P-glycoprotein (ABCB1) and Oxidative Stress: Focus on Alzheimer’s Disease

Protective effect of 3H-1, 2-dithiole-3-thione on cellular model of Alzheimer's disease involves Nrf2/ARE signaling pathway

(2017) Lan Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Blood-Brain Barrier Dysfunction and the Pathogenesis of Alzheimer’s Disease

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Apical-to-Basolateral Transport of Amyloid-β Peptides through Blood-Brain Barrier Cells is Mediated by the Receptor for Advanced Glycation End-Products and is Restricted by P-Glycoprotein

(2017) Pietra Candela et al.   JOURNAL OF ALZHEIMERS DISEASE

Early effects of Aβ 1-42 oligomers injection in mice: Involvement of PI3K/Akt/GSK3 and MAPK/ERK1/2 pathways

(2016) Fabiana Morroni et al.   BEHAVIOURAL BRAIN RESEARCH

Role of P-glycoprotein in mediating rivastigmine effect on amyloid-β brain load and related pathology in Alzheimer's disease mouse model

(2016) Loqman A. Mohamed et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Sulforaphane activates the cerebral vascular Nrf2–ARE pathway and suppresses inflammation to attenuate cerebral vasospasm in rat with subarachnoid hemorrhage

(2016) Xudong Zhao et al.   BRAIN RESEARCH

Comparison of Extracellular and Intracellular Blood Compartments Highlights Redox Alterations in Alzheimer's and Mild Cognitive Impairment Patients

(2016) Noemí Arce-Varas et al.   Current Alzheimer Research

Molecular Basis of Familial and Sporadic Alzheimer's Disease

(2016) Jolanta Dorszewska et al.   Current Alzheimer Research

Discovery of a marine-derived bis-indole alkaloid fascaplysin, as a new class of potent P-glycoprotein inducer and establishment of its structure–activity relationship

(2016) Sudhakar Manda et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A 40 Reduces P-Glycoprotein at the Blood-Brain Barrier through the Ubiquitin-Proteasome Pathway

(2016) A. M. S. Hartz et al.   JOURNAL OF NEUROSCIENCE

Oleocanthal Enhances Amyloid-β Clearance from the Brains of TgSwDI Mice and in Vitro across a Human Blood-Brain Barrier Model

(2015) Hisham Qosa et al.   ACS Chemical Neuroscience

Targeting transporters: Promoting blood–brain barrier repair in response to oxidative stress injury

(2015) Patrick T. Ronaldson et al.   BRAIN RESEARCH

Possible role of P-glycoprotein in the neuroprotective mechanism of berberine in intracerebroventricular streptozotocin-induced cognitive dysfunction

(2015) Anil Kumar et al.   PSYCHOPHARMACOLOGY

Neuroprotection by 6-(methylsulfinyl)hexyl isothiocyanate in a 6-hydroxydopamine mouse model of Parkinson׳s disease

(2014) Fabiana Morroni et al.   BRAIN RESEARCH

ABCB1 C3435T Polymorphism Influences the Risk for Alzheimer’s Disease

(2014) Ágnes Fehér et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Nrf2 Upregulates ATP Binding Cassette Transporter Expression and Activity at the Blood-Brain and Blood-Spinal Cord Barriers

(2014) X. Wang et al.   JOURNAL OF NEUROSCIENCE

1 ,25-Dihydroxyvitamin D3 Reduces Cerebral Amyloid-  Accumulation and Improves Cognition in Mouse Models of Alzheimer's Disease

(2014) M. R. Durk et al.   JOURNAL OF NEUROSCIENCE

Vascular and extravascular distribution of the ATP-binding cassette transporters ABCB1 and ABCC1 in aged human brain and pituitary

(2014) Hans-Gert Bernstein et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Implication of P-Glycoprotein in Formation of Depression-Prone Personality: Association Study between the C3435TMDR1Gene Polymorphism and Interpersonal Sensitivity

(2014) Masanori Enokido et al.   NEUROPSYCHOBIOLOGY

Novel and functional ABCB1 gene variant in sporadic Parkinson’s disease

(2014) Yuequn Li et al.   NEUROSCIENCE LETTERS

Downregulation of Blood-Brain Barrier Phenotype by Proinflammatory Cytokines Involves NADPH Oxidase-Dependent ROS Generation: Consequences for Interendothelial Adherens and Tight Junctions

