Exploiting conformational plasticity in the AAA+ protein VCP/p97 to modify function
Published 2017 View Full Article
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Title
Exploiting conformational plasticity in the AAA+ protein VCP/p97 to modify function
Authors
Keywords
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Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 114, Issue 33, Pages E6822-E6829
Publisher
Proceedings of the National Academy of Sciences
Online
2017-08-01
DOI
10.1073/pnas.1707974114
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- The N-terminal Region of the Ubiquitin Regulatory X (UBX) Domain-containing Protein 1 (UBXD1) Modulates Interdomain Communication within the Valosin-containing Protein p97
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- VCP-dependent muscle degeneration is linked to defects in a dynamic tubular lysosomal network in vivo
- (2015) Alyssa E Johnson et al. eLife
- The VCP/p97 system at a glance: connecting cellular function to disease pathogenesis
- (2014) H. Meyer et al. JOURNAL OF CELL SCIENCE
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- The Role of the N-Domain in the ATPase Activity of the Mammalian AAA ATPase p97/VCP
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- Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system
- (2012) Hemmo Meyer et al. NATURE CELL BIOLOGY
- The General Definition of the p97/Valosin-containing Protein (VCP)-interacting Motif (VIM) Delineates a New Family of p97 Cofactors
- (2011) Christopher Stapf et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Structural and Functional Basis of the p97/Valosin-containing Protein (VCP)-interacting Motif (VIM)
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- Stereospecific Isotopic Labeling of Methyl Groups for NMR Spectroscopic Studies of High-Molecular-Weight Proteins
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- VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD
- (2010) Emilie Tresse et al. Autophagy
- A novel ATP-dependent conformation in p97 N–D1 fragment revealed by crystal structures of disease-related mutants
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- Role of conformational sampling in computing mutation-induced changes in protein structure and stability
- (2010) Elizabeth H. Kellogg et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
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