Development and validation of a high-throughput transcriptomic biomarker to address 21st century genetic toxicology needs

The TGx-28.65 biomarker online application for analysis of transcriptomics data to identify DNA damage-inducing chemicals in human cell cultures

(2017) Marcus A. Jackson et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Integration of the TGx-28.65 genomic biomarker with the flow cytometry micronucleus test to assess the genotoxicity of disperse orange and 1,2,4-benzenetriol in human TK6 cells

(2017) Julie K. Buick et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Application of the TGx-28.65 transcriptomic biomarker to classify genotoxic and non-genotoxic chemicals in human TK6 cells in the presence of rat liver S9

(2016) Carole L. Yauk et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Approaches for characterizing threshold dose–response relationships for DNA-damage pathways involved in carcinogenicityin vivoand micronuclei formationin vitro

(2016) Rebecca A. Clewell et al.   MUTAGENESIS

Comparison of toxicogenomics and traditional approaches to inform mode of action and points of departure in human health risk assessment of benzo[a]pyrene in drinking water

(2015) Ivy Moffat et al.   CRITICAL REVIEWS IN TOXICOLOGY

Integration of metabolic activation with a predictive toxicogenomics signature to classify genotoxic versus nongenotoxic chemicals in human TK6 cells

(2015) Julie K. Buick et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Development of a toxicogenomics signature for genotoxicity using a dose-optimization and informatics strategy in human cells

(2015) Heng-Hong Li et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Transcriptomic responses generated by hepatocarcinogens in a battery of liver-based in vitro models

(2013) Tatyana Y. Doktorova et al.   CARCINOGENESIS

Incorporating New Technologies Into Toxicity Testing and Risk Assessment: Moving From 21st Century Vision to a Data-Driven Framework

(2013) Russell S. Thomas et al.   TOXICOLOGICAL SCIENCES

Follow-up actions from positive results of in vitro genetic toxicity testing

(2010) Kerry L. Dearfield et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Voluntary exploratory data submissions to the US FDA and the EMA: experience and impact

(2010) Federico M. Goodsaid et al.   NATURE REVIEWS DRUG DISCOVERY

Human health safety evaluation of cosmetics in the EU: A legally imposed challenge to science

(2009) M. Pauwels et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Comparison of different methods for an accurate assessment of cytotoxicity in the in vitro micronucleus test

(2008) Michael D. Fellows et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Recommended lists of genotoxic and non-genotoxic chemicals for assessment of the performance of new or improved genotoxicity tests: A follow-up to an ECVAM workshop

(2008) David Kirkland et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Direct multiplexed measurement of gene expression with color-coded probe pairs

(2008) Gary K Geiss et al.   NATURE BIOTECHNOLOGY