Selective inhibition of brain endothelial Rho-kinase-2 provides optimal protection of an in vitro blood-brain barrier from tissue-type plasminogen activator and plasmin

Heterogeneous Impact of ROCK2 on Carotid and Cerebrovascular FunctionNovelty and Significance

(2016) T. Michael De Silva et al.   HYPERTENSION

A Review of the Mechanisms of Blood-Brain Barrier Permeability by Tissue-Type Plasminogen Activator Treatment for Cerebral Ischemia

(2016) Yasuhiro Suzuki et al.   Frontiers in Cellular Neuroscience

Recombinant Tissue Plasminogen Activator Induces Neurological Side Effects Independent on Thrombolysis in Mechanical Animal Models of Focal Cerebral Infarction: A Systematic Review and Meta-Analysis

(2016) Mei-Xue Dong et al.   PLoS One

ROCK1 and 2 differentially regulate actomyosin organization to drive cell and synaptic polarity

(2015) Karen A. Newell-Litwa et al.   JOURNAL OF CELL BIOLOGY

Pharmacological therapy of acute ischaemic stroke: Achievements and problems

(2015) Antonio Moretti et al.   PHARMACOLOGY & THERAPEUTICS

ROCK2 primes the endothelium for vascular hyperpermeability responses by raising baseline junctional tension

(2015) Cora M.L. Beckers et al.   VASCULAR PHARMACOLOGY

The Function of Rho-Associated Kinases ROCK1 and ROCK2 in the Pathogenesis of Cardiovascular Disease

(2015) Svenja Hartmann et al.   Frontiers in Pharmacology

Plasmin-Dependent Modulation of the Blood–Brain Barrier: A Major Consideration during tPA-Induced Thrombolysis?

(2014) Be'eri Niego et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Inhibition of Rho-kinase protects cerebral barrier from ischaemia-evoked injury through modulations of endothelial cell oxidative stress and tight junctions

(2014) Claire L. Gibson et al.   JOURNAL OF NEUROCHEMISTRY

Selective oral ROCK2 inhibitor down-regulates IL-21 and IL-17 secretion in human T cells via STAT3-dependent mechanism

(2014) Alexandra Zanin-Zhorov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Symptomatic Intracerebral Hemorrhage in Acute Ischemic Stroke After Thrombolysis With Intravenous Recombinant Tissue Plasminogen Activator

(2014) Shadi Yaghi et al.   JAMA Neurology

Complications Associated with Recombinant Tissue Plasminogen Activator Therapy for Acute Ischaemic Stroke

(2013) Joyce S. Balami et al.   CNS & Neurological Disorders-Drug Targets

Distinct roles for ROCK1 and ROCK2 in the regulation of cell detachment

(2013) Jianjian Shi et al.   Cell Death & Disease

Selective ROCK2 inhibition in focal cerebral ischemia

(2013) Jeong Hyun Lee et al.   Annals of Clinical and Translational Neurology

t-PA-specific modulation of a human blood-brain barrier model involves plasmin-mediated activation of the Rho kinase pathway in astrocytes

(2012) B. Niego et al.   BLOOD

Distinct Distribution and Localization of Rho-kinase in Mouse Epithelial, Muscle and Neural Tissues

(2012) Michiro Iizuka et al.   CELL STRUCTURE AND FUNCTION

Rock1 & 2 Perform Overlapping and Unique Roles in Angiogenesis and Angiosarcoma Tumor Progression

(2012) J. Montalvo et al.   CURRENT MOLECULAR MEDICINE

Striking crosstalk of ROCK signaling with endothelial function

(2012) Kensuke Noma et al.   Journal of Cardiology

A Rho kinase (ROCK) inhibitor, fasudil, prevents matrix metalloproteinase-9-related hemorrhagic transformation in mice treated with tissue plasminogen activator

(2012) M. Ishiguro et al.   NEUROSCIENCE

The Rho-Kinase (ROCK) Inhibitor Y-27632 Protects Against Excitotoxicity-Induced Neuronal Death In Vivo and In Vitro

(2012) Byeong Tak Jeon et al.   NEUROTOXICITY RESEARCH

Role of Histone Acetylation in the Stimulatory Effect of Valproic Acid on Vascular Endothelial Tissue-Type Plasminogen Activator Expression

(2012) Pia Larsson et al.   PLoS One

Truncation of monocyte chemoattractant protein 1 by plasmin promotes blood-brain barrier disruption

(2011) Y. Yao et al.   JOURNAL OF CELL SCIENCE

Rho-Kinase in Development and Heart Failure: Insights From Genetic Models

(2011) Jianjian Shi et al.   PEDIATRIC CARDIOLOGY

RhoA/ROCK signaling is essential for multiple aspects of VEGF-mediated angiogenesis

(2010) Brad A. Bryan et al.   FASEB JOURNAL

Rho Kinase-2 Activation in Human Endothelial Cells Drives Lysophosphatidic Acid-mediated Expression of Cell Adhesion Molecules via NF-κB p65

(2010) Hideaki Shimada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small GTPase RhoA and Its Effector Rho Kinase Mediate Oxygen Glucose Deprivation-Evoked In Vitro Cerebral Barrier Dysfunction

(2010) Claire Allen et al.   STROKE

Amelioration of endothelial damage/dysfunction is a possible mechanism for the neuroprotective effects of Rho-kinase inhibitors against ischemic brain damage

(2009) Shin-ichi Satoh et al.   BRAIN RESEARCH BULLETIN

ROCK Isoform Regulation of Myosin Phosphatase and Contractility in Vascular Smooth Muscle Cells

(2009) Yuepeng Wang et al.   CIRCULATION RESEARCH

Activation of Rho Kinase Isoforms in Lung Endothelial Cells during Inflammation

(2009) P. Y. Mong et al.   JOURNAL OF IMMUNOLOGY

Comparative gene expression profiling in three primary human cell lines after treatment with a novel inhibitor of Rho kinase or atorvastatin

(2008) Marjan Boerma et al.   BLOOD COAGULATION & FIBRINOLYSIS

Demonstration of elevation and localization of Rho-kinase activity in the brain of a rat model of cerebral infarction

(2008) Kazuo Yano et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke

(2008) Enming J Su et al.   NATURE MEDICINE