Model-Based Methods in the Biopharmaceutical Process Lifecycle

Quantitative determination of nine water-soluble vitamins in the complex matrix of corn steep liquor for raw material quality assessment

(2017) Alexandra Hofer et al.   JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY

Workflow to set up substantial target-oriented mechanistic process models in bioprocess engineering

(2017) Paul Kroll et al.   PROCESS BIOCHEMISTRY

Model-based real-time optimisation of a fed-batch cyanobacterial hydrogen production process using economic model predictive control strategy

(2016) Ehecatl Antonio del Rio-Chanona et al.   CHEMICAL ENGINEERING SCIENCE

Combining Mechanistic Modeling and Raman Spectroscopy for Real-Time Monitoring of Fed-Batch Penicillin Production

(2016) Aydin Golabgir et al.   CHEMIE INGENIEUR TECHNIK

State estimation incorporating infrequent, delayed and integral measurements

(2015) Yafeng Guo et al.   AUTOMATICA

Review and classification of recent observers applied in chemical process systems

(2015) Jarinah Mohd Ali et al.   COMPUTERS & CHEMICAL ENGINEERING

Nonlinear ill-posed problem analysis in model-based parameter estimation and experimental design

(2015) Diana C. López C. et al.   COMPUTERS & CHEMICAL ENGINEERING

Modeling of an aerobic bioprocess based on gas exchange and dynamics: a novel approach

(2014) Cyril Lemaire et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Mini-review: soft sensors as means for PAT in the manufacture of bio-therapeutics

(2014) Carl-Fredrik Mandenius et al.   JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY

Partial least squares discriminant analysis: taking the magic away

(2014) Richard G. Brereton et al.   JOURNAL OF CHEMOMETRICS

Glucose concentration control of a fed-batch mammalian cell bioprocess using a nonlinear model predictive controller

(2014) Stephen Craven et al.   JOURNAL OF PROCESS CONTROL

Kinetic models in industrial biotechnology – Improving cell factory performance

(2014) Joachim Almquist et al.   METABOLIC ENGINEERING

Design, Execution, and Analysis of Time-Varying Experiments for Model Discrimination and Parameter Estimation in Microreactors

(2014) Spencer D. Schaber et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Simultaneous solution approach to model-based experimental design

(2013) M. D. Hoang et al.   AICHE JOURNAL

Automatic identification of structured process models based on biological phenomena detected in (fed-)batch experiments

(2013) Sebastian Herold et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Model-based identifiable parameter determination applied to a simultaneous saccharification and fermentation process model for bio-ethanol production

(2013) Diana C. López C. et al.   BIOTECHNOLOGY PROGRESS

Multiobjective Framework for Model-based Design of Experiments to Improve Parameter Precision and Minimize Parameter Correlation

(2013) Vaibhav Maheshwari et al.   INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

Classification and analysis of corn steep liquor by UPLC/Q-TOF MS and HPLC

(2013) Xue Xiao et al.   TALANTA

Experimental evaluation of an approach to online redesign of experiments for parameter determination

(2012) Tilman Barz et al.   AICHE JOURNAL

Macroscopic modelling of overflow metabolism and model based optimization of hybridoma cell fed-batch cultures

(2012) Zakaria Amribt et al.   BIOCHEMICAL ENGINEERING JOURNAL

Real-time estimation of biomass and specific growth rate in physiologically variable recombinant fed-batch processes

(2012) Patrick Wechselberger et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Process model comparison and transferability across bioreactor scales and modes of operation for a mammalian cell bioprocess

(2012) Stephen Craven et al.   BIOTECHNOLOGY PROGRESS

Model-based analysis on the extractability of information from data in dynamic fed-batch experiments

(2012) Patrick Wechselberger et al.   BIOTECHNOLOGY PROGRESS

Optimal experiment design for dynamic bioprocesses: A multi-objective approach

(2012) D. Telen et al.   CHEMICAL ENGINEERING SCIENCE

Determination of Main Categories of Components in Corn Steep Liquor by Near-Infrared Spectroscopy and Partial Least-Squares Regression

(2012) Xue Xiao et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Support vector machine regression (SVR/LS-SVM)—an alternative to neural networks (ANN) for analytical chemistry? Comparison of nonlinear methods on near infrared (NIR) spectroscopy data

(2011) Roman M. Balabin et al.   ANALYST

Process analytical technology (PAT) for biopharmaceuticals

(2011) Jarka Glassey et al.   Biotechnology Journal

Simplified off-gas analyses in animal cell cultures for process monitoring and control purposes