(2014) Keith D. Rochfort et al.   PLoS One

Aβ1–42 reduces P-glycoprotein in the blood–brain barrier through RAGE–NF-κB signaling

(2014) R Park et al.   Cell Death & Disease

Olive-Oil-Derived Oleocanthal Enhances β-Amyloid Clearance as a Potential Neuroprotective Mechanism against Alzheimer’s Disease: In Vitro and in Vivo Studies

(2013) Alaa H. Abuznait et al.   ACS Chemical Neuroscience

St. John's Wort Reduces Beta-Amyloid Accumulation in a Double Transgenic Alzheimer's Disease Mouse Model-Role of P-Glycoprotein

(2013) Anja Brenn et al.   BRAIN PATHOLOGY

Why Clinical Modulation of Efflux Transport at the Human Blood–Brain Barrier Is Unlikely: The ITC Evidence-Based Position

(2013) J C Kalvass et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Signaling Pathways that Regulate Basal ABC Transporter Activity at the Blood- Brain Barrier

(2013) David Miller et al.   CURRENT PHARMACEUTICAL DESIGN

Common Genetic Polymorphisms in the ABCB1 Gene Are Associated with Risk of Major Depressive Disorder in Male Portuguese Individuals

(2013) Marlene Santos et al.   Genetic Testing and Molecular Biomarkers

Early Inhibition of MMP Activity in Ischemic Rat Brain Promotes Expression of Tight Junction Proteins and Angiogenesis During Recovery

(2013) Yi Yang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Oxidative Stress and the Pathogenesis of Alzheimer's Disease

(2013) Yan Zhao et al.   Oxidative Medicine and Cellular Longevity

The role of ABCB1 and ABCA1 in beta-amyloid clearance at the neurovascular unit in Alzheimer's disease

(2013) Ayman ElAli et al.   Frontiers in Physiology

The Role of the ATP-Binding Cassette Transporter P-Glycoprotein in the Transport of β-Amyloid Across the Blood-Brain Barrier

(2012) Silke Vogelgesang et al.   CURRENT PHARMACEUTICAL DESIGN

Blood-Brain Barrier P-Glycoprotein Function in Neurodegenerative Disease

(2012) A.L. Bartels   CURRENT PHARMACEUTICAL DESIGN

Blood-Brain Barrier Integrity and Glial Support: Mechanisms that can be Targeted for Novel Therapeutic Approaches in Stroke

(2012) Patrick T. Ronaldson et al.   CURRENT PHARMACEUTICAL DESIGN

1α,25-Dihydroxyvitamin D3-liganded vitamin D receptor increases expression and transport activity of P-glycoprotein in isolated rat brain capillaries and human and rat brain microvessel endothelial cells

(2012) Matthew R. Durk et al.   JOURNAL OF NEUROCHEMISTRY

Lipopolysaccharide impairs amyloid beta efflux from brain: altered vascular sequestration, cerebrospinal fluid reabsorption, peripheral clearance and transporter function at the blood–brain barrier

(2012) Michelle A Erickson et al.   Journal of Neuroinflammation

Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection

(2012) Meijuan Zhang et al.   PROGRESS IN NEUROBIOLOGY

Blood–brain barrier P-glycoprotein function in healthy subjects and Alzheimer's disease patients: effect of polymorphisms in the ABCB1 gene

(2012) Daniëlle ME van Assema et al.   EJNMMI Research

ABC Transporters and the Alzheimer’s Disease Enigma

(2012) Andrea Wolf et al.   Frontiers in Psychiatry

Tempol modulates changes in xenobiotic permeability and occludin oligomeric assemblies at the blood-brain barrier during inflammatory pain

(2011) Jeffrey J. Lochhead et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Amyloid Beta Induces Oxidative Stress-Mediated Blood–Brain Barrier Changes in Capillary Amyloid Angiopathy

(2011) Anna Carrano et al.   ANTIOXIDANTS & REDOX SIGNALING

Blood–brain barrier P-glycoprotein function in Alzheimer's disease

(2011) Daniëlle M. E. van Assema et al.   BRAIN

Beta amyloid effects on expression of multidrug efflux transporters in brain endothelial cells

(2011) Katarzyna D. Kania et al.   BRAIN RESEARCH

Microglia Phenotype Diversity

(2011) M. Olah et al.   CNS & Neurological Disorders-Drug Targets

TLR2 Is a Primary Receptor for Alzheimer's Amyloid   Peptide To Trigger Neuroinflammatory Activation

