Impact on Autophagy and Ultraviolet B Induced Responses of Treatment with the MTOR Inhibitors Rapamycin, Everolimus, Torin 1, and pp242 in Human Keratinocytes

The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14

(2016) Ji-Man Park et al.   Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

The protective role of autophagy in experimental osteoarthritis, and the therapeutic effects of Torin 1 on osteoarthritis by activating autophagy

(2016) Ni-Tao Cheng et al.   BMC MUSCULOSKELETAL DISORDERS

Photopreventive Effect and Mechanism of AZD4547 and Curcumin C3 Complex on UVB-Induced Epidermal Hyperplasia

(2016) Alok R. Khandelwal et al.   Cancer Prevention Research

Inhibition of mTOR by apigenin in UVB-irradiated keratinocytes: A new implication of skin cancer prevention

(2016) Bryan B. Bridgeman et al.   CELLULAR SIGNALLING

Constitutive Autophagy and Nucleophagy during Epidermal Differentiation

(2016) Olufolake Akinduro et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

An Evaluation of Root Phytochemicals Derived fromAlthea officinalis(Marshmallow) andAstragalus membranaceusas Potential Natural Components of UV Protecting Dermatological Formulations

(2016) Alison Curnow et al.   Oxidative Medicine and Cellular Longevity

(Z)-5-(2,4-Dihydroxybenzylidene)thiazolidine-2,4-dione Prevents UVB-Induced Melanogenesis and Wrinkle Formation through Suppressing Oxidative Stress in HRM-2 Hairless Mice

(2016) Bonggi Lee et al.   Oxidative Medicine and Cellular Longevity

mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation

(2016) Xiaolei Ding et al.   Nature Communications

Dual inhibition of ATR and ATM potentiates the activity of trabectedin and lurbinectedin by perturbing the DNA damage response and homologous recombination repair

(2016) Michelle Lima et al.   Oncotarget

Trehalose, sucrose and raffinose are novel activators of autophagy in human keratinocytes through an mTOR-independent pathway

(2016) Xu Chen et al.   Scientific Reports

Thymosin alpha 1 suppresses proliferation and induces apoptosis in breast cancer cells through PTEN-mediated inhibition of PI3K/Akt/mTOR signaling pathway

(2015) Yan Guo et al.   APOPTOSIS

Autophagy positively regulates DNA damage recognition by nucleotide excision repair

(2015) Lei Qiang et al.   Autophagy

Farnesol activates the intrinsic pathway of apoptosis and the ATF4-ATF3-CHOP cascade of ER stress in human T lymphoblastic leukemia Molt4 cells

(2015) Joung Hyuck Joo et al.   BIOCHEMICAL PHARMACOLOGY

The PI3K/mTOR inhibitor PF-04691502 induces apoptosis and inhibits microenvironmental signaling in CLL and the E -TCL1 mouse model

(2015) M. D. Blunt et al.   BLOOD

The dual PI3K/mTOR inhibitor NVP-BEZ235 inhibits proliferation and induces apoptosis of burkitt lymphoma cells

(2015) Chuntuan Li et al.   Cancer Cell International

P38 and JNK signal pathways are involved in the regulation of phlorizin against UVB-induced skin damage

(2015) Yimiao Zhai et al.   EXPERIMENTAL DERMATOLOGY

UV Light Potentiates STING (Stimulator of Interferon Genes)-dependent Innate Immune Signaling through Deregulation of ULK1 (Unc51-like Kinase 1)

(2015) Michael G. Kemp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bergapten drives autophagy through the up-regulation of PTEN expression in breast cancer cells

(2015) Francesca De Amicis et al.   Molecular Cancer

Dandelion Extracts Protect Human Skin Fibroblasts from UVB Damage and Cellular Senescence

(2015) Yafan Yang et al.   Oxidative Medicine and Cellular Longevity

mTOR kinase inhibitor pp242 causes mitophagy terminated by apoptotic cell death in E1A-Ras transformed cells

(2015) Serguei A. Gordeev et al.   Oncotarget

Dual mTORC1/C2 inhibitors suppress cellular geroconversion (a senescence program)

(2015) Olga V. Leontieva et al.   Oncotarget

GVHD prophylaxis with sirolimus-tacrolimus may overcome the deleterious effect on survival of HLA mismatch after reduced-intensity conditioning allo-SCT

(2014) R Parody et al.   BONE MARROW TRANSPLANTATION

C/EBPα regulates CRL4Cdt2-mediated degradation of p21 in response to UVB-induced DNA damage to control the G1/S checkpoint

(2014) Jonathan R Hall et al.   CELL CYCLE

Stress-induced ceramide generation and apoptosis via the phosphorylation and activation of nSMase1 by JNK signaling

(2014) T Yabu et al.   CELL DEATH AND DIFFERENTIATION

Making new contacts: the mTOR network in metabolism and signalling crosstalk

(2014) Mitsugu Shimobayashi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Synergism between mTOR pathway and ultraviolet radiation in the pathogenesis of squamous cell carcinoma and its implication for solid-organ transplant recipients

(2014) Yevgeniy Balagula et al.   PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE

Tacrolimus (FK506) Suppresses TREM-1 Expression at an Early but Not at a Late Stage in a Murine Model of Fungal Keratitis

(2014) Weilan Huang et al.   PLoS One

MTOR inhibition attenuates DNA damage and apoptosis through autophagy-mediated suppression of CREB1

(2013) Ying Wang et al.   Autophagy

Photoprotective effect of libanoridin isolated fromCorydalis heterocarpaon UVB stressed human keratinocyte cells

(2013) Byul-Nim Ahn et al.   EXPERIMENTAL DERMATOLOGY

UVB-induced anti-survival and pro-apoptotic effects on HaCaT human keratinocytes via caspase- and PKC-dependent downregulation of PKB, HIAP-1, Mcl-1, XIAP and ER stress