(2011) Mathias Aehle et al.   BIOTECHNOLOGY LETTERS

Predicting mab product yields from cultivation media components, using near-infrared and 2D-fluorescence spectroscopies

(2011) Gledson E. Jose et al.   BIOTECHNOLOGY PROGRESS

Robust multi-objective optimal control of uncertain (bio)chemical processes

(2011) Filip Logist et al.   CHEMICAL ENGINEERING SCIENCE

Model-Based Design of Experiments in the Presence of Continuous Measurement Systems

(2011) Federico Galvanin et al.   INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

Comprehensive Quality Evaluation of Corn Steep Liquor in 2-Keto-l-gulonic Acid Fermentation

(2011) Yun Gao et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Observability analysis for model-based fault detection and sensor selection in induction motors

(2011) Mohsen Nakhaeinejad et al.   MEASUREMENT SCIENCE and TECHNOLOGY

Model selection, identification and validation in anaerobic digestion: A review

(2011) Andres Donoso-Bravo et al.   WATER RESEARCH

On-line infrared spectroscopy for bioprocess monitoring

(2010) Daniel Landgrebe et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Real time monitoring of multiple parameters in mammalian cell culture bioreactors using an in-line Raman spectroscopy probe

(2010) Nicholas R. Abu-Absi et al.   BIOTECHNOLOGY AND BIOENGINEERING

Rapid characterization and quality control of complex cell culture media solutions using raman spectroscopy and chemometrics

(2010) Boyan Li et al.   BIOTECHNOLOGY AND BIOENGINEERING

PAT method to gather bioprocess parameters in real-time using simple input variables and first principle relationships

(2010) Patrick Wechselberger et al.   CHEMICAL ENGINEERING SCIENCE

Data analysis in flow cytometry: The future just started

(2010) Enrico Lugli et al.   CYTOMETRY PART A

Increasing batch-to-batch reproducibility of CHO cultures by robust open-loop control

(2010) M. Aehle et al.   CYTOTECHNOLOGY

Differential Evolution: A Survey of the State-of-the-Art

(2010) Swagatam Das et al.   IEEE TRANSACTIONS ON EVOLUTIONARY COMPUTATION

Handling Uncertainty in Model-Based Optimal Experimental Design

(2010) Tilman Barz et al.   INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

Calorimetric control for high cell density cultivation of a recombinant Escherichia coli strain

(2010) Richard Biener et al.   JOURNAL OF BIOTECHNOLOGY

Incorporating delayed and infrequent measurements in Extended Kalman Filter based nonlinear state estimation

(2010) Ajit Gopalakrishnan et al.   JOURNAL OF PROCESS CONTROL

Structural and practical identifiability analysis of partially observed dynamical models by exploiting the profile likelihood

(2009) A. Raue et al.   BIOINFORMATICS

Quality by design case study: An integrated multivariate approach to drug product and process development

(2009) Jun Huang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Quality by design for biopharmaceuticals

(2009) Anurag S Rathore et al.   NATURE BIOTECHNOLOGY

Review of the most common pre-processing techniques for near-infrared spectra

(2009) Åsmund Rinnan et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Novel anticorrelation criteria for model-based experiment design: Theory and formulations

(2008) Gaia Franceschini et al.   AICHE JOURNAL

Ensemble preprocessing of near-infrared (NIR) spectra for multivariate calibration

(2008) Lu Xu et al.   ANALYTICA CHIMICA ACTA

Orthogonal Projections to Latent Structures Discriminant Analysis Modeling on in Situ FT-IR Spectral Imaging of Liver Tissue for Identifying Sources of Variability

(2008) Hans Stenlund et al.   ANALYTICAL CHEMISTRY

Analysis of theEscherichia coliresponse to glycerol pulse in continuous, high-cell density culture using a multivariate approach

(2008) Daniel V. Guebel et al.   BIOTECHNOLOGY AND BIOENGINEERING

Bioprocess optimization using design-of-experiments methodology

(2008) Carl-Fredrik Mandenius et al.   BIOTECHNOLOGY PROGRESS

Sequential experimental design for model discrimination

(2008) Marcio Schwaab et al.   CHEMICAL ENGINEERING SCIENCE

Parameter estimation and optimal experimental design

(2008) Julio R. Banga et al.   Essays in Biochemistry

Mining bioprocess data: opportunities and challenges

(2008) Salim Charaniya et al.   TRENDS IN BIOTECHNOLOGY

Model-based design of experiments for parameter precision: State of the art

(2007) Gaia Franceschini et al.   CHEMICAL ENGINEERING SCIENCE