(2011) S. Liu et al.   JOURNAL OF IMMUNOLOGY

1 ,25-Dihydroxyvitamin D3 Up-Regulates P-Glycoprotein via the Vitamin D Receptor and Not Farnesoid X Receptor in Both fxr(-/-) and fxr(+/+) Mice and Increased Renal and Brain Efflux of Digoxin in Mice In Vivo

(2011) E. C. Y. Chow et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The projected effect of risk factor reduction on Alzheimer's disease prevalence

(2011) Deborah E Barnes et al.   LANCET NEUROLOGY

Amyloid-β Contributes to Blood–Brain Barrier Leakage in Transgenic Human Amyloid Precursor Protein Mice and in Humans With Cerebral Amyloid Angiopathy

(2011) Anika M.S. Hartz et al.   STROKE

ABC efflux transporters in brain vasculature of Alzheimer's subjects

(2010) Hasini C. Wijesuriya et al.   BRAIN RESEARCH

Is P-glycoprotein Involved in Amyloid-β Elimination Across the Blood–Brain Barrier in Alzheimer’s Disease?

(2010) S Ohtsuki et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Oxidative Stress Increases Blood–Brain Barrier Permeability and Induces Alterations in Occludin during Hypoxia–Reoxygenation

(2010) Jeffrey J Lochhead et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Low-density lipoprotein receptor-related protein-1: a serial clearance homeostatic mechanism controlling Alzheimer’s amyloid β-peptide elimination from the brain

(2010) Berislav V. Zlokovic et al.   JOURNAL OF NEUROCHEMISTRY

Amyloid-Independent Mechanisms in Alzheimer's Disease Pathogenesis

(2010) S. W. Pimplikar et al.   JOURNAL OF NEUROSCIENCE

Restoring Blood-Brain Barrier P-Glycoprotein Reduces Brain Amyloid-  in a Mouse Model of Alzheimer's Disease

(2010) A. M. S. Hartz et al.   MOLECULAR PHARMACOLOGY

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

Regulation of P-glycoprotein and other ABC drug transporters at the blood–brain barrier

(2010) David S. Miller   TRENDS IN PHARMACOLOGICAL SCIENCES

Variations in the neuropathology of familial Alzheimer’s disease

(2009) Claire Shepherd et al.   ACTA NEUROPATHOLOGICA

Clearance of Amyloid-β Peptide Across the Blood-Brain Barrier: Implication for Therapies in Alzheimers Disease

(2009) R. Deane et al.   CNS & Neurological Disorders-Drug Targets

Depletion of Vitamin E Increases Amyloid β Accumulation by Decreasing Its Clearances from Brain and Blood in a Mouse Model of Alzheimer Disease

(2009) Yoichiro Nishida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidative stress up-regulates presenilin 1 in lipid rafts in neuronal cells

(2009) Akiko Oda et al.   JOURNAL OF NEUROSCIENCE RESEARCH

ABC Transporter (P-gp/ABCB1, MRP1/ABCC1, BCRP/ABCG2) Expression in the Developing Human CNS

(2009) M. Daood et al.   NEUROPEDIATRICS

P-Glycoprotein Acts as an Immunomodulator during Neuroinflammation

(2009) Gijs Kooij et al.   PLoS One

Lysosomal Storage Diseases and the Blood-Brain Barrier

(2008) David Begley et al.   CURRENT PHARMACEUTICAL DESIGN

Diesel exhaust particles induce oxidative stress, proinflammatory signaling, and P-glycoprotein up-regulation at the blood-brain barrier

(2008) Anika M. S. Hartz et al.   FASEB JOURNAL

Role of the p38 Mitogen-Activated Protein Kinase/Cytosolic Phospholipase A2 Signaling Pathway in Blood—Brain Barrier Disruption after Focal Cerebral Ischemia and Reperfusion

(2008) Chikako Nito et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Differential expression of the multidrug resistance-related proteins ABCb1 and ABCc1 between blood-brain interfaces

(2008) Silvia Gazzin et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Decreased blood–brain barrier P-glycoprotein function in the progression of Parkinson’s disease, PSP and MSA

(2008) A. L. Bartels et al.   JOURNAL OF NEURAL TRANSMISSION

HIV-1 viral envelope glycoprotein gp120 produces oxidative stress and regulates the functional expression of multidrug resistance protein-1 (Mrp1) in glial cells

(2008) Patrick T. Ronaldson et al.   JOURNAL OF NEUROCHEMISTRY