Approaches for characterizing threshold dose–response relationships for DNA-damage pathways involved in carcinogenicityin vivoand micronuclei formationin vitro

Contributions of DNA repair and damage response pathways to the non-linear genotoxic responses of alkylating agents

(2016) Joanna Klapacz et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Adaptive Posttranslational Control in Cellular Stress Response Pathways and Its Relationship to Toxicity Testing and Safety Assessment

(2015) Qiang Zhang et al.   TOXICOLOGICAL SCIENCES

Formation, Accumulation, and Hydrolysis of Endogenous and Exogenous Formaldehyde-Induced DNA Damage

(2015) Rui Yu et al.   TOXICOLOGICAL SCIENCES

Implementing Toxicity Testing in the 21st Century (TT21C): Making safety decisions using toxicity pathways, and progress in a prototype risk assessment

(2015) Yeyejide Adeleye et al.   TOXICOLOGY

Profiling Dose-Dependent Activation of p53-Mediated Signaling Pathways by Chemicals with Distinct Mechanisms of DNA Damage

(2014) Rebecca A. Clewell et al.   TOXICOLOGICAL SCIENCES

Temporal Concordance Between Apical and Transcriptional Points of Departure for Chemical Risk Assessment

(2013) Russell S. Thomas et al.   TOXICOLOGICAL SCIENCES

Assessing dose-dependent differences in DNA-damage, p53 response and genotoxicity for quercetin and curcumin

(2013) Bin Sun et al.   TOXICOLOGY IN VITRO

Integrating pathway-based transcriptomic data into quantitative chemical risk assessment: A five chemical case study

(2012) Russell S. Thomas et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Toxicity Testing in the 21st Century: Defining New Risk Assessment Approaches Based on Perturbation of Intracellular Toxicity Pathways

(2011) Sudin Bhattacharya et al.   PLoS One

Evidence for formation of DNA repair centers and dose-response nonlinearity in human cells

(2011) T. Neumaier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Computational Systems Biology and Dose-Response Modeling in Relation to New Directions in Toxicity Testing

(2010) Qiang Zhang et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Formaldehyde: Integrating Dosimetry, Cytotoxicity, and Genomics to Understand Dose-Dependent Transitions for an Endogenous Compound

(2010) Melvin E. Andersen et al.   TOXICOLOGICAL SCIENCES

Endogenous versus Exogenous DNA Adducts: Their Role in Carcinogenesis, Epidemiology, and Risk Assessment

(2010) J. A. Swenberg et al.   TOXICOLOGICAL SCIENCES

Statistical model to estimate a threshold dose and its confidence limits for the analysis of sublinear dose–response relationships, exemplified for mutagenicity data

(2009) Werner K. Lutz et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Cellular Stress Response Pathway System as a Sentinel Ensemble in Toxicological Screening

(2009) Steven O. Simmons et al.   TOXICOLOGICAL SCIENCES

Genomic Signatures and Dose-Dependent Transitions in Nasal Epithelial Responses to Inhaled Formaldehyde in the Rat

(2008) Melvin E. Andersen et al.   TOXICOLOGICAL SCIENCES