The extracellular matrix and focal adhesion kinase signaling regulate cancer stem cell function in pancreatic ductal adenocarcinoma
Published 2017 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The extracellular matrix and focal adhesion kinase signaling regulate cancer stem cell function in pancreatic ductal adenocarcinoma
Authors
Keywords
Collagens, Cancer stem cells, Cancer treatment, Integrins, Metastasis, Kinase inhibitors, Cancer cell migration, Cell migration
Journal
PLoS One
Volume 12, Issue 7, Pages e0180181
Publisher
Public Library of Science (PLoS)
Online
2017-07-11
DOI
10.1371/journal.pone.0180181
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Anti-metastatic action of FAK inhibitor OXA-11 in combination with VEGFR-2 signaling blockade in pancreatic neuroendocrine tumors
- (2015) Ingrid Moen et al. CLINICAL & EXPERIMENTAL METASTASIS
- Desmoplasia in Primary Tumors and Metastatic Lesions of Pancreatic Cancer
- (2015) C. J. Whatcott et al. CLINICAL CANCER RESEARCH
- Microenvironmental hCAP-18/LL-37 promotes pancreatic ductal adenocarcinoma by activating its cancer stem cell compartment
- (2015) Bruno Sainz et al. GUT
- Stromal biology and therapy in pancreatic cancer: a changing paradigm
- (2015) Albrecht Neesse et al. GUT
- Three-Dimensional Collagen Type I Matrix Up-Regulates Nuclear Isoforms of the Microtubule Associated Protein Tau Implicated in Resistance to Paclitaxel Therapy in Ovarian Carcinoma
- (2015) Hilal Gurler et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Integrins and cancer: regulators of cancer stemness, metastasis, and drug resistance
- (2015) Laetitia Seguin et al. TRENDS IN CELL BIOLOGY
- The FAK scaffold inhibitor C4 disrupts FAK-VEGFR-3 signaling and inhibits pancreatic cancer growth
- (2015) Elena Kurenova et al. Oncotarget
- Pyk2 promotes tumor progression in multiple myeloma
- (2014) Y. Zhang et al. BLOOD
- Targeting the C-terminal focal adhesion kinase scaffold in pancreatic cancer
- (2014) Priyanka N. Gogate et al. CANCER LETTERS
- ISG15 Is a Critical Microenvironmental Factor for Pancreatic Cancer Stem Cells
- (2014) B. Sainz et al. CANCER RESEARCH
- Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States
- (2014) L. Rahib et al. CANCER RESEARCH
- A small molecule FAK kinase inhibitor, GSK2256098, inhibits growth and survival of pancreatic ductal adenocarcinoma cells
- (2014) Jianliang Zhang et al. CELL CYCLE
- Metastatic Stem Cells: Sources, Niches, and Vital Pathways
- (2014) Thordur Oskarsson et al. Cell Stem Cell
- Kindlin-1 controls Wnt and TGF-β availability to regulate cutaneous stem cell proliferation
- (2014) Emanuel Rognoni et al. NATURE MEDICINE
- Hematopoietic stem cell niche maintenance during homeostasis and regeneration
- (2014) Avital Mendelson et al. NATURE MEDICINE
- Merlin Deficiency Predicts FAK Inhibitor Sensitivity: A Synthetic Lethal Relationship
- (2014) I. M. Shapiro et al. Science Translational Medicine
- The cancer stem cell niche: cross talk between cancer stem cells and their microenvironment
- (2014) Jun Ye et al. TUMOR BIOLOGY
- Growth differentiating factor 15 enhances the tumor-initiating and self-renewal potential of multiple myeloma cells
- (2013) T. Tanno et al. BLOOD
- Pancreatic stellate cells promote hapto-migration of cancer cells through collagen I-mediated signalling pathway
- (2013) J Lu et al. BRITISH JOURNAL OF CANCER
- Distinct FAK Activities Determine Progenitor and Mammary Stem Cell Characteristics
- (2013) M. Luo et al. CANCER RESEARCH
- Deciphering the role of stroma in pancreatic cancer
- (2013) Meghna Waghray et al. CURRENT OPINION IN GASTROENTEROLOGY
- Therapeutic Advances in Pancreatic Cancer
- (2013) Andrew Scott Paulson et al. GASTROENTEROLOGY
- DCLK1 Marks a Morphologically Distinct Subpopulation of Cells With Stem Cell Properties in Preinvasive Pancreatic Cancer
- (2013) Jennifer M. Bailey et al. GASTROENTEROLOGY
- The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis
- (2013) Kun Zhang et al. NATURE CELL BIOLOGY
- Disrupting the Scaffold to Improve Focal Adhesion Kinase-Targeted Cancer Therapeutics
- (2013) W. G. Cance et al. Science Signaling
- Fibronectin extra domain A (EDA) sustains CD133+/CD44+ subpopulation of colorectal cancer cells
- (2013) Juanjuan Ou et al. Stem Cell Research
- Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma
- (2012) Paolo P. Provenzano et al. CANCER CELL
- Pancreatic stellate cells form a niche for cancer stem cells and promote their self-renewal and invasiveness
- (2012) Enza Lonardo et al. CELL CYCLE
- The Stem Cell Niche in Regenerative Medicine
- (2012) Amy J. Wagers Cell Stem Cell
- Integrin alpha2beta1 (α2β1) promotes prostate cancer skeletal metastasis
- (2012) Joseph L. Sottnik et al. CLINICAL & EXPERIMENTAL METASTASIS
- Heterogeneity and Targeting of Pancreatic Cancer Stem Cells
- (2012) V. R. Penchev et al. CLINICAL CANCER RESEARCH
- The Impact of the Activated Stroma on Pancreatic Ductal Adenocarcinoma Biology and Therapy Resistance
- (2012) Mert Erkan et al. CURRENT MOLECULAR MEDICINE
- Fibrillar Type I Collagen Matrices Enhance Metastasis/Invasion of Ovarian Epithelial Cancer Via β1 Integrin and PTEN Signals
- (2012) Yufei Shen et al. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
- Function of Focal Adhesion Kinase Scaffolding to Mediate Endophilin A2 Phosphorylation Promotes Epithelial-Mesenchymal Transition and Mammary Cancer Stem Cell Activitiesin Vivo
- (2012) Huaping Fan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Collagen I fiber density increases in lymph node positive breast cancers: pilot study
- (2012) Samata M. Kakkad et al. JOURNAL OF BIOMEDICAL OPTICS
- Safety, Pharmacokinetic, and Pharmacodynamic Phase I Dose-Escalation Trial of PF-00562271, an Inhibitor of Focal Adhesion Kinase, in Advanced Solid Tumors
- (2012) Jeffrey R. Infante et al. JOURNAL OF CLINICAL ONCOLOGY
- c-Met Is a Marker of Pancreatic Cancer Stem Cells and Therapeutic Target
- (2011) Chenwei Li et al. GASTROENTEROLOGY
- Knockdown of the β1 integrin subunit reduces primary tumor growth and inhibits pancreatic cancer metastasis
- (2011) John J. Grzesiak et al. INTERNATIONAL JOURNAL OF CANCER
- Inhibition of Focal Adhesion Kinase by PF-562,271 Inhibits the Growth and Metastasis of Pancreatic Cancer Concomitant with Altering the Tumor Microenvironment
- (2011) J. B. Stokes et al. MOLECULAR CANCER THERAPEUTICS
- Tumor-initiating stem cells of squamous cell carcinomas and their control by TGF- and integrin/focal adhesion kinase (FAK) signaling
- (2011) M. Schober et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Therapeutic potential and limitations of new FAK inhibitors in the treatment of cancer
- (2010) Alexander Schultze et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Prognostic Significance of Tumorigenic Cells With Mesenchymal Features in Pancreatic Adenocarcinoma
- (2010) Zeshaan A. Rasheed et al. JNCI-Journal of the National Cancer Institute
- A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24
- (2010) Ellen L Goode et al. NATURE GENETICS
- Type I collagen inhibits differentiation and promotes a stem cell-like phenotype in human colorectal carcinoma cells
- (2009) S C Kirkland BRITISH JOURNAL OF CANCER
- Integrins
- (2009) Malgorzata Barczyk et al. CELL AND TISSUE RESEARCH
- Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis
- (2009) Jane E. Visvader GENES & DEVELOPMENT
- ELDA: Extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays
- (2009) Yifang Hu et al. JOURNAL OF IMMUNOLOGICAL METHODS
- Intrinsic chemoresistance to gemcitabine is associated with constitutive and laminin-induced phosphorylation of FAK in pancreatic cancer cell lines
- (2009) Wu Huanwen et al. Molecular Cancer
- A direct pancreatic cancer xenograft model as a platform for cancer stem cell therapeutic development
- (2009) A. Jimeno et al. MOLECULAR CANCER THERAPEUTICS
- Module Map of Stem Cell Genes Guides Creation of Epithelial Cancer Stem Cells
- (2008) David J. Wong et al. Cell Stem Cell
- The Desmoplastic Reaction Surrounding Hepatic Colorectal Adenocarcinoma Metastases Aids Tumor Growth and Survival via v Integrin Ligation
- (2008) J. A. Conti et al. CLINICAL CANCER RESEARCH
- β1 Integrin deletion from the basal compartment of the mammary epithelium affects stem cells
- (2008) Ilaria Taddei et al. NATURE CELL BIOLOGY
- Cardiac developmental defects and eccentric right ventricular hypertrophy in cardiomyocyte focal adhesion kinase (FAK) conditional knockout mice
- (2008) X. Peng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search