Development of a toxicogenomics signature for genotoxicity using a dose-optimization and informatics strategy in human cells

On mapping the human toxome

(2014) Thomas Hartung   ALTEX-Alternatives to Animal Experimentation

Effect of Chemical Mutagens and Carcinogens on Gene Expression Profiles in Human TK6 Cells

(2012) Lode Godderis et al.   PLoS One

Integrating transcriptomics and metabonomics to unravel modes-of-action of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in HepG2 cells

(2011) Danyel Jennen et al.   BMC Systems Biology

Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells

(2011) C. Magkoufopoulou et al.   MUTAGENESIS

Utilizing toxicogenomic data to understand chemical mechanism of action in risk assessment

(2011) Vickie S. Wilson et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

New and emerging technologies for genetic toxicity testing

(2010) Anthony M. Lynch et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Voluntary exploratory data submissions to the US FDA and the EMA: experience and impact

(2010) Federico M. Goodsaid et al.   NATURE REVIEWS DRUG DISCOVERY

Use of transcriptomics in understanding mechanisms of drug-induced toxicity

(2010) Yuxia Cui et al.   PHARMACOGENOMICS

Characterization and Interlaboratory Comparison of a Gene Expression Signature for Differentiating Genotoxic Mechanisms

(2009) Heidrun Ellinger-Ziegelbauer et al.   TOXICOLOGICAL SCIENCES

Improving prediction of chemical carcinogenicity by considering multiple mechanisms and applying toxicogenomic approaches

(2008) Kathryn Z. Guyton et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Transcriptional control of human p53-regulated genes

(2008) Todd Riley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Genetic and Epigenetic Mechanisms in Metal Carcinogenesis and Cocarcinogenesis: Nickel, Arsenic, and Chromium

(2007) Konstantin Salnikow et al.   CHEMICAL RESEARCH IN TOXICOLOGY