Anti-metastatic action of FAK inhibitor OXA-11 in combination with VEGFR-2 signaling blockade in pancreatic neuroendocrine tumors

Focal adhesion kinase

(2014) Rebecca L Stone et al.   CANCER BIOLOGY & THERAPY

FERM control of FAK function: Implications for cancer therapy

(2014) Ssang-Taek Lim et al.   CELL CYCLE

Design, synthesis, and biological evaluation of novel FAK scaffold inhibitors targeting the FAK–VEGFR3 protein–protein interaction

(2014) Priyanka N. Gogate et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Targeting FAK in human cancer: from finding to first clinical trials

(2014) Vita Golubovskaya   Frontiers in Bioscience-Landmark

Analyses of merlin/NF2 connection to FAK inhibitor responsiveness in serous ovarian cancer

(2014) Nina R. Shah et al.   GYNECOLOGIC ONCOLOGY

Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function

(2014) Christine Jean et al.   JOURNAL OF CELL BIOLOGY

Endothelial-cell FAK targeting sensitizes tumours to DNA-damaging therapy

(2014) Bernardo Tavora et al.   NATURE

Targeted Inhibition of FAK, PYK2 and BCL-XL Synergistically Enhances Apoptosis in Ovarian Clear Cell Carcinoma Cell Lines

(2014) Heejei Yoon et al.   PLoS One

Ramucirumab: preclinical research and clinical development

(2014) Giuseppe Aprile et al.   OncoTargets and Therapy

Aflibercept—a Decoy VEGF Receptor

(2014) Kristen K. Ciombor et al.   Current Oncology Reports

Inhibition of c-Met Reduces Lymphatic Metastasis in RIP-Tag2 Transgenic Mice

(2013) B. Sennino et al.   CANCER RESEARCH

Vessel co-option in primary human tumors and metastases: an obstacle to effective anti-angiogenic treatment?

(2013) Tom Donnem et al.   Cancer Medicine

A small molecule focal adhesion kinase (FAK) inhibitor, targeting Y397 site: 1-(2-hydroxyethyl) -3, 5, 7-triaza-1-azoniatricyclo [3.3.1.13,7]decane; bromide effectively inhibits FAK autophosphorylation activity and decreases cancer cell viability, clonogenicity and tumor growth in vivo

(2012) V. M. Golubovskaya et al.   CARCINOGENESIS

Inhibition of focal adhesion kinase (FAK) activity prevents anchorage-independent ovarian carcinoma cell growth and tumor progression

(2012) Kristy K. Ward et al.   CLINICAL & EXPERIMENTAL METASTASIS

VEGF-Induced Vascular Permeability Is Mediated by FAK

(2012) Xiao Lei Chen et al.   DEVELOPMENTAL CELL

Semaphorin 3A overcomes cancer hypoxia and metastatic dissemination induced by antiangiogenic treatment in mice

(2012) Federica Maione et al.   JOURNAL OF CLINICAL INVESTIGATION

Pharmacologic Blockade of FAK Autophosphorylation Decreases Human Glioblastoma Tumor Growth and Synergizes with Temozolomide

(2012) V. M. Golubovskaya et al.   MOLECULAR CANCER THERAPEUTICS

Anti-tumor effect of a novel FAK inhibitor TAE226 against human oral squamous cell carcinoma

(2012) Naito Kurio et al.   ORAL ONCOLOGY

Suppression of Tumor Invasion and Metastasis by Concurrent Inhibition of c-Met and VEGF Signaling in Pancreatic Neuroendocrine Tumors

(2012) Barbara Sennino et al.   Cancer Discovery

Reduced VEGF Production, Angiogenesis, and Vascular Regrowth Contribute to the Antitumor Properties of Dual mTORC1/mTORC2 Inhibitors

(2011) B. L. Falcon et al.   CANCER RESEARCH

Distinct contributions of angiogenesis and vascular co-option during the initiation of primary microtumors and micrometastases

(2011) Chengjian Zhao et al.   CARCINOGENESIS

Focal adhesion kinase and tumour angiogenesis

(2011) Tanguy Lechertier et al.   JOURNAL OF PATHOLOGY

Inhibition of Focal Adhesion Kinase by PF-562,271 Inhibits the Growth and Metastasis of Pancreatic Cancer Concomitant with Altering the Tumor Microenvironment

(2011) J. B. Stokes et al.   MOLECULAR CANCER THERAPEUTICS

Sunitinib and PF-562,271 (FAK/Pyk2 inhibitor) effectively block growth and recovery of human hepatocellular carcinoma in a rat xenograft model

(2010) Cedo M Bagi et al.   CANCER BIOLOGY & THERAPY

Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models

(2010) Colin Walsh et al.   CANCER BIOLOGY & THERAPY

Endothelial FAK is required for tumour angiogenesis

(2010) Bernardo Tavora et al.   EMBO Molecular Medicine

Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions

(2010) M. D. Schaller   JOURNAL OF CELL SCIENCE

Accelerated Metastasis after Short-Term Treatment with a Potent Inhibitor of Tumor Angiogenesis

(2009) John M.L. Ebos et al.   CANCER CELL

Antiangiogenic Therapy Elicits Malignant Progression of Tumors to Increased Local Invasion and Distant Metastasis

(2009) Marta Pàez-Ribes et al.   CANCER CELL

Dual focal adhesion kinase/Pyk2 inhibitor has positive effects on bone tumors

(2008) Cedo M. Bagi et al.   CANCER

Antitumor Activity and Pharmacology of a Selective Focal Adhesion Kinase Inhibitor, PF-562,271

(2008) W. G. Roberts et al.   CANCER RESEARCH

Src and focal adhesion kinase as therapeutic targets in cancer

(2008) Valerie G Brunton et al.   CURRENT OPINION IN PHARMACOLOGY

Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK

(2008) Sara M. Weis et al.   JOURNAL OF CELL BIOLOGY

Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation

(2008) Tuomas Tammela et al.   NATURE