MEK/ERK Pathway in PC12 Cell Neurite Outgrowth

(2014) Kai Zhang et al.   PLoS One

General Method for Regulating Protein Stability with Light

(2013) Kimberly M. Bonger et al.   ACS Chemical Biology

The p53 response in single cells is linearly correlated to the number of DNA breaks without a distinct threshold

(2013) Alexander Loewer et al.   BMC BIOLOGY

Using Optogenetics to Interrogate the Dynamic Control of Signal Transmission by the Ras/Erk Module

(2013) Jared E. Toettcher et al.   CELL

Encoding and Decoding Cellular Information through Signaling Dynamics

(2013) Jeremy E. Purvis et al.   CELL

Light-inducible activation of target mRNA translation in mammalian cells

(2013) Jicong Cao et al.   CHEMICAL COMMUNICATIONS

Synthesis of phycocyanobilin in mammalian cells

(2013) Konrad Müller et al.   CHEMICAL COMMUNICATIONS

A LOV2 Domain-Based Optogenetic Tool to Control Protein Degradation and Cellular Function

(2013) Christian Renicke et al.   CHEMISTRY & BIOLOGY

An optogenetic tool for the activation of endogenous diaphanous-related formins induces thickening of stress fibers without an increase in contractility

(2013) Megha Vaman Rao et al.   Cytoskeleton

A light-triggered protein secretion system

(2013) Daniel Chen et al.   JOURNAL OF CELL BIOLOGY

A light-inducible organelle-targeting system for dynamically activating and inactivating signaling in budding yeast

(2013) Xiaojing Yang et al.   MOLECULAR BIOLOGY OF THE CELL

Optogenetic protein clustering and signaling activation in mammalian cells

(2013) Lukasz J Bugaj et al.   NATURE METHODS

Phosphorylation of Phytochrome B Inhibits Light-Induced Signaling via Accelerated Dark Reversion in Arabidopsis

(2013) M. Medzihradszky et al.   PLANT CELL

Optical control demonstrates switch-like PIP3 dynamics underlying the initiation of immune cell migration

(2013) W. K. A. Karunarathne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ultraviolet-B-mediated induction of protein–protein interactions in mammalian cells

(2013) Remco P. Crefcoeur et al.   Nature Communications

Optogenetic Control of Protein Kinase Activity in Mammalian Cells

(2013) Sabrina Wend et al.   ACS Synthetic Biology

Designing Photoswitchable Peptides Using the AsLOV2 Domain

(2012) Oana I. Lungu et al.   CHEMISTRY & BIOLOGY

Light-dependent, Dark-promoted Interaction betweenArabidopsisCryptochrome 1 and Phytochrome B Proteins

(2012) Robert M. Hughes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TULIPs: tunable, light-controlled interacting protein tags for cell biology

(2012) Devin Strickland et al.   NATURE METHODS

Spatiotemporal control of gene expression by a light-switchable transgene system

(2012) Xue Wang et al.   NATURE METHODS

Optogenetic control of phosphoinositide metabolism

(2012) O. Idevall-Hagren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p53 Dynamics Control Cell Fate

(2012) J. E. Purvis et al.   SCIENCE

Optical Control of Protein Activity by Fluorescent Protein Domains

(2012) X. X. Zhou et al.   SCIENCE

The Development and Application of Optogenetics

(2011) Lief Fenno et al.   Annual Review of Neuroscience

Light-based feedback for controlling intracellular signaling dynamics

(2011) Jared E Toettcher et al.   NATURE METHODS

Dynamics of Dpp Signaling and Proliferation Control

(2011) O. Wartlick et al.   SCIENCE

Differential Regulation of Protrusion and Polarity by PI(3)K during Neutrophil Motility in Live Zebrafish

(2010) Sa Kan Yoo et al.   DEVELOPMENTAL CELL

Natural and Engineered Photoactivated Nucleotidyl Cyclases for Optogenetic Applications

(2010) Min-Hyung Ryu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Light Modulation of Cellular cAMP by a Small Bacterial Photoactivated Adenylyl Cyclase, bPAC, of the Soil BacteriumBeggiatoa

(2010) Manuela Stierl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A modular gradient-sensing network for chemotaxis in Escherichia coli revealed by responses to time-varying stimuli

(2010) Thomas S Shimizu et al.   Molecular Systems Biology

Light-mediated activation reveals a key role for Rac in collective guidance of cell movement in vivo

(2010) Xiaobo Wang et al.   NATURE CELL BIOLOGY

Rapid blue-light–mediated induction of protein interactions in living cells

(2010) Matthew J Kennedy et al.   NATURE METHODS

Rationally improving LOV domain–based photoswitches

(2010) Devin Strickland et al.   NATURE METHODS

Optogenetic Control of Cardiac Function

(2010) A. B. Arrenberg et al.   SCIENCE

The Incoherent Feedforward Loop Can Provide Fold-Change Detection in Gene Regulation

(2009) Lea Goentoro et al.   MOLECULAR CELL

Spatiotemporal control of cell signalling using a light-switchable protein interaction

(2009) Anselm Levskaya et al.   NATURE

Temporally precise in vivo control of intracellular signalling

(2009) Raag D. Airan et al.   NATURE

Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis

(2009) Sabrina L. Spencer et al.   NATURE

A genetically encoded photoactivatable Rac controls the motility of living cells

(2009) Yi I. Wu et al.   NATURE

Induction of protein-protein interactions in live cells using light

(2009) Masayuki Yazawa et al.   NATURE BIOTECHNOLOGY

Phasic Firing in Dopaminergic Neurons Is Sufficient for Behavioral Conditioning

(2009) H.-C. Tsai et al.   SCIENCE

Genetically encoded photoswitching of actin assembly through the Cdc42-WASP-Arp2/3 complex pathway

(2008) D. W. Leung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Photoexcited CRY2 Interacts with CIB1 to Regulate Transcription and Floral Initiation in Arabidopsis

(2008) H. Liu et al.   SCIENCE