Journal
CURRENT PHARMACEUTICAL DESIGN
Volume 17, Issue 26, Pages 2778-2786Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138161211797440168
Keywords
beta-amyloid; P-glycoprotein; Alzheimer's disease; neurodegeneration; blood-brain barrier; Creutzfeldt-Jakob disease; aging
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The blood-brain barrier (BBB) protects the brain against endogenous and exogenous compounds and plays an important part in the maintenance of the microenvironment of the brain. In particular, the importance of brain-to-blood transport of brain-derived metabolites across the BBB has gained increasing attention as a potential mechanism in the pathogenesis of neurodegenerative disorders such as Alzheimer's disease, which is characterized by the aberrant polymerization and accumulation of specific misfolded proteins, particularly beta-amyloid (A beta). There is growing evidence that the ABC transport protein P-glycoprotein (P-gp), a major component of the BBB, mediates the efflux of A beta from the brain. In this review, we discuss the possible role of P-gp in Alzheimer's disease and other neurodegenerative disorders, and consider how a fuller understanding of this function might promote the development of more effective treatment strategies.
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