A Dynamic molecular basis for malfunction in disease mutants of p97/VCP

p97 Disease Mutations Modulate Nucleotide-Induced Conformation to Alter Protein–Protein Interactions

(2016) Stacie L. Bulfer et al.   ACS Chemical Biology

Origin and Functional Evolution of the Cdc48/p97/VCP AAA+ Protein Unfolding and Remodeling Machine

(2016) Dominik Barthelme et al.   JOURNAL OF MOLECULAR BIOLOGY

215th ENMC International Workshop VCP-related multi-system proteinopathy (IBMPFD) 13–15 November 2015, Heemskerk, The Netherlands

(2016) Teresinha Evangelista et al.   NEUROMUSCULAR DISORDERS

2.3 A resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition

(2016) S. Banerjee et al.   SCIENCE

Characterization of an Additional Binding Surface on the p97 N-Terminal Domain Involved in Bipartite Cofactor Interactions

(2016) Petra Hänzelmann et al.   STRUCTURE

Role of the D1-D2 Linker of Human VCP/p97 in the Asymmetry and ATPase Activity of the D1-domain

(2016) Wai Kwan Tang et al.   Scientific Reports

Targeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein Homeostasis

(2015) Daniel J. Anderson et al.   CANCER CELL

Control of p97 function by cofactor binding

(2015) Alexander Buchberger et al.   FEBS LETTERS

The N-terminal Region of the Ubiquitin Regulatory X (UBX) Domain-containing Protein 1 (UBXD1) Modulates Interdomain Communication within the Valosin-containing Protein p97

(2015) Franziska Trusch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Altered cofactor regulation with disease-associated p97/VCP mutations

(2015) Xiaoyi Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

VCP-dependent muscle degeneration is linked to defects in a dynamic tubular lysosomal network in vivo

(2015) Alyssa E Johnson et al.   eLife

Bringing Dynamic Molecular Machines into Focus by Methyl-TROSY NMR

(2014) Rina Rosenzweig et al.   Annual Review of Biochemistry

The VCP/p97 system at a glance: connecting cellular function to disease pathogenesis

(2014) H. Meyer et al.   JOURNAL OF CELL SCIENCE

Specific Inhibition of p97/VCP ATPase and Kinetic Analysis Demonstrate Interaction between D1 and D2 ATPase Domains

(2014) Tsui-Fen Chou et al.   JOURNAL OF MOLECULAR BIOLOGY

Tracing an allosteric pathway regulating the activity of the HslV protease

(2014) Lichi Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Architecture and assembly of the archaeal Cdc48*20S proteasome

(2014) D. Barthelme et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polyubiquitylation drives replisome disassembly at the termination of DNA replication

(2014) Sara Priego Moreno et al.   SCIENCE

Eukaryotic Stress Granules Are Cleared by Autophagy and Cdc48/VCP Function

(2013) J. Ross Buchan et al.   CELL

Altered Intersubunit Communication Is the Molecular Basis for Functional Defects of Pathogenic p97 Mutants

(2013) Wai Kwan Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genotype-phenotype studies of VCP-associated inclusion body myopathy with Paget disease of bone and/or frontotemporal dementia

(2012) SG Mehta et al.   CLINICAL GENETICS

The Role of the N-Domain in the ATPase Activity of the Mammalian AAA ATPase p97/VCP

(2012) Hajime Niwa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system

(2012) Hemmo Meyer et al.   NATURE CELL BIOLOGY

Proteasome allostery as a population shift between interchanging conformers

(2012) A. M. Ruschak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Growing sphere of influence: Cdc48/p97 orchestrates ubiquitin-dependent extraction from chromatin

(2012) Nico P. Dantuma et al.   TRENDS IN CELL BIOLOGY

Structure and function of the AAA+ nucleotide binding pocket

(2011) Petra Wendler et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The General Definition of the p97/Valosin-containing Protein (VCP)-interacting Motif (VIM) Delineates a New Family of p97 Cofactors

(2011) Christopher Stapf et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Structural and Functional Basis of the p97/Valosin-containing Protein (VCP)-interacting Motif (VIM)

(2011) Petra Hänzelmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Optimized Relaxation-Based Coherence Transfer NMR Experiment for the Measurement of Side-Chain Order in Methyl-Protonated, Highly Deuterated Proteins

(2011) Hechao Sun et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Endolysosomal sorting of ubiquitylated caveolin-1 is regulated by VCP and UBXD1 and impaired by VCP disease mutations

(2011) Danilo Ritz et al.   NATURE CELL BIOLOGY

Exome Sequencing Reveals VCP Mutations as a Cause of Familial ALS

(2011) Janel O. Johnson et al.   NEURON

Valosin-containing protein mutation and Parkinson’s disease

(2011) Nora Chan et al.   PARKINSONISM & RELATED DISORDERS

Hierarchical Binding of Cofactors to the AAA ATPase p97

(2011) Petra Hänzelmann et al.   STRUCTURE

VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD

(2010) Emilie Tresse et al.   Autophagy

A novel ATP-dependent conformation in p97 N–D1 fragment revealed by crystal structures of disease-related mutants

(2010) Wai Kwan Tang et al.   EMBO JOURNAL

Imbalances in p97 co-factor interactions in human proteinopathy

(2010) Vanesa Fernández-Sáiz et al.   EMBO REPORTS

Enhanced ATPase activities as a primary defect of mutant valosin-containing proteins that cause inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia

(2010) Atsushi Manno et al.   GENES TO CELLS

Role of conformational sampling in computing mutation-induced changes in protein structure and stability

(2010) Elizabeth H. Kellogg et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

UBXD1 is a VCP-interacting protein that is involved in ER-associated degradation

(2009) Masami Nagahama et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease

(2009) Jeong-Sun Ju et al.   JOURNAL OF CELL BIOLOGY

Ubxd1 is a novel co-factor of the human p97 ATPase

(2008) Louise Madsen et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY