The cellular prion protein (PrPC) as neuronal receptor for α-synuclein

Alpha-synuclein fibrils propagate through tunneling nanotubes

(2017) Shinya Okuda et al.   MOVEMENT DISORDERS

In vitro α-synuclein neurotoxicity and spreading among neurons and astrocytes using Lewy body extracts from Parkinson disease brains

(2017) Fabio Cavaliere et al.   NEUROBIOLOGY OF DISEASE

Prion-like mechanisms and potential therapeutic targets in neurodegenerative disorders

(2017) Masato Hasegawa et al.   PHARMACOLOGY & THERAPEUTICS

Cell Biology and Pathophysiology of α-Synuclein

(2017) Jacqueline Burré et al.   Cold Spring Harbor Perspectives in Medicine

The Biological Function of the Prion Protein: A Cell Surface Scaffold of Signaling Modules

(2017) Rafael Linden   Frontiers in Molecular Neuroscience

α-synuclein transfer through tunneling nanotubes occurs in SH-SY5Y cells and primary brain pericytes from Parkinson’s disease patients

(2017) Birger Victor Dieriks et al.   Scientific Reports

Like prions: the propagation of aggregated tau and α-synuclein in neurodegeneration

(2016) Michel Goedert et al.   BRAIN

Strictly co-isogenic C57BL/6J-Prnp−/−mice: A rigorous resource for prion science

(2016) Mario Nuvolone et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neuroinvasion of α-Synuclein Prionoids after Intraperitoneal and Intraglossal Inoculation

(2016) Sara Breid et al.   JOURNAL OF VIROLOGY

Functions of the cellular prion protein, the end of Moore's law, and Ockham's razor theory

(2016) José A. del Río et al.   Prion

Tunneling nanotubes: A possible highway in the spreading of tau and other prion-like proteins in neurodegenerative diseases

(2016) Saida Abounit et al.   Prion

Pathological  -synuclein transmission initiated by binding lymphocyte-activation gene 3

(2016) X. Mao et al.   SCIENCE

α-Synuclein and huntingtin exon 1 amyloid fibrils bind laterally to the cellular membrane

(2016) Elodie Monsellier et al.   Scientific Reports

Tunneling nanotube (TNT)-mediated neuron-to neuron transfer of pathological Tau protein assemblies

(2016) Meryem Tardivel et al.   Acta Neuropathologica Communications

Interaction of single and multi wall carbon nanotubes with the biological systems: tau protein and PC12 cells as targets

(2016) Hojjat Alizadeh Zeinabad et al.   Scientific Reports

Metabotropic glutamate receptor 5 couples cellular prion protein to intracellular signalling in Alzheimer’s disease

(2015) Laura T. Haas et al.   BRAIN

 -synuclein assemblies sequester neuronal  3-Na+/K+-ATPase and impair Na+ gradient

(2015) A. N. Shrivastava et al.   EMBO JOURNAL

Prion-Protein-interacting Amyloid-β Oligomers of High Molecular Weight Are Tightly Correlated with Memory Impairment in Multiple Alzheimer Mouse Models

(2015) Mikhail A. Kostylev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alzheimer's and Parkinson's diseases: The prion concept in relation to assembled A , tau, and  -synuclein

(2015) M. Goedert   SCIENCE

Prion-like propagation of human brain-derived alpha-synuclein in transgenic mice expressing human wild-type alpha-synuclein

(2015) Maria E. Bernis et al.   Acta Neuropathologica Communications

The cell biology of prion-like spread of protein aggregates: mechanisms and implication in neurodegeneration

(2015) Maddalena Costanzo et al.   BIOCHEMICAL JOURNAL

High molecular mass assemblies of amyloid-β oligomers bind prion protein in patients with Alzheimer’s disease

(2014) Frank Dohler et al.   BRAIN

Single-Molecule Imaging Reveals that Small Amyloid-β1-42Oligomers Interact with the Cellular Prion Protein (PrPC)

(2014) Kristina A. Ganzinger et al.   CHEMBIOCHEM

­Classifying prion and prion-like phenomena

(2014) Djamel Harbi et al.   Prion

Pathological alpha-synuclein propagates through neural networks

(2014) Masami Masuda-Suzukake et al.   Acta Neuropathologica Communications

β-Amyloid is transmitted via neuronal connections along axonal membranes

(2013) Ha-Lim Song et al.   ANNALS OF NEUROLOGY

Lewy body extracts from Parkinson disease brains trigger α-synuclein pathology and neurodegeneration in mice and monkeys

(2013) Ariadna Recasens et al.   ANNALS OF NEUROLOGY

An N-terminal Fragment of the Prion Protein Binds to Amyloid-β Oligomers and Inhibits Their Neurotoxicityin Vivo

(2013) Brian R. Fluharty et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neurotoxicity of Prion Peptides Mimicking the Central Domain of the Cellular Prion Protein

(2013) Silvia Vilches et al.   PLoS One

Prions, prionoids and pathogenic proteins in Alzheimer disease

(2013) Karen H. Ashe et al.   Prion

Neuron-to-neuron transmission of α-synuclein fibrils through axonal transport

(2012) Eric C. Freundt et al.   ANNALS OF NEUROLOGY

Soluble  -Synuclein Is a Novel Modulator of Alzheimer's Disease Pathophysiology

(2012) M. E. Larson et al.   JOURNAL OF NEUROSCIENCE

Pathological  -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

(2012) K. C. Luk et al.   SCIENCE

The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication

(2011) Ulrike K Resenberger et al.   EMBO JOURNAL

Amyloid-β42 Interacts Mainly with Insoluble Prion Protein in the Alzheimer Brain

(2011) Wen-Quan Zou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transmission of Prion Strains in a Transgenic Mouse Model Overexpressing Human A53T Mutated α-Synuclein

(2011) Anne-Laure J. Mougenot et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Cellular Prion Protein Mediates Toxic Signaling of Amyloid Beta

(2011) Ulrike K. Resenberger et al.   Neurodegenerative Diseases

Interaction between prion protein and toxic amyloid β assemblies can be therapeutically targeted at multiple sites

(2011) Darragh B. Freir et al.   Nature Communications

Anti-PrPC monoclonal antibody infusion as a novel treatment for cognitive deficits in an alzheimer's disease model mouse

(2010) Erika Chung et al.   BMC NEUROSCIENCE

Prion protein and Aβ-related synaptic toxicity impairment

(2010) Anna Maria Calella et al.   EMBO Molecular Medicine

Interaction between Human Prion Protein and Amyloid-β (Aβ) Oligomers

(2010) Shugui Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The prion protein as a receptor for amyloid-β

(2010) Helmut W. Kessels et al.   NATURE

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

(2009) Juha Laurén et al.   NATURE