(2013) YU-KYOUNG PARK et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Unfolded Protein Response Signaling and Metabolic Diseases

(2013) Jaemin Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epidermal keratinocytes form a functional skin barrier in the absence of Atg7 dependent autophagy

(2013) Heidemarie Rossiter et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Everolimus-induced human keratinocytes toxicity is mediated by STAT3 inhibition

(2013) Kazuhiro Yamamoto et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

DNA-dependent protein kinase catalytic subunit (DNA-PKcs)-SIN1 association mediates ultraviolet B (UVB)-induced Akt Ser-473 phosphorylation and skin cell survival

(2013) Ying Tu et al.   Molecular Cancer

mTOR is a key modulator of ageing and age-related disease

(2013) Simon C. Johnson et al.   NATURE

Plasma Lipoproteins as Mediators of the Oxidative Stress Induced by UV Light in Human Skin: A Review of Biochemical and Biophysical Studies on Mechanisms of Apolipoprotein Alteration, Lipid Peroxidation, and Associated Skin Cell Responses

(2013) Paulo Filipe et al.   Oxidative Medicine and Cellular Longevity

The epithelium specific cell cycle regulator 14-3-3sigma is required for preventing entry into mitosis following ultraviolet B

(2013) Sandra Vogel et al.   PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE

A Comparative, Randomized Trial of Concentration-Controlled Sirolimus Combined With Reduced-Dose Tacrolimus or Standard-Dose Tacrolimus in Renal Allograft Recipients

(2013) W.O. Bechstein et al.   TRANSPLANTATION PROCEEDINGS

Mesoporous carbon@silicon-silica nanotheranostics for synchronous delivery of insoluble drugs and luminescence imaging

(2012) Qianjun He et al.   BIOMATERIALS

Targeting of mTORC1/2 by the mTOR kinase inhibitor PP242 induces apoptosis in AML cells under conditions mimicking the bone marrow microenvironment

(2012) Z. Zeng et al.   BLOOD

Inhibition of mTOR Suppresses UVB-Induced Keratinocyte Proliferation and Survival

(2012) T. D. Carr et al.   Cancer Prevention Research

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

All-trans-retinoic acid ameliorates experimental allergic encephalomyelitis by affecting dendritic cell and monocyte development

(2012) Xiao-Xia Zhan et al.   IMMUNOLOGY

Induction of Autophagy by Palmitic Acid via Protein Kinase C-mediated Signaling Pathway Independent of mTOR (Mammalian Target of Rapamycin)

(2012) Shi Hao Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of AMPK in UVB-induced DNA damage repair and growth control

(2012) C L Wu et al.   ONCOGENE

Differential Activation of Signaling Pathways by UVA and UVB Radiation in Normal Human Epidermal Keratinocytes†

(2012) Deeba N. Syed et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Brain and muscle Arnt-like protein-1 (BMAL1) controls circadian cell proliferation and susceptibility to UVB-induced DNA damage in the epidermis

(2012) M. Geyfman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling

(2012) Christian Appenzeller-Herzog et al.   TRENDS IN CELL BIOLOGY

mTOR protein localization is cell cycle-regulated

(2011) Margit Rosner et al.   CELL CYCLE

Complex Inhibitory Effects of Nitric Oxide on Autophagy

(2011) Sovan Sarkar et al.   MOLECULAR CELL

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

In vivo imaging of early stage apoptosis by measuring real-time caspase-3/7 activation

(2010) Matteo Scabini et al.   APOPTOSIS

ER signaling is activated to protect human HaCaT keratinocytes from ER stress induced by environmental doses of UVB

(2010) Kentaro Mera et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

Knockdown of Filaggrin Impairs Diffusion Barrier Function and Increases UV Sensitivity in a Human Skin Model

(2010) Michael Mildner et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

UVB-Induced p21 degradation promotes apoptosis of human keratinocytes

(2010) Xia Lei et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

An Emerging Role of mTOR in Lipid Biosynthesis

(2009) Mathieu Laplante et al.   CURRENT BIOLOGY

mTOR Ser-2481 Autophosphorylation Monitors mTORC-specific Catalytic Activity and Clarifies Rapamycin Mechanism of Action

(2009) Ghada A. Soliman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of Rictor Phosphorylation Sites Reveals Direct Regulation of mTOR Complex 2 by S6K1

(2009) C. C. Dibble et al.   MOLECULAR AND CELLULAR BIOLOGY

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

(2008) Juan M. García-Martínez et al.   BIOCHEMICAL JOURNAL

Candida albicansphospholipomannan triggers inflammatory responses of human keratinocytes through Toll-like receptor 2

(2008) Min Li et al.   EXPERIMENTAL DERMATOLOGY

Green tea extract reduces induction of p53 and apoptosis in UVB-irradiated human skin independent of transcriptional controls

(2008) Christian D. Mnich et al.   EXPERIMENTAL DERMATOLOGY

Use of sirolimus (rapamycin) to treat refractory Crohn's disease

(2008) D C O Massey et al.   GUT

Pimecrolimus Enhances TLR2/6-Induced Expression of Antimicrobial Peptides in Keratinocytes

(2008) Amanda S. Büchau et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Attenuation of UVB-Induced Sunburn Reaction and Oxidative DNA Damage with no Alterations in UVB-Induced Skin Carcinogenesis in Nrf2 Gene-Deficient Mice

(2008) Yasuhiro Kawachi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity

(2008) Andrew Xiao et al.   NATURE

Novel targets for Huntington's disease in an mTOR-independent autophagy pathway

(2008) Andrea Williams et al.   Nature Chemical Biology